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논문 상세정보

메틸사이클로핵산 (methylcyclohexane)의 흡입독성과 유해성 평가

A Study on the Hazardousness Evaluation and the Inhalation Toxicity of Methylcyclohexane

Abstract

From the harmfulness expectation test conducted through a toxicity anticipation program, methylcyclohexane turned out to be harmful and simulative, but no carcinogenicity was anticipated. In a four-hour acute inhalation toxicity test, the result showed that lethal concentration ($LC_{50}$) was 3,750 ppm (15,054 mg/L), which was identified as a harmful substance on the basis of the harmful substance classification standard $2 of the Industrial safety and health law. methylcyclohexane fell under the category $4(2,500 substance from the GHS standard acute toxicity harmfulness classification. Also, from subchronic inhalation toxicity test that included 6 hours a day, five days a week, and for 13 weeks, we could observe weight, activity, long term weight, blood and blood biochemical influence from the exposure of test substance. No-observed effect level (NOEL) was determined below $100{\sim}400ppm$ inboth male and female. This material falls under the Category 2 ($50{\sim}250ppm/6hours/90days$) in the GHS (Globally Harmonized System) standard trace long-term whole body toxicity repeated exposure, and can be classified as a harmful substance in accordance with the Industrial Safety and Health Law harmful substance standard $NOEL{\leq}0.5mg/L/6hr/90day$ (rat).

저자의 다른 논문

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이 논문을 인용한 문헌 (3)

  1. Kim, Hyeon-Yeong ; Lee, Sung-Bae ; Han, Jeong-Hee ; Kang, Min-Gu ; Yang, Jeong-Sun 2010. "Acute and Subchronic Inhalation Toxicity Evaluation of Methyl Formate in Rats" 환경독성보건학회지 = Environmental health and toxicology, 25(2): 131~143 
  2. Kim, Sung-Hwan ; Lim, Jeong-Hyeon ; Shin, In-Sik ; Moon, Changjong ; Kim, Sung-Ho ; Shin, Dong-Ho ; Kim, Jong-Choon 2011. "Single Oral Dose Toxicity Study of the Methylcyclohexane in Female Rats" 한국산업위생학회지 = Journal of Korean Society of Occupational and environmental hygiene, 21(1): 33~39 
  3. Kim, Hyeon-Yeong ; Kim, Tae-Gyun ; Kang, Min-Gu 2011. "Toxicity of Methylcyclohexane and the Effects on Nervous System" 한국산업위생학회지 = Journal of Korean Society of Occupational and environmental hygiene, 21(2): 82~89 

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