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Green Tea Catechin Causes an Weight Loss in Transgenic Mice Over-expressing Carboxyl Terminus of Amyloid Precusor Protein 원문보기

The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology, v.14 no.2, 2006년, pp.96 - 101  

Lim Hwa-J. (College of Pharmacy, Ewha Womans University) ,  Kim Yong-K. (Division of Laboratory Animal Resources, Korea Food and Drug Administration, National Institute of Toxicological Research) ,  Sheen Yhun-Y. (College of Pharmacy, Ewha Womans University)

Abstract ▼ AI-Helper 아이콘AI-Helper

Amyloid$\beta(A{\beta})$ has been reported have an effect on the induction of oxidative stress that involves the functional and structural abnormalities in Alzheimer's disease. As a role of a radical scavenger, a green tea treatment was found have some inhibitory effect on the neurodegene...

주제어

#Alzheimer transgenic   #Green tea catechin   #Weight loss  

AI 본문요약
AI-Helper 아이콘 AI-Helper

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문제 정의

  • In this study, transgenic mice, over-expressing NSE-controlled APP-C105 were successfully created and used to address the hypothesis that GTC might improve the body weight in this study. Induced level of Aβ-42 in transgenic brain was significantly lowed in body weight.

가설 설정

  • Why then should have a reduction in body weight by treatment of GTC? There are three possible explanations, i) Aβ-42- induced oxidative stress is reduced through the scavenging of hydroxyl radicals of GTC, and its reduction contributes the changes in the weight loss, ii) GTC can lower the cholesterol level by increasing the number of LDL-C receptors (LRP).
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참고문헌 (19)

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