Cardiovascular disease (CVD) risk factors may be acting several decades before CVD becomes manifest. Data from young subjects may be valuable in further elucidating at this issue. We evaluated the association between baPWV (brachial-ankle pulse wave velocity) and cardiovascular risk factors in appar...
Cardiovascular disease (CVD) risk factors may be acting several decades before CVD becomes manifest. Data from young subjects may be valuable in further elucidating at this issue. We evaluated the association between baPWV (brachial-ankle pulse wave velocity) and cardiovascular risk factors in apparently healthy young adults. A total of 46 male and 91 female adolescents aged $18{\sim}25 years$ were studied. baPWV increased in a dose-responsive manner as the number of metabolic syndrome components. In both gender groups, baPWV was positively correlated with age. In males, waist, circumference total cholesterol, and LDL-cholesterol were positively correlated with baPWV, and in females, blood pressure (BP) was positively correlated with baPWV. Age, gender, mean BP, and Homeostasis model assessment insulin resistance (HOMA-IR) were found to be independent factors associated with baPWV levels. In conclusion, mean BP, age, gender, and HOMA-IR were associated with baPWV in young adults. This result suggests that multiple cardiovascular risk factors may be associated with an increased risk of arterial stiffness in young adults.
Cardiovascular disease (CVD) risk factors may be acting several decades before CVD becomes manifest. Data from young subjects may be valuable in further elucidating at this issue. We evaluated the association between baPWV (brachial-ankle pulse wave velocity) and cardiovascular risk factors in apparently healthy young adults. A total of 46 male and 91 female adolescents aged $18{\sim}25 years$ were studied. baPWV increased in a dose-responsive manner as the number of metabolic syndrome components. In both gender groups, baPWV was positively correlated with age. In males, waist, circumference total cholesterol, and LDL-cholesterol were positively correlated with baPWV, and in females, blood pressure (BP) was positively correlated with baPWV. Age, gender, mean BP, and Homeostasis model assessment insulin resistance (HOMA-IR) were found to be independent factors associated with baPWV levels. In conclusion, mean BP, age, gender, and HOMA-IR were associated with baPWV in young adults. This result suggests that multiple cardiovascular risk factors may be associated with an increased risk of arterial stiffness in young adults.
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제안 방법
The distance between the right brachium and ankle was estimated based on body height. In addition, because there was a significant correlation between the right PWV and left PWV we used the resulting mean PWV for analysis. The coefficient of variation for interobserver reproducibility was 3.
데이터처리
Chi-square tests were performed for proportion of smoking status and alcohol consumption. An analysis of variance (ANOVA) was performed to assess the differences in baPWV levels according to metabolic syndrome. Pearsonfs correlation coefficients were calculated to evaluate the relationship between baPWV and clinical variables.
hs-CRP was logarithmically transformed prior to statistical testing to improve normality. Clinical and metabolic characteristics between genders of the study population were compared using the t~test for continuous variables. Chi-square tests were performed for proportion of smoking status and alcohol consumption.
Coefficients (r) and P-values were calculated by the Pearson correlation model.
P-values are calculated by t-test.
An analysis of variance (ANOVA) was performed to assess the differences in baPWV levels according to metabolic syndrome. Pearsonfs correlation coefficients were calculated to evaluate the relationship between baPWV and clinical variables. We used multiple linear regression analysis to the multivariates associations between baPWV as a dependent variable and CVD risk factors.
이론/모형
Blood samples were obtained from each participant after an 8-h overnight fast from an antecubital vein, and placed into plain vacutainer. High sensitivity C-reactive protein (hs-CRP), fasting glucose, total cholesterol, triglyceride, and HDL-cholesterol were measured by an AD VIA 1650 Chemistry system (Bayer, Tarrytowns NY USA), and LDL- cholesterol was calculated from the Friedewald equation (Friedewald et al., 1972). Fasting insulin was measured by electrochemilumi nescence immunoassay (Roche, Indianapolis, IN, USA).
성능/효과
In conclusion, mean blood pressure, age, gender, and HOM-IR were associated with baPWV in young adults. It may be important to focus on multiple cardiovascular risk factors early in life.
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