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논문 상세정보

Abstract

Seven flavonoids were isolated from the whole plants and fruits of Cayratia japonica through the activity-guided isolation of a methanol extract using a monoamine oxidase (MAO) inhibition assay as a monitor. The chemical structures of the isolates were assigned as $apigenin-7-O-{\beta}-D-glucuronopyranoside$ (1), apigenin (2), luteolin (3), $luteolin-7-O-{\beta}-D-glucopyranoside$ (4), (+)-dihydroquercetin (taxifolin) (5), (+)-dihydrokaempferol (aromadendrin) (6) and quercetin (7). Among the isolated compounds, flavones such as apigenin (2) and luteolin (3), as well as the flavonol, quercetin (7) showed potent inhibitory effects against the MAO activity with $IC_{50}$ values of 6.5, 22.6, and $31.6{\mu}M$, respectively. However, the flavone glycosides, $apigenin-7-O-{\beta}-D-glucuronopyranoside$ (1) and $luteolin-7-O-{\beta}-D-glucopyranoside$ (4), showed mild MAO inhibition ($IC_{50}$ values: 81.7 and $118.6{\mu}M$, respectively). The flavanonol derivatives, taxifolin (5) and aromadendrin (6), also showed weak inhibition ($IC_{50}$ values: 154.7 and $153.1{\mu}M$, respectively). Furthermore, quercetin (7) had a more potent inhibitory effect on MAO-A ($IC_{50}$ value: $2.8{\mu}M$) than MAO-B ($IC_{50}$ value: $90.0{\mu}M$). Apigenin (2) and luteolin (3) also preferentially inhibited MAO-A ($IC_{50}$ values: 1.7 and $4.9{\mu}M$, respectively) compared with MAO-B ($IC_{50}$ values: 12.8 and $59.7{\mu}M$, respectively).

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이 논문을 인용한 문헌 (4)

  1. Choi, Jang-Gi ; Hur, Jong-Moon ; Cho, Hyun-Woo ; Park, Jong-Cheol 2007. "Phenolic Compounds from Capsiccum annuum Leaves Showing Radical Scavenging Effect" 생약학회지, 38(3): 258~262 
  2. Yang, Hee-Jung ; Kim, Eun-Hee ; Park, Soo-Nam 2008. "Antioxidative Activity and Component Analysis of Cayratia japonica Extract" 大韓化粧品學會誌 = Journal of the society of cosmetic scientists of Korea, 34(2): 117~127 
  3. 2010. "" Bulletin of the Korean Chemical Society, 31(1): 227~229 
  4. 2010. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 33(6): 875~880 

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