$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

GC/MS-SIM을 이용한 우리나라 수중 생물시료 중 알킬페놀, 클로로페놀과 비스페놀 A의 분석을 위한 냉동필터법의 응용

Application of Freezing Filtration Method to the Analysis of Alkylphenols, Chlorophenols and Bisphenol a in Korean Aquatic Biological Samples Using GC/MS-SIM

초록

우리나라 수중 생물시료에 있는 알킬페놀류, 클로로페놀류 및 비스페놀 A의 정량분석을 위한 새로운 기술을 제시하였다. 우리나라 수중 생물시료에 있는 알킬페놀류, 클로로페놀류 및 비스페놀 A를 아세토니트릴로 추출한 다음 아세토니트릴 층을 2 시간동안 $-60^{\circ}C$에 냉동하였다(냉동필터). 또한, XAD-4를 이용한 고체상 추출 후, isobutoxycarbonyl(isoBOC) 또는 tert-butyldimethylsilyl(TBDMS) 유도체화 한 후 가스크로마토그래피/질량분석기-선택이온 모니터링 방법을 사용하였다. isoBOC 유도체화와 TBDMS 유도체화의 회수율은 $70.1\sim150.6%$$93.8\sim108.3%$이였으며, 선태이온 모니터링 방법을 이용한 비스페놀 A의 분석방법 검출한계는(MDLs) 각각 $0.062{\mu}g/kg$$0.010{\mu}g/kg$이었다 이 방법을 우리나라 수중 생물시료에 적용하였을 때, 11가지 페놀성 내분비계장애물질의 농도는 $0.675\sim1.970{\mu}g/kg$이었다.

Abstract

A new technique was proposed for the determination of alkylphenols, chlorophenols and bisphenol A in korean aquatic biological samples. The alkylphenols, chlorophenols and bisphenol A in korean aquatic biological samples were extracted with acetonitrile and then acetonitrile layer was refrigerated at $-60^{\circ}C$ for 2 hours(freezing filtration method). Also, solid-phase extraction(SPE) was used to XAD-4 and subsequent conversion to isobutoxycarbonyl(isoBOC) or tert-butyldimethylsilyl(TBDMS) derivatives for sensitive analysis with gas chromatography/mass spectrometry-selected ion monitoring(GC/MS-SIM) mode. For isoBOC derivatization and TBDMS derivatization the recoveries were $70.1\sim150.6%$ and $93.8\sim108.3%$, the method detection limit(MDLs) of bisphenol A for SIM were $0.062{\mu}g/kg$ and $0.010{\mu}g/kg$, and the SIM respectively. When these methods were applied to korean aquatic biological samples, the concentrations of the 11 phenolic EDCs were $0.675\sim1.970{\mu}g/kg$.

저자의 다른 논문

참고문헌 (32)

  1. 'Japan Environment Agency, Strategic Programs on Environmental,' JEA, Tokyo, May, 68-77(1998) 
  2. Philip, B. D., Chi-Su, C., and Joseph, J. G., 'Degradation of bisphenol A in natural waters,' Chemosphere, 16, 1501-1507(1987) 
  3. Hong, J., Eo, Y., Rhee, J., Kim T., and Kim K., 'Simultaneous analysis of 25 pesticides in crops using gas chromatography and their identification by gas chromatography-mass spectrometry,' J. Chromatogr., 639, 261-271(1993) 
  4. 김협, 홍종기, 김용화, 김경례, '기체 크로마토그래피/질량분석기를 이용한 field-screening 적용을 위한 알킬페놀류, 클로로페놀류 및 비스페놀 A의 isoBOC 유도체, TBDMS 유도체와 US EPA 방법의 비교,' 분석과학회지, 15(3), 196-213(2002) 
  5. Shin, H.-S., Park, C.-H., Park, S.-J., Pyo, H.-S., 'Sensitive determination of bisphenol A in environmental water by gas chromatography with nitrogen-phosphorus detection after cyanomethylation,' J. Chromatogr. A, 912, 119-125(2001) 
  6. Moder, M., Schrader, S., Franck, U., and Popp, P., 'Determination of phenolic compounds in water by solidphase micro extraction,' Fresenius J. Anal Chem., 357, 326-332(1997) 
  7. 'EPA method 625, Base/neutrals and acids,' EPA Test Methods, 127-139(1998) 
  8. Dachs, J., Van Ry, D. A., and Eisenreich, S. J., 'Occurrence of Estrogenic Nonylphenols in the Urban and Coastal Atmosphere of the Lower Hudson River Estuary,' Environ. Sci. Technol., 33, 2676-2679(1999) 
  9. Cook, J. C., Kaplan, A. M., Davis, L. G., and O'conner, J. C., 'Development of a Tier I Screening Battery for Detecting Endocrine-Active Compound(EACs),' Regul. Toxicol. Pharmacol., 26, 60-68(1997) 
  10. Achilli, G., Celrino, G. P., d'Eril, G. M., and Bird, S., 'Simultaneous determination of 27 phenols and herbicides in water by high-performance liquid chromatography with muti-electrode electrochemical detection,' J. Chromatogr. A, 697, 357-362(1995) 
  11. Cline, R. E., Todd, G. D., Ashley, D. L., Grainger, J., McCraw, J. M., Alley, C. C., and Hill, R. H., 'Gas chromatographic and spectral properties of pentafluorobenzyl derivatives of 2,4-dichlorophenoxyacetic acid and Metabolite,' J. Chromatogr. Sci., 28, 167-172(1990) 
  12. Lee, H. B., Weng, L. D., and Chau, A S. Y., 'Chemical Derivatization Analysis of Pesticide Residues. IX. Analysis of Phenol and 21 Chlorinated Phenols in Natural Waters by Formation of Pentafluorobenzyl Ether Derivatives,' J. ASSOC OFF. ANAL. CHEM., 67(6), 1086-1091(1984) 
  13. Lee, H. B., Stokker, Y. D., and Chau, A S. Y., 'Analysis of Phenols by Chemical Derivatization. V. Determination of Pentachlorophenol and 19 Other Chlorinated Phenols in Sediments,' J. ASSOC. OFF. ANAL. CHEM., 70(6), 1003-1008(1987) 
  14. Safe, S. H., 'Endocrine disruptors and human health is there a problem? An update,' Environ Health Perspect, 108, 487-493(2000) 
  15. Pavlov, B. and Terentyev, 'Organic Chemistry,' Gordon and Breach Science Publishers, New York, 125-127 (1965) 
  16. 김협, 김진호, '기체 크로마토그래피/질량분석기를 이용한 종이류 중 알킬페놀류, 클로로페놀류 및 비스페놀 A 정량,' 환경독성학회지, 18(1), 45-55(2003) 
  17. Kim, K.-R. and Kim, H., 'Gas chromatographic profiling and screening for phenols as isobutoxycarbonyl derivatives in aqueous samples,' J. Chromatogr. A, 866, 87-96(2000) 
  18. Boyd, Th. J., 'Indentification and quantification of mono-, di- and trihydroxybenzenes(phenols) at trace concentrations in seawater by aqueous acetylation and gas chromatographic-mass spectrometric analysis,' J. Chromatogr., 662, 281-292(1994) 
  19. Jones, P. A., 'Chlorophenols and Their Impurities in the Canadian Environment,' Environment Canada Econ. Tech. Rev. Report EPS-3-EC-81-2, 434(2000) 
  20. Heberer, T. and Stan, H. J., 'Detection of more than 50 substituted phenols as their t-butyldimethylsilyl derivatives using gas chromatography-mass spectrometry,' Analytica Chemica Acta, 341, 21-34(1997) 
  21. Rodriguez, I., Mejuto, M. C., Bollain, M. H., and Cela, R., 'Evaluation of two solid-phase extraction procedures for the preconcentration of chlorophenols in drinking water,' J. Chromatogr. A, 786, 285-292(1997) 
  22. Masque, N., Pocurull, E., Marce, R. M., and Borrull, F., 'Determination of eleven priority EPA phenolics at ng L-1 levels by on-line solid-phase extraction and liquid chromatography with UV and electrochemical detection,' Chromatographia, 47, 176-182(1998) 
  23. Helaleh, M. I. H., Takabayashi, Y., Fujii, S., and Korenaga, T., 'Gas chromatographic-mass spectrometric method for separation and detection of endorcrine disruptors from environmental water samples,' Analytica Chemica Acta, 428, 227-234(2001) 
  24. Penalver, A., Pocurull, E., Borrull, F., Marce, R. M., 'Solid-phase microextraction coupled to high-performance liquid chromatography to determine phenolic compounds in water samples,' J. Chromatogr. A, 97, 382-390(2002) 
  25. Tsuda, T., Takino, A., Kojima, M., Harada, H., and Muraki, K., 'Gas chromatographic - mass spectrometric determination of 4-nonylphenols and 4-tert-octylphenol in biological samples,' J. Chromatogr. B, 723, 273-279 (1999) 
  26. Yergey, A. L., Edmonds, C. G., Lewis, I. A. S., and Vestal, M. L., 'Liquid Chromatography/Mass Spectrometry,' Plenum Press, New York(1990) 
  27. 'Developmental Effects of Endocrine Disrupting Chemicals in Wildlife and Humans. EHP,' Illinois EPA Endocrine Disruptors Strategy, 101(5), 378-384(1993) 
  28. 'EDSTAC, Endocrine Disruptor Screening and Testing Advisory Committee(EDSTAC) Final Report,' August 1(1998) 
  29. Kim, H., Hong, J., Kim, Y. H., and Kim K. R., 'Combined isobutoxycarbonylation and tert-butyldimethylsilylation for the GC/MS-SIM detection of alkylphenols, chlorophenols and bisphenol A in mackerel samples,' Arch. Pharm. Res., 26(9), 697-705(2003) 
  30. Lee, H. B., You, R. L. H., and Fowlie, P. J. A, 'Chemical derivatization Analysis of Phenols. Part VI. Determination of chlorinated phenolics in Pulp and paper effluents,' J. ASSOC. OFF. ANAL. CHEM., 72(6), 979-984(1989) 
  31. Staples, C. A., Dome, P. B., Klecka, G. M., Oblock S. T.. and Harris L. R., 'A review of the environmental fate, effects, and exposures of bisphenol A,' Chemosphere, 36, 2149-2173(1998) 
  32. Afghan, B. K., Carron, J., Goulden, P. D., Lawrence, J., Leger, D., Onuska, F., Sherry, J., and Willkinson, R., 'Recent advances in ultratrace analysis of dioxins and related halogenated hydrocarbons,' Can. J. Chem., 65, 1086-1097(1987) 

이 논문을 인용한 문헌 (0)

  1. 이 논문을 인용한 문헌 없음

DOI 인용 스타일