• 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보


Gentamicin is a broad-spectrum aminoglycoside antibiotic used in the treatment of bacterial infection. Although side effects of gentamicin such as nephrotoxicity and ototoxicity have been investigated, the information on the hepatic effects of gentamicin is still limited. In the present study, gene expression profiles were analyzed in the liver of gentamicin treated mice using Affymetrix GeneChip$^{(R)}$ Mouse Expression 430A 2.0 Array. Totally, 400 genes were identified as being either up- or down-regulated over 1.5-fold changes (P<0.01) in the liver of gentamicin treated mice. Among these deregulated genes, 16 up-regulated genes mainly involved in transport (Kif5b, Pex14, Rab14, Clcn3, and Necap1) and 20 down-regulated genes involved in lipid and other metabolisms (Hdlbp, Gm2a, Uroc1, and Dak) were selected using k-means clustering algorithm. The functional classification of differentially expressed genes represented that several stress-related genes were regulated in the liver by gentamicin treatment. This data may contribute in understanding the molecular mechanism in the liver of gentamicin treated mice.

참고문헌 (18)

  1. Ali, B. H. Gentamicin nephrotoxicity in humans and animals: some recent research. Gen. Pharmacol. 26(7):1477-1487 (1995) 
  2. Selimoglu, E. Aminoglycoside-induced ototoxicity. Curr. Pharm. Des. 13(1):119-126 (2007) 
  3. Oh, J. H. et al. Gene expression profiling of early renal toxicity induced by gentamicin in mice. Mol. Cell. Toxicol. 2(3):185-192 (2006) 
  4. Kohn, S. et al. Hepatotoxicity of combined treatment with cisplatin and gentamicin in the guinea pig. Ultrastruct Pathol. 29(2):129-137 (2005) 
  5. Kohn, S. et al. Toxic effects of cisplatin alone and in combination with gentamicin in stria vascularis of guinea pigs. Laryngoscope 101(7 Pt 1):709-716 (1991) 
  6. Kohn, S. et al. Nephrotoxicity of combined treatment with cisplatin and gentamicin in the guinea pig: glomerular injury findings. Ultrastruct Pathol. 26(6): 371-382 (2002) 
  7. Kohn, S. et al. Endothelial injury of capillaries in the stria vascularis of guinea pigs treated with cisplatin and gentamicin. Ultrastruct Pathol. 21(3):289-299 (1997) 
  8. Powell, C. L. et al. Phenotypic anchoring of acetaminophen- induced oxidative stress with gene expression profiles in rat liver. Toxicol. Sci. 93(1):213-222 (2006) 
  9. Chung, H. et al. Comprehensive analysis of differential gene expression profiles on carbon tetrachlorideinduced rat liver injury and regeneration. Toxicol. Appl. Pharmacol. 206(1):27-42 (2004) 
  10. Oda, H. et al. Microarray analysis of the genes induced by tetracycline-regulated expression of NDRF/ NeuroD2 in P19 cells. Biochem. Biophys. Res. Commun. 335(2):458-468 (2005) 
  11. Waring, J. F. et al. Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles. Toxicol. Appl. Pharmacol. 175(1):28-42 (2001) 
  12. Harris, A. J. et al. Comparison of basal gene expression profiles and effects of hepatocarcinogens on gene expression in cultured primary human hepatocytes and HepG2 cells. Mutation Research 549:79-99 (2004) 
  13. Hartley, D. P. et al. Activators of the rat pregnave X receptor differentially modulate hepatic and intestinal gene expression. Molecular Pharmacology 65:1159- 1171 (2004) 
  14. Heijne, W. H. et al. Bromobenzene-induced hepatotoxicity at the transcriptome level. Toxicology Sciences 79:411-422 (2004) 
  15. Huang, Q. et al. Gene expression profiling reveals multiple toxicity endpoints induced by hepatotoxicants. Mutation Research 549:147-167 (2004) 
  16. Mor, F. et al. Prospective evaluation of liver function tests in patients treated with aminoglycosides. DICP Ann. Pharmacother. 24:135-137 (1990) 
  17. Corcoran et al. Early sustained rise in total liver calcium during acetaminophen hepatotoxicity in mice. Res. Commun. Chem. Pathol. Pharmacol. 58(3):291- 305 (1987) 
  18. Hwang, J. Y. et al. Toxicogenomics study on $\alpha$-Naphthylisothiocyanate (ANIT) induced hepatotoxicity in mice. Mol. Cell. Toxicol. 2(1):48-53 (2006) 

이 논문을 인용한 문헌 (1)

  1. 2009. "" Toxicological research, 25(2): 85~92 


원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

  • 원문 URL 링크 정보가 존재하지 않습니다.

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. 원문복사서비스 안내 바로 가기

상세조회 0건 원문조회 0건

DOI 인용 스타일