$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

Abstract

Chronic formaldehyde inhalation studies have suggested its relativity to teratogenicity, cancer incidence, neurodegenerative and vascular disorders. Many toxicological data on the formaldehyde toxicity are available, but proteomic results showing complete protein profiles are limited. Therefore, alterations of protein expression patterns upon formaldehyde treatment were investigated in the human lung epithelial cell line. Differentially expressed proteins following formaldehyde treatment were analyzed on 2-dimensional gels, and further analyzed by MALDI-TOF to identify the proteins. Among the identified proteins, 24 proteins were notably up-regulated and 6 proteins were down-regulated. In particular, cytoskeleton related protein named vinculin and Rho GDP dissociation inhibitor which plays a key role in apoptosis increased remarkably.

참고문헌 (30)

  1. International Agency for Research on Cancer, On-line database, December (2006) 
  2. Hester, S. D. et al. Formaldehyde-induced gene expression in F344 rat nasal respiratory epithelium. Toxicology 187:13-24 (2003) 
  3. Hauptmann, M. et al. Mortality from solid cancers among workers in formaldehyde industries. Am J Epidemiol 159:1117-1130 (2004) 
  4. Vaughan, T. L. et al. Occupational exposure to formaldehyde and wood dust and nasopharyngeal carcinoma. Occup Envion Med 57:376-384 (2000) 
  5. Fella, K. et al. Use of two-dimensional gel electrophoresis in predictive toxicology: identification of potential early protein biomarkers in chemically induced hepatocarcinogenesis. Proteomics 5:1914-1927 (2005) 
  6. Tyihak, E. et al. Formaldehyde promotes and inhibits the proliferation of cultured tumour and endothelial cells. Cell Prolif 34:135-141 (2001) 
  7. Marx, C. J., Christoserdova, L. & Lidstrom, M. E. Formaldehyde- detoxifying role of the tetrahydromethanopterin-linked pathway in Methylobacterium extorquens AM1. Bacteriol 185:7160-7168 (2003) 
  8. Walkup. A. S. & Appling, D. R. Enzymatic characterization of human mitochondrial C1-tetrahydrofolate synthase. Arch Biochem Biophys 442:196-205 (2005) 
  9. Sanghani, P. C., Robinson, H., Bosron, W. F. & Hurley, T. D. Human glutathione-dependent formaldehyde dehydrogenase. Structures of apo, binary, and inhibitory ternary complexes. Biochemistry 41:10778-10786 (2002) 
  10. Laouini, D. et al. COX-2 inhibition enhances the TH2 immune response to epicutaneous sensitization. J Allergy Clin Immunol 116:390-396 (2005) 
  11. Takahashi, S. et al. Prospective study of clinical symptoms and skin test reactions in medical students exposed to formaldehyde gas. J Dermatol 34:283-289 (2007) 
  12. Ayaki, H., Lee, M. J., Sumino, K. & Nishino, H. Different cytoprotective effect of antioxidants and change in the iron regulatory system in rodent cells exposed to paraquat or formaldehyde. Toxicology 208:73-79 (2005) 
  13. Saito, Y., Nishio, K., Yoshida, Y. & Niki, E. Cytotoxic effect of formaldehyde with free radicals via increment of cellular reactive oxygen species. Toxicology 210:235-245 (2005) 
  14. Quievryn, G. & Zhitkovich, A. Loss of DNA-protein crosslinks from formaldehyde-exposed cells occurs through spontaneous hydrolysis and an active repair process linked to proteosome function. Carcinogenesis 21:1573-1580 (2000) 
  15. Zhong, W. & Que Hee, S. S. Formaldehyde-induced DNA adducts as biomarkers of in vitro human nasal epithelial cell exposure to formaldehyde. Mutat Res 563:13-24 (2004) 
  16. Cheng, G. et al. Reactions of formaldehyde plus acetaldehyde with deoxyguanosine and DNA: formation of cyclic deoxyguanosine adducts and formalde-hyde crosslinks. Chem Res Toxicol 16:145-152 (2003) 
  17. Kim, Y. J. et al. Genotoxicity and identification of differentially expressed genes of formaldehyde in human jurkat cells. Mol Cell Toxicol 1:230-236 (2005) 
  18. Speit, G. & Merk, O. Evaluation of mutagenic effects of formaldehyde in vitro: detection of crosslinks and mutations in mouse lymphoma cells. Mutagenesis 17:183-187 (2002) 
  19. Dowling, V. A. & Sheehan, D. Proteomics as a route to identification of toxicity targets in environmental toxicology. Proteomics 6:5597-5604 (2006) 
  20. Metz, B. et al. Identification of formaldehyde-induced modifications in proteins: reactions with model peptides. J Bio Chem 279:6235-6243 (2004) 
  21. Wonsey, D. R., Zeller, K.I. & Dang, C.V. The c-Myc target gene PRDX3 is required for mitochondrial homeostasis and neoplastic transformation. Proc Nat Acad Sci 99:6649-6654 (2002) 
  22. Leffers, H. et al. Identification of two human Rho GDP dissociation inhibitor proteins whose overexpression leads to distruption of the actin cytoskeleton. Exp Cell Res 209:165-174 (1993) 
  23. Togawa. A. et al. Progressive impairment of kidneys and reproductive organs in mice lacking Rho GDI$\alpha$. Oncogene 18:5373-5380 (1999) 
  24. Hu, K. et al. Differential transmission of actin motion within focal adhesion. Science 315:111-115 (2007) 
  25. Ahmad, M. K., Roderick, J. F. & Mauro, P. An overview of the effects of annexin 1 on cells involved in the inflammatory process. Mem Inst Oswaldo Cruz 100:39-48 (2005) 
  26. Buckingham, J. C. et al. Annexin 1, glucocorticoids and the neuroendocrine immune interface. Ann N Y Acad Sci 1088:396-409 (2006) 
  27. Fukuoka, S. I., Kern, H., Kazuki, S. R. & Ikeda, Y. Cloning and characterization of ZAP36, an annexinlike, zymogen granule membrane associated protein, in exocrine pancreas. Biochim Biophys Acta 1575: 148-152 (2002) 
  28. Damsker, J. M., Bukrinsky. M. I. & Constant, S. L. Preferential chemotaxis of activated human CD4+ T cells by extracellular cyclophilin A. J Leukoc Biol 82: 613-618 (2007) 
  29. Lee, S. J. et al. Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain. J Biol Chem 278:44552-44559 (2003) 
  30. Kim, Y. K., Yoo, W. I., Lee, S. H. & Lee, M. Y. Proteomic analysis of cadmium-induced protein profiled alterations from marine alga Nannochloropsis oculata. Ecotoxicology 14:589-596 (2005) 

이 논문을 인용한 문헌 (3)

  1. 2008. "" 한국응용생명화학회지 = Journal of the Korean Society for Applied Biological Chemistry, 51(4): 269~275 
  2. 2008. "" Molecular & cellular toxicology, 4(3): 253~259 
  3. 2009. "" BMB reports, 42(7): 456~461 

원문보기

원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

  • 원문 URL 링크 정보가 존재하지 않습니다.

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

이 논문과 연관된 기능

DOI 인용 스타일