$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

신부전증의 개에서 혈중 칼슘/무기인과 부갑상샘 호르몬의 관계

Relationship between Calcium/Inorganic Phosphorus and Parathyroid Hormone Concentrations in Dogs with Renal Failure

초록

부갑상샘 호르몬 (PTH)은 칼슘과 무기인의 수송을 조절한다. 속발성 부갑상샘 기능항진증은 대개 만성신부전에서 발생하고, 이는 개와 고양이에 있어서 CRF의 일반적인 합병증이다. 신부전을 갖는 21마리의 개가 본 연구에 사용되었다. 공시동물로부터 채혈한 혈액 중 칼슘 (Ca),무기인 (iP), PTH의 농도를 측정하여 칼슘과 무기인의 비율에 따라 두 군으로 분류하였다 (Ca / iP $\leq$ I; 그룹 1, Ca/ip $\geq$ 1.5; 그룹 II). 성과 연령 사이에 부갑상샘 호르몬 수준은 유의성 있는 차이가 없었다. 두 군 사이에 부갑상샘 호르몬 수준과 Ca/P의 비율에는 유의성 (p<0.0001)있는 차이가 나타났다. 결론적으로, 칼슘과 무기인의 비율은 신부전을 갖는 개에서 부갑상샘 호르몬 수준을 예측하기 위한 지표로 이용될 수 있을 것으로 생각된다.

Abstract

Parathyroid hormone (PTH) regulates calcium (Ca) and phosphate transport. Secondary hyperparathyroidism usually occur in chronic renal failure (CRF), and it is a common complication of CRF in dogs and cats. Twenty one dogs with renal failure were enrolled in this study. Plasma Ca, inorganic phosphorus (iP) and PTH concentrations were measured. Dogs were divided into two groups by the ratio of Ca to iP (Ca/iP$\leq$1; Group I, Ca/iP$\leq$1.5; Group II). The PTH level between sexes ages were not significantly different. The PTH level and Ca/iP between two groups were significantly different (p < 0.0001). In conclusion, The ratio of Ca to iP may be considered as useful surrogator to predict PTH level of dogs with renal failure.

참고문헌 (23)

  1. Albaaj F, Hutchison A. Hyperphosphataemia in renal failure: causes, consequences and current management. Drugs 2003; 63: 577-596 
  2. Allgrove J. Disorders of calcium metabolism. Current Paediatrics 2003; 13: 529-535 
  3. Birchard SJ, Sherding RJ. Saunders manual of small animal practice. Philadelphia: WB saunders. 2000: 913-924 
  4. Brown SA. Manual of canine and feline nephrology and urology. In: Chronic renal failure; Recent Developments in Medical Management, Gloucestershire: BSAVA. 1996: 195-203 
  5. Ettinger SJ, Feldman EC. Textbook of Veterinary Internal Medicine. Philadelphia: WB Saunders. 2000: 1511-1516 
  6. Felsenfeld AJ. Considerations for the treatment of secondary hyperparathyroidism in renal failure. J Am Soc Nephrol 1997; 8: 993-1004 
  7. Finco DR, Brown SA, Crowell WA, Groves CA, Duncan JR, Barsanti JA. Effects of phosphorus/calcium-restricted and phosphorus/calcium-replete 32% protein diets in dogs with chronic renal failure. Am J Vet Res 1992; 53: 157-163 
  8. Gerber B, Hassig M, Reusch CE. Serum concentrations of 1,25-dihydroxycholecalciferol and 25-hydroxycholecalciferol in clinically normal dogs and dogs with acute and chronic renal failure. Am J Vet Res 2003; 64: 1161-1166 
  9. John B, Jonathan E. Manual of Canine and Feline Nephrology and Urology. Gloucestershire: BSAVA. 1996: 117-123, 185 
  10. Kruger JM, Osborne CA, Nachreiner RF, Refsal KR. Hypercalcemia and renal failure. Etiology, pathophysiology, diagnosis, and treatment. Vet Clin North Am Small Anim Pract 1996; 26: 1417-1445 
  11. Lee E, Tahara H, Shoji T, Nagata M, Ueda M, Yamada S, Goto H, Inaba M, Nishizawa Y. [Case Report No.138:One case of advanced renal hyperparathyroidim complicated with acute renal failure.]. Clin Calcium 2004; 14: 462-465 
  12. Martinez I, Saracho R, Montenegro J, Llach F. The importance of dietary calcium and phosphorous in the secondary hyperparathyroidism of patients with early renal failure. Am J Kidney Dis 1997; 29: 496-502 
  13. Meuten DJ, Chew DJ, Capen CC, Kociba GJ. Relationship of serum total calcium to albumin and total protein in dogs. J Am Vet Med Assoc 1982; 180: 63-67 
  14. Morgan RV. Handbook of Small Animal Practice. Philadelphia: WB Saunders. 1992: 573 
  15. Neuser D, Hirth-Dietrich C, Stasch JP, Kazda S. Influence of calcium antagonists on renal function and secondary hyperparathyroidism in acute renal failure in rats. Ren Fail 1990; 12: 221-225 
  16. Petrites-Murphy MB, Pierce KR, Lowry SR, Fisher JW. Role of parathyroid hormone in the anemia of chronic terminal renal dysfunction in dogs. Am J Vet Res 1989; 50: 1898-1905 
  17. Reusch CE, Tomsa K, Zimmer C, Hoerauf A, Nett C, Unterer S, Glaus TM, Schlittner E, Pospischil A. Ultrasonography of the parathyroid glands as an aid in differentiation of acute and chronic renal failure in dogs. J Am Vet Med Assoc 2000; 217: 1849-1852 
  18. Schenck PA, Chew DJ. Determination of calcium fractionation in dogs with chronic renal failure. Am J Vet Res 2003; 64: 1181-1184 
  19. Slatopolsky E, Caglar S, Pennell JP, Taggart DD, Canterbury JM, Reiss E, Bricker NS. On the pathogenesis of hyperparathyroidism in chronic experimental renal insufficiency in the dog. J Clin Invest 1971; 50: 492-499 
  20. Sodikoff CH. Laboratory Profiles of Small Animal Diseases. Mosby. 1995: 35 
  21. Weller RE, Cullen J, Dagle GE. Hyperparathyroid disorders in the dog: primary, secondary and cancer-associated (pseudo). J Small Anim Prat 1985; 26: 329-341 
  22. White JV, Finco DR, Crowell WA, Brown SA, Hirakawa DA. Effect of dietary protein on functional, morphologic, and histologic changes of the kidney during compensatory renal growth in dogs. Am J Vet Res 1991; 52: 1357-1365 
  23. Yasunaga C, Matsuo K, Yanagida T, Matsuo S, Nakamoto M, Goya T. Early effects of parathyroidectomy on erythropoietin production in secondary hyperparathyroidism. Am J Surg 2002; 183: 199-204 

이 논문을 인용한 문헌 (0)

  1. 이 논문을 인용한 문헌 없음

DOI 인용 스타일