Abstract

A novel fiber optic surface plasmon resonance (SPR) sensor using cyclic olefin copolymer (COC) prism with the spectral modulation is presented. The SPR sensor chip is fabricated using the SU-8 photolithography, Ni-electroplating and COC injection molding process. The sidewall of the COC prism is partially deposited with Au/Cr (45/2.nm thickness) by e-beam evaporator, and the thermal bonding process is conducted for micro fluidic channels and optical fibers alignment. The SPR spectrum for a phosphate buffered saline (0.1.M PBS, pH.7.2) solution shows a distinctive dip at 1300.nm wavelength, which shifts toward longer wavelength with respect to the bovine serum albumin (BSA)concentrations. The sensitivity of the wavelength shift is $1.16\;nm{\cdot}{\mu}g^{-1}{\cdot}{\mu}l^{-1}$. From the wavelength of SPR dips, the refractive indices (RI) of the BSA solutions can be theoretically calculated using Kretchmann configuration, and the change rate of the RI was found to be $2.3{\times}10^{-5}RI{\cdot}{\mu}g^{-1}{\cdot}l^{-1}$. The realized fiber optic SPR sensor with a COC prism has clearly shown the feasibility of a new disposable, low cost and miniaturized SPR biosensor for biochemical molecular analyses.

주제어

#fiber optic   #cyclic olefin copolymer (COC)   #surface plasmon resonance (SPR) sensor   #polymer prism  

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참고문헌 (8)

1. L. Chau, Y. Lin, S. Cheng, and T. Lin, "Fiber-optic chemical and biochemical probes based on localized surface plasmon resonance", Sensors and Actuators B, vol. 113, pp. 100-105, 2006 
2. J.-W. Choi, S. Kim, R.Trichur, H. J. Cho, A. Puntambekar, R. L. Cole, J. R. Simkins, S. Murugesan, K. S. Kim, J. B. Lee, G. Beaucage, J. H. Nevin, and C. H. Ahn, "A plastic micro injection molding technique using replaceable mold-disks for disposable microfluidic systems and biochips", Proceedings of the 5th International Conference on Micro Total Analysis Systems (micro-TAS 2001), pp. 411-412, Monterey, CA, Oct. 21-25, 2001 
3. E. Kretchmann and H. Rather, "adiative decay of nonradiative surface plasmons excited by light", Z. Naturforsch. A vol. 23, pp. 2135-2136, 1968 
4. L. A. Obando, D. J. Gentleman, J. R. Holloway, and K. S. Booksh, "Manufacture of robust surface plasmon resonance fiber optic based dip-probes", Sensors and Actuators B, vol. 100, pp. 439-449, 2004 
5. 이훈, 이승기, "광섬유 국소화 표면 플라즈몬 공명 센 서를 위한 광섬유 표면상의 금속 나노 입자 형성", 센서학회지, 제17권, 제2호, pp. 95-99, 2008  원문보기 상세보기
6. X. D. Hoa, A. G. Kirk, and M. Tabrizian, "Toward integrated and sensitive surface plasmon resonance biosensors: A review of recent progress", Biosensors and bioelectronics, vol. 23, pp. 151-160, 2007 
7. M. Piliarik, J. Homola, Z. Manikova, and J. Ctyroky, "Surface plasmon resonance sensor based on single-mode polarization-maintaining optical fiber", Sensors and Actuators B, vol. 90, pp. 236-242, 2003 
8. K.T. Kim, K. H. Lee, E. S. Shin, H. S. Song, K. B. Hong, S. Hwangbo, and K. R. Sohn, "Characteristics of side-polished thermally expanded core fiber and its application as a band-edge filter with a high cut-off property", Optics communications, vol. 261, pp. 51-55, 2006 

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