$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

Abstract

With the aim of increasing the $CoQ_{10}$ production in mass culture, the effect of aeration-agitation on the $CoQ_{10}$ production using Rhodobactor sphaeroides was investigated in a l-L bioreactor. The maximum $CoQ_{10}$ production was 1.69 mg/g of dry cell weight under conditions of 50 Lux, $30^{\circ}C$, 300 rpm, and 5-vvm aeration. The $CoQ_{10}$ production was improved to produce 2.91 mg/g of dry cell weight under reduced conditions of agitation speed (200 rpm) and aeration rate (0.2 vvm). When R. sphaeroides was cultivated under more reduced DO levels during the exponential phase of the cell, the $CoQ_{10}$ production yield of 3.88-mg/g dry cell weight was the maximum obtained. Therefore, poorer conditions of aeration-agitation resulted in higher production of $CoQ_{10}$, and thus DO content was a crucial factor in the production of $CoQ_{10}$. Accordingly, it was necessary to control the DO concentration in order to enhance the $CoQ_{10}$ biosynthesis within a large-scale production.

참고문헌 (26)

  1. James, A.M., R.A.J. Smith and M.P. Murphy. 2004. Anti-oxidant and prooxidant properties of mitochondrial coenzyme Q. Arch. Biochem. Biophys., 423, 47-56 
  2. Jeong, S.K., S.C. Ahn, I.S. Kong and J.K. Kim. 2008. Isolation and identification of a photosynthetic bac-terium containing high content of coenzyme $Q_{10}$. J. Fish. Sci. Technol., 11,172-176 
  3. Kuratu, Y., M. Sakurai, H. Hagino and K. Inuzuka. 1984. Aeration-agitation effect on coenzyme $Q_{10}$ production by Agrobacterium species. J. Ferment. Technol., 62, 305-308 
  4. Park, Y.C., S.J. Kim, J.H. Choi, W.H. Lee, K.M. Park, M. Kawamukai, Y.W. Ryu and J.H. Seo. 2005. Batch and fed-batch production of coenzyme $Q_{10}$ in recombinant Escherichia coli containing the decaprenyl diphos-phate synthase gene from Gluconobacter suboxydans. Appl. Microbiol. Biotechnol., 67, 192-196 
  5. Sasaki, K, T. Tanaka and S. Nagai. 1998. Use of photo-synthetic bacteria for production of SCP and chemi-cals from organic wastes. In: Bioconversion of waste materials to industrial products (2nd Edition). Martin, A.M., Ed. Blackie Academic and Professionals, New York, 247-291 
  6. Sasaki, K., M. Watanabe, Y. Suda, A. Ishizuka and N. Noparatnaraporn. 2005. Applications of photosynthe-tic bacteria for medical fields. J. Biosci. Bioeng., 100, 481-488 
  7. Takahashi, S., T. Nishino and T. Koyama. 2003. Isolation and expression of Paracoccus dentrificans decaprenyl diphosphate synthase gene for production of ubi-quinone-10 in Escherichia coli. Biochem. Eng. J., 16, 183-190 
  8. Urakami, T. and T. Yoshida. 1993. Production of ubi-quinone and bacteriochlorophyll $\alpha$ by Rhodobacter sphaeroides and Rhodobacter sulfidophilus. J. Fer-ment. Bioeng., 76, 191-194 
  9. Wu, Z., G. Du and J. Chen. 2003. Effects of dissolved oxygen concentration and DO-stat feeding strategy on Co$Q_{10}$ production with Rhizobium radiobacter. World J. Microbiol. Biotechnol., 19, 925-928 
  10. Yen, H.W. and C.H. Chiu. 2007. The influences of aerobic-dark and anaerobic-light cultivation on Co$Q_{10}$ production by Rhodobacter sphaeroides in the submerged fermenter. Enzyme Microb. Technol., 41, 600-604 
  11. Zhang, D., B. Shrestha, W. Niu, P. Tian and T. Tan. 2007. Phenotypes and fed-batch fermentation of ubiquin-one-overproducing fission yeast using ppt1 gene. J. Biotechnol., 128, 120-131 
  12. Ha, S.J., S.Y. Kim, J.H. Seo, H.J. Moon, K.M. Lee and J.K. Lee. 2007. Controlling the sucrose concentration in-creases Coenzyme $Q_{10}$ production in fed-batch cul-ture of Agrobacterium tumefaciens. Appl. Microbiol. Biotechnol., 76, 109-116 
  13. Grant, C.M., F.H. Maclver and I.W. Dawes. 1997. Mito-chondrial function is required for resistance to oxida-tive stress in the yeast Saccharomyces cerevisiae. FEBS Lett., 410, 219-222 
  14. Lipshutz, B.H., P. Mollard, S.S. Pfeiffer and W. Chrisman. 2002. A short, highly efficient synthesis of coenzyme $Q_{10}$. J. Am. Chem. Soc., 124, 14282-14283 
  15. Gale, P.H., F.R. Koniuszy, A.G. Page Jr. and K. Folkers. 1961. Coenzyme Q. XXIV. On the significance of coenzyme $Q_{10}$ in human tissues. Arch. Biochem. Biophys., 93, 211-213 
  16. Takeno, K., K. Sasaki and N. Nishio. 1999. Removal of phosphorus from oyster farm mud sediment using a photosynthetic bacterium, Rhodobacter sphaeroides IL106. J. Biosci. Bioeng., 88, 410-415 
  17. Lee, J.K., G. Her, S.Y. Kim and J.H. Seo. 2004. Cloning and functional expression of the dps gene encoding decaprenyl diphosphate synthase from Agrobacterium tumefaciens. Biotechnol. Prog., 20, 51-56 
  18. Saunders, V.A. and O.T.G. Jones. 1974. Properties of the cytochrome a-like material developed in the photosynthetic bacterium Rhodopseudomonas spheroides when grown aerobically. BBA- Bio-energetics, 333, 439-445 
  19. Kokua, H., I. Eroglu, U. Gunduz, M. Yucel and L. Turker. 2003. Aspects of the metabolism of hydrogen pro-duction by Rhodobacter sphaeroides. Int. J. Hydrogen Energy, 27, 1315-1329 
  20. Yamada, Y., K. Haneda, S. Murayama and S. Shiomi. 1991. Application of fuzzy control system fermentation. J. Chem. Eng., 24, 94-99 
  21. Wu, Z.F., P.F. Weng, G.C. Du and J. Chen. 2001. Advances of coenzyme $Q_{10}$ function studies. J. Ningbo Univ., 2, 85-88 
  22. Gu, S.B., J.M. Yao, Q.P. Yuan, P.J. Xue, Z.M. Zheng and Z.L. Yu. 2006. Kinetics of Agrobacterium tumefaciens ubiquinone-10 batch production. Process Biochem., 41, 1908-1912 
  23. Nagadomi, H., T. Kitamura, M. Watanabe and K. Sasaki. 2000. Simultaneous removal of chemical oxygen demand (COD), phosphate, nitrate and hydrogen sulphide in the synthetic sewage wastewater using porous ceramic immobilized photosynthetic bacteria. Biotechnol. Lett., 22, 1369-1374 
  24. Ernster, L. and G. Dallner. 1995. Biochemical, physiologi-cal and medical aspects of ubiquinone function. Biochim. Biophys. Acta, 1271, 195-204 
  25. Negishi, E., S.Y. Liou, C. Xu and S. Huo. 2002. A novel, highly selective, and general methodology for the synthesis of 1,5-diene-containing oligoisoprenoids of all possible geometrical combinations exemplified by an iterative and convergent synthesis of coenzyme $Q_{10}$. Org. Lett., 4, 261-264 
  26. Matsumura, M., T. Kobayashi and S. Aiba. 1983. Anaero-bic production of ubiquinone-10 by Paracoccus den-trificans. Eur. J. Appl. Microbiol. Biotechnol., 17, 85-89 

이 논문을 인용한 문헌 (0)

  1. 이 논문을 인용한 문헌 없음

원문보기

원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일