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초록

돌단풍 지상부를 80% MeOH로 추출하고, 얻어진 추출물을 EtOAc, n-BuOH 및 $H_2O$로 용매 분획하였다. 이 중 EtOAc 및 n-BuOH 분획으로부터 silica gel chromatography를 반복하여 5개의 화합물을 분리하였다. 각 화합물의 화학구조는 NMR, MS 및 IR 등의 스펙트럼 데이터를 해석하여, astragalin (1), kaempferol 3-O-${\alpha}$-L-rhamnopyranosyl (1${\rightarrow}$6)-${\beta}$-D-glucopyranoside (2), rutin(3), kaempferol 3-O-${\alpha}$-L-rhamnopyranosyl(1${\rightarrow}$4)-${\alpha}$-Lrhamnopyranosyl(1${\rightarrow}$6)-${\beta}$-D-glucopyranoside(4), quercetin 3-O-${\alpha}$-L-rhamnopyranosyl(1${\rightarrow}$4)-${\alpha}$-L-rhamnopyranosyl(1${\rightarrow}$6)-${\beta}$-Dglucopyranoside(5)로 동정하였다. 이들 화합물은 FPTase 활성을 억제하였으며, 특히 화합물 3(rutin)은 rat H-ras 세포주의 생장과 bFGF로 유도시킨 HUVECs의 cell migration을 억제하는 것으로 나타났다.

Abstract

The methanol extract from the aerial parts of Aceriphyllum rossii was fractionated into ethyl acetate, n-BuOH and $H_2O$ layers through solvent fractionation. Repeated silica gel column chromatography of EtOAc and n-BuOH layers afforded five flavonol glycosides. They were identified as astragalin (1), kaempferol 3-O-${\alpha}$-L-rhamnopyranosyl (1${\rightarrow}$6)-${\beta}$-D-glucopyranoside (2), rutin (3), kaempferol 3-O-${\alpha}$-L-rhamnopyranosyl (1${\rightarrow}$4)-${\alpha}$-L-rhamnopyranosyl 1${\rightarrow}$6)-${\beta}$-D-glucopyranoside (4), and quercetin 3-O-${\alpha}$-L-rhamnopyranosyl (1${\rightarrow}$4)-${\alpha}$-L-rhamnopyranosyl (1${\rightarrow}$6)-${\beta}$-D-glucopyranoside (5) on the basis of spectroscopic data. All of them showed an inhibition in farnesyl protein tranferase (FPTase) activity, and rutin (3) inhibited the growth of rat H-ras cell and the cell migration of human umbilical vein endothelial cells (HUVECs).

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이 논문을 인용한 문헌 (11)

  1. Yoon, Jin-A ; Hahm, Sahng-Wook ; Park, Ji-Eun ; Son, Yong-Suk 2009. "Total Polyphenol and Flavonoid of Fruit Extract of Opuntia humifusa and Its Inhibitory Effect on the Growth of MCF-7 Human Breast Cancer Cells" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 38(12): 1679~1684 
  2. 2009. "" Journal of the Korean Society for Applied Biological Chemistry, 52(3): 241~246 
  3. 2009. "" Journal of the Korean Society for Applied Biological Chemistry, 52(4): 321~326 
  4. Lim, Sang-Hyun ; Kim, Hee-Yeon ; Park, Min-Hee ; Park, Yu-Hwa ; Ham, Hun-Ju ; Lee, Ki-Yun ; Kim, Kyung-Hee ; Park, Dong-Sik ; Kim, Song-Mun 2010. "Biological Activities of Solvent Extracts from Leaves of Aceriphyllum rossii" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 39(12): 1739~1744 
  5. Lee, Young-Min ; Bae, Ji-Hyun ; Jung, Ho-Young ; Kim, Jae-Hyun ; Park, Dong-Sik 2011. "Antioxidant Activity in Water and Methanol Extracts from Korean Edible Wild Plants" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 40(1): 29~36 
  6. Cha, Yun-Yeop ; Sun, Seung-Ho ; Park, Won-Hyung ; Park, Dong-Sik ; Kim, Jae-Hyun ; Kim, Hee-Yeon ; Lim, Sang-Hyun ; Kim, Kyung-Hee 2011. "Single Oral Dose Toxicity of TB001 in Rats" 韓方再活醫學科學會誌 = Journal of oriental rehabilitation medicine, 21(4): 41~47 
  7. Cha, Yun-Yeop ; Sun, Seung-Ho ; Park, Won-Hyung ; Park, Dong-Sik ; Kim, Jae-Hyun ; Kim, Hee-Yeon ; Lim, Sang-Hyun ; Kim, Kyung-Hee 2011. "Single Oral Dose Toxicity of TB001 in Rats" 韓方再活醫學科學會誌 = Journal of oriental rehabilitation medicine, 21(4): 41~47 
  8. Park, Yu-Hwa ; Kim, Hee-Yeon ; Lim, Sang-Hyun ; Kim, Kyung-Hee ; Park, Dong-Sik ; Lee, Jung-Hoon ; Park, Chung-Geon ; Park, Chung-Berm ; Kim, Song-Mun 2011. "Effect of Aceriphyllum rossii Ethanol Extract on Lipid Metabolism in Rats Fed a High-Fat Diet" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 40(10): 1411~1416 
  9. Jung, Bok-Mi ; Shin, Mi-Ok ; Kim, Hyung-Rak 2012. "The Effects of Antimicrobial, Antioxidant, and Anticancer Properties of Opuntia humifusa Stems" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 41(1): 20~25 
  10. Park, Won Hyung ; Sun, Seung Ho ; Cha, Yun Yeop 2013. "Eficacy and Sfety Human Study of the Ethanol Extracts from Lythrum Salicaria L. and Aceriphyllum Rossii for Reducing Body Fat Percentage of Korean Adult" 동의생리병리학회지 = Journal of physiology & pathology in Korean Medicine, 27(6): 832~841 
  11. Kwon, Woo-Young ; Lee, Eun-Kyoung ; Yoon, Jin-A ; Chung, Kang-Hyun ; Lee, Kwon-Jai ; Song, Byeong Chun ; An, Jeung Hee 2014. "Quality Characteristics and Biological Activities of Vinegars Added with Young Leaves of Akebia quinata" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 43(7): 989~998 

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