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Inhibitory Effects of Panaxatriol from Panax ginseng C. A. Meyer on Phosphoinositide Breakdown Induced by Thrombin in Platelets 원문보기

Journal of ginseng research = 高麗人參學會誌, v.32 no.2, 2008년, pp.107 - 113  

Park, Kyeong-Mee (College of Oriental Medicine, Daejon University) ,  Rhee, Man-Hee (Department of Physiology, College of Veterinary Medicine, Kyungpook National University) ,  Shin, Han-Jae (KT&G Central Research Institute) ,  Song, Yong-Bum (KT&G Central Research Institute) ,  Hyun, Hak-Chul (KT&G Central Research Institute) ,  Park, Ki-Hyun (Korea Institute of Science and Technology Information) ,  Cho, Hyun-Jeong (Dream Pharma) ,  Choi, Sun-A (Postgraduate School of Medical Science, Busan National University) ,  Kang, Hyo-Chan (Department of Medicine Laboratory Science, College of Dong-Eui Institute of Technology) ,  Kim, Kyoung-Jin (Department of Food & Drug research, Ulsan Institute of Health & Environment) ,  Kim, Hyeong-Soo (Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, and Regional Research Center, Inje University) ,  Kang, Hee-Jin (Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, and Regional Research Center, Inje University) ,  Ok, Woo-Jeong (Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, and Regional Research Center, Inje University) ,  Lee, Dong-Ha (Department of Biomedical Laborat) ,  Park, Hwa-Jin

Abstract AI-Helper 아이콘AI-Helper

In this study, we have investigated the effect of panaxatriol (PT) on phosphoinositides (PIS) breakdown and $Ca^{2+}$-elevation in thrombin-induced platelet aggregation. Thrombin (5U/ml), a potent platelet agonist which activates phospholipase $C_{\beta}$ via protease activated...

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  • e: thrombin-activated platelets. The phospholipids (PLS) were separated by scraping each PLS band in TLC, and were used to investigate the metabolism of PIS.

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  • (Buckinghamshire, UK). Platelet-rich plasma (PRP), obtained from the antecubital vein of normal healthy human volunteers, was purchased from Taejon Red Cross Blood Center, Korea.
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참고문헌 (25)

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