$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

Abstract

Purpose: The present study was aimed to examine the effect of acellular dermal matrix ($AlloDerm^{(R)}$) grafted to the experimental tissue defect on tissue regeneration. Materials and Methods: Male albino rabbits were used. Soft tissue defects were prepared in the external abdominal oblique muscle. The animals were then divided into 3 groups by the graft material used: no graft, autogenous dermis graft, and $AlloDerm^{(R)}$ graft. The healing sites were histologically examined at weeks 4 and 8 after the graft. In another series, critical sized defects with 8-mm diameter were prepared in the right and left iliac bones. The animals were then divided into 5 groups: no graft, grafted with autogenous iliac bone, $AlloDerm^{(R)}$ graft, $AlloDerm^{(R)}$ graft impregnated with rhBMP-2, and $AlloDerm^{(R)}$ graft with rhTGF-${\beta}1$. The healing sites of bone defect were investigated with radiologic densitometry and histological evaluation at weeks 4 and 8 after the graft. Results: In the soft tissue defect, normal healing was seen in the group of no graft. Inflammatory cells and foreign body reactions were observed in the group of autogenous dermis graft, and the migration of fibroblasts and the formation of vessels into the collagen fibers were observed in the group of $AlloDerm^{(R)}$ graft. In the bone defect, the site of bone defect was healed by fibrous tissues in the group of no graft. The marked radiopacity and good regeneration were seen in the group of autogenous bone graft. There remained the traces of $AlloDerm^{(R)}$ with no satisfactory results in the group of $AlloDerm^{(R)}$ graft. In the groups of the $AlloDerm^{(R)}$ graft with rhBMP-2 or rhTGF-${\beta}1$, there were numerous osteoblasts in the boundary of the adjacent bone which was closely approximated to the $AlloDerm^{(R)}$ with regeneration features. However, the fibrous capsule also remained as in the group of $AlloDerm^{(R)}$ graft, which separated the $AlloDerm^{(R)}$ and the adjacent bone. Conclusions: These results suggest that $AlloDerm^{(R)}$ can be useful to substitute the autogenous dermis in the soft tissue defect. However, it may not be useful as a bone graft material or a carrier, since the bone defect was not completely healed by the bony tissue, regardless of the presence of osteogenic factors like rhBMP-2 or rhTGF-${\beta}1$.

저자의 다른 논문

참고문헌 (41)

  1. Gunter JP, Rohrich RJ: Augmentation rhinoplasty: dorsal onlay grafting using shaped autogenous septal cartilage. Plast Reconstr Surg 1990;86:39-45 
  2. Moore WR, Graves SE, Bain GI: Synthetic bone graft substitutes. ANZ J Surg 2001;71:354-361 
  3. Gryskiewicz JM: AlloDerm$^{\circledR}$ lip augmentation. Plast Reconstr Surg 2000;106:953-954 
  4. Schilephake H: Bone growth factors in maxillofacial skeletal reconstruction. Int J Oral Maxillofac Surg 2002;31:469-484 
  5. Fini M, Motta A, Torricelli P, Giavaresi G, Aldini NN, Tschon M, et al: The healing of confined critical size cancellous defects in the presence of silk fibroin hydrogel. Biomaterials 2005;26:3527-3536 
  6. Rennekampff HO, Kiessig V, Griffey S, Greenleaf G, Hansbrough JF: Acellular human dermis promotes cultured keratinocyte engraftment. J Burn Care Rehabil 1997;18:535-544 
  7. Richardson CR, Maynard JG: Acellular dermal graft: a human histologic case report. Int J Periodontics Restorative Dent 2002;22:21-29 
  8. Tsuang YH, Lin FH, Tai HC, Sun JS, Liu HC, Hang YS: Biocompatibility and osteoconductivity of the pyrost bone substitutes. Histol Histopathol 1997;12:19-24 
  9. Zachos TA, Shields KM, Bertone AL: Gene-mediated osteogenic differentiation of stem cells by bone morphogenetic proteins-2 or -6. J Orthop Res 2006;24:1279-1291 
  10. Assoian RK, Komoriya A, Meyers CA, Miller DM, Sporn MB: Transforming growth factors-${\beta}$ in human platelet. J Biol Chem 1983;258:7155-7160 
  11. McKinney L, Hollinger JO: A bone regeneration study: transforming growth factor-${\beta}_1$ and its delivery. J Craniofac Surg 1996;7:36-45 
  12. Chandrasekhar S, Harvey AK: Transforming growth factor-${\beta}$ is a potent inhibitor of IL-1 induced protease activity and cartilage proteoglycan degradation. Biochem Biophy Res Commun 1988;157:1352-1359 
  13. Elshahat A, Inoue N, Marti G, Safe I, Manson P, Vanderkolk C: Guided bone regeneration at the donor site of iliac bone grafts for future use as autogenous grafts. Plast Reconstr Surg 2005;116:1068-1075 
  14. Skillington J, Choy L, Derynck R: Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes. J Cell Biol 2002;159:135-146 
  15. Cheng MH, Brey EM, Allori A, Satterfield WC, Chang DW, Patrick CW Jr, et al: Ovine model for engineering bone segments. Tissue Eng 2005;11:214-225 
  16. Shigenobu K, Kaneda K, Nagai N, Kuboki Y: Localization of bone morphogenetic protein-induced bone and cartilage formation on a new carier: fibrous collagen membrane. Ann Chir Gynaecol Suppl 1993;207:85-90 
  17. Sclafani AP, Romo T 3rd, Jacono AA, McCormick S, Cocker R, Parker A: Evaluation of acellular dermal graft in sheet (AlloDerm$^{\circledR}$) and injectable (micronized AlloDerm$^{\circledR}$) forms for soft tissue augmentation. Clinical observations and histological analysis. Arch Facial Plast Surg 2000;2:130-136 
  18. Jackson IT, Yavuzer R: AlloDerm$^{\circledR}$ for dorsal nasal irregularities. Plast Reconstr Surg 2001;107:553-558 
  19. King GN: The importance of drug delivery to optimize the effects of bone morphogenetic proteins during periodontal regeneration. Curr Pharm Biotechnol 2001;2:131-142 
  20. Park SW, Lee KS, Kim JS: The effects of bone regeneration of the dermal collagen matrix (AlloDerm$^{\circledR}$) graft in the rabbit calvarium. J Korean Soc Plast Reconstr Surg 2005;32:335 
  21. Islam AA, Rasubala L, Yoshikawa H, Shiratsuchi Y, Ohishi M: Healing of fractures in osteoporotic rat mandible shown by the expression of bone morphogenetic protein-2 and tumor necrosis factor-${\alpha}$. Br J Oral Maxillofac Surg 2005;43:383-391 
  22. Yim CJ: Oral and maxillofacial reconstruction with bone allograft. J Kor Acd Maxillofac Plast Reconstr Surg 1997;19:217-231 
  23. Eppley BL: Experimental assessment of the revascularization of acellular human dermis for soft tissue augmentation. Plast Reconstr Surg 2001;107:757-762 
  24. Beck LS, Ammann AJ, Aufdemorte TB, Deguzman L, Xu Y, Lee WP, et al: In vivo induction of bone by recombinant human transforming growth factor ${\beta}_1$. J Bone Miner Res 1991;6:961-968 
  25. Homicz MR, Watson D: Review of injectable materials for soft tissue augmentation. Facial Plast Surg 2004;20:21-29 
  26. Schaberg SJ, Petri WH, Gregory EW, Auclair PL, Jacob E: A comparison of freeze-dried allogeneic and fresh autologous vascularized rib grafts in dog radial discontinuity defects. J Oral Maxillofac Surg 1985;43:932-937 
  27. Menon NG, Rodriguez ED, Byrnes CK, Girotto JA, Goldberg NH, Silverman RP: Revascularization of human acellular dermis in full-thickness abdominal wall reconstruction in the rabbit model. Ann Plast Surg 2003;50:523-527 
  28. Hirata K, Tsukazaki T, Kadowaki A, Furukawa K, Shibata Y, Moriishi T, et al: Transplantation of skin fibroblasts expressing BMP-2 promotes bone repair more effectively than those expressing Runx2. Bone 2003;32:502-512 
  29. Jarcho M: Biomaterial aspects of calcium phosphate. Properties and applications. Dent Clin North Am 1986;30:25-47 
  30. Boyne PJ: Autogenous cancellous bone and marrow transplants. Clin Orthop Relat Res 1970;73:199-209 
  31. Thilander BL, Stenstrom SJ: Bone healing after implantation of some hetero-and alloplastic materials: An experimental study of the guinea pig. Cleft Palate J 1970;7:540-549 
  32. Thomson RC, Mikos AG, Beahm E, Lemon JC, Satterfield WC, Aufdemorte TB, et al: Guided tissue fabrication from periosteum using preformed biodegradable polymer scaffolds. Biomaterials 1999;20:2007-2018 
  33. Chen D, Zhao M, Mundy GR: Bone morphogenetic proteins. Growth Factors 2004;22:233-241 
  34. Onishi T, Ishidou Y, Nagamine T: Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a BMP type II receptor during fracture healing in rats. Bone 1998;22:605-612 
  35. Beck LS, Deguzman L, Lee WP, Xu Y, McFatridge LA, Gillett NA, et al: Rapid publication TGF-${\beta}_1$ induces bone closure of skull defects. J Bone Miner Res 1991;6:1257-1265 
  36. Mulliken JB, Glowacki J: Induced osteogenesis for repair and construction in the craniofacial region. Plast Reconstr Surg 1980;65:553-560 
  37. Chen Y, Luk KD, Cheung KM, Xu R, Lin MC, Lu WW, et al: Gene therapy for new bone formation using adeno-associated viral bone morphogenetic protein-2 vectors. Gene Ther 2003;10:1345-1353 
  38. Conley JJ, Clairmont AA: Dermal fat fascia grafts. Otolaryngol 1978;86:641-649 
  39. Wolf DL: Complication following lip augmentation with Gore-Tex. Plast Reconstr Surg 1995;95:1334-1341 
  40. Novaes AB Jr, Souza SL: Acellular dermal matrix graft as a membrane for guided bone regeneration: a case report. Implant Dent 2001;10:192-196 
  41. Burchardt H: Biology of bone transplantation. Orthop Clin North Am 1987;18:187-196 

이 논문을 인용한 문헌 (0)

  1. 이 논문을 인용한 문헌 없음

원문보기

원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일