본 실험은 2007년 8월에서 9월 동안, 집단 사육되는 토끼에서 피부병을 유발한 주 병원체를 확인하고 역학적인 특성을 조사하기 위해 실시되었다. 총 10개의 농장에서 임상적으로 피부병이 명확한 토끼들을 선별하여 실험에 공시하였다. 40마리의 토끼 피부병변에서 모발 및 피부 조직 520개를 채취하여 진균학적, 세균학적, 기생충학적으로 검사를 실시하였다. 피부사상균, 세균성 피부염 그리고 기생충성 피부염의 발병율은 각각 95%, 92.5% 그리고 7.5%로 나타났다. 진균 배양 결과에서 피부 사상균의 주된 원인체로 Trichophyton mentagrophyte (95%)가 가장 많이 검출되었고, 그 다음으로 Aspergillus s(5%)와 Cryptococcus humilocus (2.5%)가 순차적으로 검출되었다. 세균 배양 결과에서는 토끼의 세균성 피부염을 유발하는 원인체로 Staphylococcus coagulase가 가장 많이 검출되었고, Staphylococcus aureus가 두 번째로 많은 비율을 차지하였다. 이 연구에서는 외부 기생충의 검출은 낮게 나타났으며, Psoroptes cuniculi가 40마리의 토끼 중 3마리에서(7.5%) 검출되었다. 본 실험의 결과는 토끼 피부병 치료와 연구에 관련한 기초 정보를 제공할 것이라 판단된다.
본 실험은 2007년 8월에서 9월 동안, 집단 사육되는 토끼에서 피부병을 유발한 주 병원체를 확인하고 역학적인 특성을 조사하기 위해 실시되었다. 총 10개의 농장에서 임상적으로 피부병이 명확한 토끼들을 선별하여 실험에 공시하였다. 40마리의 토끼 피부병변에서 모발 및 피부 조직 520개를 채취하여 진균학적, 세균학적, 기생충학적으로 검사를 실시하였다. 피부사상균, 세균성 피부염 그리고 기생충성 피부염의 발병율은 각각 95%, 92.5% 그리고 7.5%로 나타났다. 진균 배양 결과에서 피부 사상균의 주된 원인체로 Trichophyton mentagrophyte (95%)가 가장 많이 검출되었고, 그 다음으로 Aspergillus s(5%)와 Cryptococcus humilocus (2.5%)가 순차적으로 검출되었다. 세균 배양 결과에서는 토끼의 세균성 피부염을 유발하는 원인체로 Staphylococcus coagulase가 가장 많이 검출되었고, Staphylococcus aureus가 두 번째로 많은 비율을 차지하였다. 이 연구에서는 외부 기생충의 검출은 낮게 나타났으며, Psoroptes cuniculi가 40마리의 토끼 중 3마리에서(7.5%) 검출되었다. 본 실험의 결과는 토끼 피부병 치료와 연구에 관련한 기초 정보를 제공할 것이라 판단된다.
This study was carried out between August and September 2007 to determine the causative agents and epidemiologic features of rabbit dermatitis in Korea. Rabbits were shipped to the laboratory in the College of Veterinary Medicine from 10 rabbit farms. A total of 520 hair, blood, and skin specimens c...
This study was carried out between August and September 2007 to determine the causative agents and epidemiologic features of rabbit dermatitis in Korea. Rabbits were shipped to the laboratory in the College of Veterinary Medicine from 10 rabbit farms. A total of 520 hair, blood, and skin specimens collected from skin lesions of 40 rabbits with suspected dermatopathy were examined mycologically, bacteriologically, and parasitologically. The positive rates of dermatophytosis, bacterial skin dermatitis, and ectoparasite dermatitis were 95, 92.5, and 7.5%, respectively. The etiologic agents of dermatophytosis were identified as Trichophyton mentagrophyte (95%), non-dermatophytic filamentous fungi such as Aspergillus s(5%), and Cryptococcus humilocus (2.5%). With respect to bacteria-related skin dermatitis, Staphylococcus coagulase negative was the most common etiological agent. Staphylococcus aureus was the second most frequent causative agent. Most of the pathogenic isolates were resistant to tetracycline, and aminoglycosides such as amikacin and gentamicin were the most effective drugs against the pathologic bacteria isolated. Ectoparasites were rarely detected in this study. Only Psoroptes cuniculis was detected in 3 (7.5%) out of the 40 tested rabbits. The role of ectoparasites as a causative agent of dermatitis in rabbits in this study was minimal. Our results provide important information related to rabbit dermatitis treatments and researches.
This study was carried out between August and September 2007 to determine the causative agents and epidemiologic features of rabbit dermatitis in Korea. Rabbits were shipped to the laboratory in the College of Veterinary Medicine from 10 rabbit farms. A total of 520 hair, blood, and skin specimens collected from skin lesions of 40 rabbits with suspected dermatopathy were examined mycologically, bacteriologically, and parasitologically. The positive rates of dermatophytosis, bacterial skin dermatitis, and ectoparasite dermatitis were 95, 92.5, and 7.5%, respectively. The etiologic agents of dermatophytosis were identified as Trichophyton mentagrophyte (95%), non-dermatophytic filamentous fungi such as Aspergillus s(5%), and Cryptococcus humilocus (2.5%). With respect to bacteria-related skin dermatitis, Staphylococcus coagulase negative was the most common etiological agent. Staphylococcus aureus was the second most frequent causative agent. Most of the pathogenic isolates were resistant to tetracycline, and aminoglycosides such as amikacin and gentamicin were the most effective drugs against the pathologic bacteria isolated. Ectoparasites were rarely detected in this study. Only Psoroptes cuniculis was detected in 3 (7.5%) out of the 40 tested rabbits. The role of ectoparasites as a causative agent of dermatitis in rabbits in this study was minimal. Our results provide important information related to rabbit dermatitis treatments and researches.
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문제 정의
However, epidemiologic information is limited with respect to skin problems in rabbits in South Korea. This study was conducted to investigate the outbreak of dermatitis and its causative agents in South Korea. The relevance of farming management and therapeutic treatments were evaluated for 40 rab- bits originating from 10 rabbit farms with different farming conditions in Gyeonggi (n=6)z Chungnam (n=l)z Chungbuk (n=l)z Gangwon (n=l)z and Jeonbuk (n=l) provinces.
제안 방법
Laboratory Standards Institute (CLSI). All bacterial isolates were tested against azithromycin, amikacin, tetracy- cline, cefiiToxim cefazolin, chloramphenicol enrofloxacin, ampicillin, cefotaxime, ciprofloxacin, vancomycin, penicillin Gz erythromycin, clindamycin, amoxicillin-clavulanate/ and trimethoprim-sulfamethoxazole (disks supplied by Oxoid®, Enrofloxacin ENR 5 jig CT0639BTM, Australia, Oxoid® Azithromyxin AZM 15 jig CT0906B, Australia, and BBBL@Z BD SensiDiscTM, United States). Isolates were classified as susceptible, intermediate, or resistant on the basis of the CLSI breakpoints.
대상 데이터
Between August and September 2007/ a total of 40 rabbits suspected of having dermatitis and originating from 5 different provinces in Korea were shipped to the Veterinary College of Konkuk University, Seoul, Korea. Each rabbit was registered according to sex’ breed, agez weight, housing con- ditionz geographic origin, and clinical symptoms related to dermatologic problems (crusting, alopecia, scaling, papules / nodules, or pruritis).
Eight samples fromeach rabbit (4 head, 2 bod- ies, and 2 extremity) were tested. Psoroptes cuniculi was identified in 3 rabbits (Fig.
5%) rabbits of 3 different breeds: New Zealand whites (n=23)z Chinchillas (n=4)z and mixed breeds (n=23) were represented. The 40 rabbits originated from 10 rabbit farms with different farming conditions in Gyeonggi (6/10)z Chungnam (l/10)z Chungbuk (l/10)z Gangwon (l/10)z and Jeonbuk (1/10). Ages ranged from 34 to 60 days.
이론/모형
Antimicrobial susceptibility patterns for all isolates were determined using the Kirby-Bauer disk diffusion method for a range of antimicrobials according to the guidelines of the Clinical Laboratory Standards Institute (CLSI). All bacterial isolates were tested against azithromycin, amikacin, tetracy- cline, cefiiToxim cefazolin, chloramphenicol enrofloxacin, ampicillin, cefotaxime, ciprofloxacin, vancomycin, penicillin Gz erythromycin, clindamycin, amoxicillin-clavulanate/ and trimethoprim-sulfamethoxazole (disks supplied by Oxoid®, Enrofloxacin ENR 5 jig CT0639BTM, Australia, Oxoid® Azithromyxin AZM 15 jig CT0906B, Australia, and BBBL@Z BD SensiDiscTM, United States).
In some cases, crusts were lifted by a blunted scalpel blade, revealing a moist undersurface. The samples were smeared and allowed to air dry in preparation for cytology stain using the Diff-Quick method.
성능/효과
Bacterial pathogens may invade alopecic lesion created by dermatophytosis, and as a result, nodules and pustules may appear. According to the results of the antibiotic sensitivity tests conducted in this study, aminoglycosides such as amikacin and gentamicin were the most effective drugs to treat pathologic bacteria isolated from specimens submitted to the labz followed by enrofloxacin and cefotaxime. Most of the pathogenic isolates were resistant to tetracycline, which has been suggested as the first choice drug in the literature [11, 1245].
and cefotaxime) were 90% effective against coagulase neg- ative Staphylococcus, which represented the highest relative frequency. Six antibiotics (including amoxicillin and clav- ulanate , ampicillin, gentamicin, trimethoprim-sulfamethox- azole, vancomycin, and enrofloxaxin) were 90% effective against S. aureus, which exhibited the second highest rela- tive frequency. Eight antibiotics (including amikacin and cefotaxime) showed excellent effectiveness of 90% against E.
후속연구
signs. Further study is needed to elucidate the details of microbiological culture. For example, localized cultures from the head, body, and extremities or multiple cultures reflecting seasonal variation (spring, summer, autumn, and winter) are required [1-4, 6/74045].
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