$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

알코올성 지방간과 비알코올성 지방간 성인에 있어 혈청 철 표지자, 심장 표지자, 생화학적 표지자의 차이

Difference in Serum Iron, Cardiac, and Biochemical Indices between Alcoholic and Non-alcoholic Fatty Liver

초록

비록 음주가 간손상을 일으키는 지방간의 원인이 되긴 하나 다른 인자들 역시 지방간의 원인이 된다. 우리는 알코올성 지방간(알코올군) 및 비알코올성 지방간 남성(비알코올군)에 있어 철 표지자, 심장표지자, 그리고 생화학적 표지자의 변화와 차이를 연구하였다. 알코올군이 비알코올군 보다 신체지수, 수축기 및 확장기 혈압, 좌우 안압이 유의하게 더 높았다. 또한 혈색소 농도, 적혈구 용적률, 평균 적혈구 혈색소량, 평균 적혈구혈색소 농도, 단구 수 역시 알코올군이 비알코올군 보다 유의하게 더 높았다. 생화학적 지수인 alanine aminotransferase, ${\gamma}$-glutamyltranspeptidase, 총콜레스테롤, 중성지방, 저밀도콜레스테롤, 혈당, 크레아티닌, 요산 등도 알코올군이 비알코올군 보다 유의하게 높았고, 철 지수인 철, 총철결합능, 페리틴 농도 역시 알코올군이 의미있게 더 높았다. 이러한 결과들은 장기적인 알코올 기인성 지방간이 비음주 지방간에 비해 혈청 철농도, 심혈관 표지자, 그리고 생화학적 표지자들을 더 상승시키며, 이는 심혈관 질환 및 대사성 증후군과 같은 성인병에 노출될 가능성이 보다 높을 수 있음을 시사하고 있다.

Abstract

Although alcohol drinking may cause fatty liver to induce hepatocytic injury, other factors lead to it. We designed this study to investigate the differences in serum iron, cardiac, and biochemical indices in men with fatty liver and the difference between alcohol drinkers (Alcohol group) and non-drinkers (Non-alcohol group). The alcohol group had higher body indices than the non-alcohol group. Systolic and diastolic blood pressure (SBP and DBP), and right and left intraocular pressure in the alcohol group were higher than those in the non-alcohol group. Hemoglobin, hematocrit, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, and monocyte counts were higher in the alcohol group than in the non-alcohol group. Alanine aminotransferase, ${\gamma}$-glutamyltranspeptidase, total cholesterol, triglyceride, low-density lipoprotein cholesterol, glucose, creatinine, uric acid, iron, total iron binding capacity, and ferritin levels in the alcohol group were greater than those in the non-alcohol group. The present data reveals that alcohol-induced fatty liver has more elevated level of iron indices than in non-alcohol fatty liver as well as biochemical and cardiac indices, indicating that alcohol- induced fatty liver may cause possibility of adult diseases including cardiovascular disease and metabolic syndrome.

참고문헌 (41)

  1. Abe, H., Y. Kawano, S. Kojima, T. Ashida, M. Kuramochi, H. Matsuoka, and T. Omae. 1994. Biphasic effects of repeated alcohol intake on 24-hour blood pressure in hypertensive patients. Circulation 89, 2626-2633 
  2. Aisen, P., M. Wessling-Resnick, and E. A. Leibold. Iron metabolism. 1999. Curr. Opin. Chem. Biol. 3, 200-206 
  3. Andrews, N. C. 1999. Disorders of iron metabolism. N. Engl. J. Med. 341, 1986-1995 
  4. Bau, P. F. D., C. H. D. Bau, A. A. Naujorks, and G. A. Rosito. 2005. Early and late effects of alcohol ingestion on blood pressure and endothelial function. Alcohol 37, 53-58 
  5. Choudhury, S. R., H. Ueshima, Y. Kita, K. M. Kobayashi, A. Okayama, M. Yamakawa, Y. Hirao, M. Ishikawa, and Y. Miyoshi. 1994. Alcohol intake and serum lipids in a Japanese population. Int. J. Epidemiol. 23, 940-947 
  6. Day, S. M., D. Duquaine, L. V. Mundada, R. G. Menon, B. V. Khan, and S. Rajagopalan. 2003. Chronic iron administration increase vascular oxidative stress and accelerates arterial thrombosis. Circulation 107, 2601-2606 
  7. Duane, P., K .B. Raja, R. J. Simpson, and T. J. Peters. 1992. Intestinal iron absorption in chronic alcoholics. Alcohol & Alcohol 27, 281-289 
  8. Fazio, M., M. Bardelli, B. Fabris, L. Macaluso, F. Fiammengo, F. Vran, M. Bossi, R. Candido, R. Gerloni, and R. Carretta. 2004. Large artery hemodynamics after acute alcohol administration in young, healthy volunteers. Angiology 55, 139-145 
  9. Ganz, T. 2004. Hepcidin in iron metabolism. Curr. Opin. Hematol. 11, 251-254 
  10. Gillum, R. F. 2001. Association of serum ferritin and indices of body fat distribution and obesity in Mexican American men: the third national health and nutrition examination survey. Int. J. Obes. Relat. Metab. Disord. 25, 639-645 
  11. Happel, K. I. and S. Nelson. 2005. Alcohol, immunosuppression and the lung. Proc. Am. Thorac. Soc. 5, 428-432 
  12. Harrison-Findik, D. D., D. Schafer, E. Klein, and N. A. Timchenko, H. Kulaksiz and D. Clemens. 2006. Alcohol metabolism- mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J. Biol. Chem. 281, 22974-22982 
  13. Ioannou, G. N., J. A. Dominitz, N. S. Weiss, P. J. Heagerty, and K. V. Kowdley. 2004. The effect of alcohol consumption on the prevalence of iron overload, iron deficiency, and iron deficiency anemia. Gastroenterology 126, 1293-1301 
  14. Jehn, M., J. M. Clark, and E. Huallar. 2004. Serum ferritin and risk of the metabolic syndrome in U.S. adults. Diabetes Care 27, 2422-2428 
  15. Jiang, R., J. E. Manson, J. B. Meigs, J. Ma, N. Rifai, and F. B. Hu. 2004. Body Iron stores in relation to risk of type 2 diabetes in apparently healthy women. JAMA 291, 711-717 
  16. Kawano, Y., H. Abe, S. Kojima, S. Takishita, and H. Matsuoka. 2004. Effects of repeated alcohol intake on blood pressure and sodium balance in Japanese males with hypertension. Hypertens. Res. 27, 167-172 
  17. Knutson, M. and M. Wessling-Resnick. 2003. Iron metabolism in the reticuloendothelial system. Crit. Rev. Biochem. Mol. Biol. 38, 61-88 
  18. Lee, D. H., D. R. Jacobs, and M. Gross M. 2003. Gamma glutamyltransgerase is a predictor of incident diabetes and hypertension Cardia. Study Clini. Chem. 49, 1358-1366 
  19. Luc, G, J., M. Bard, I. Juhan-vague, J. Ferrieres, A. Evans, and P. Amouyel. 2003. PPIME Study Group, C-reactive protein, interleukin-6 and fibrinogen as predictors of coronary heart disease: the PRIME study. Arterioscler. Thrombo. Avsc. Bia.l. 23, 1255-1261 
  20. McFadden, C. B., C. M. Brensinger, J. A. Berlin, and R. R. Townsed. 2005. Systematic review of the effects of daily alcohol intake on blood pressure. Am. J. Hypertens. 18, 276-286 
  21. Mukamal, K. J., H. Chung, N. S. Jenny, L. H. Kuller, W. T. Longstreth, M. A. Mittleman, G. L. Buke, M. Cushman, N. J. Beauchamp, and D. S. Beauchamp. 2008. Alcohol use and risk of ischemic stroke among oler adults the cardiovascular health study. Alcohol and Ischemic Stroke 10, 1830-1834 
  22. Nicolas, G., L. Viatte, M. Bennoun, C. Beaumont, A. Kahn, and S. Vaulont. 2002. Hepcidin, a new iron regulatory peptide. Blood Cells Mol. Dis. 29, 327-335 
  23. Onat, A., G. Hergenc, D. Duesunoglu, S. Ordu, G. Can, S. Bulur, and H. Yuksel. 2008. Associations of alcohol consumption with blood pressure, lipoproteins, and subclinical inflammation among turks. Alcohol 42, 593-601 
  24. Piperno, A., P. Trombini, M. Gelosa, V. Mauri, V. Pecci V, and A. Vergani. 2002. Increased serum ferritin is common in men with essential hypertension. J. Hypertens. 20, 1513-1518 
  25. Roselle, G., C. L. Mendenhall, and C. J. Grossman. Effects of alcohol on immunity and cancer. In Alcohol, Immunity and Cancer. Yirmiya, R. and A. N. Taylor (eds.), pp. 3-21. RC Press, Boca Raton, FL 
  26. Ryan, T. P. and S. D. Aust. 1992. The role of iron in oxygen- mediated toxicities. Crit. Rev. Toxicol. 22, 119-141 
  27. Tawakol, A., T. Omland, and M. A. Creager. 2004. Direct effect of ethanol on human vascular function. Am. J. Physiol. Heart Circ. Physiol. 286, 2468-2473 
  28. Tsukamoto, H. and S. C. Lu. 2001. Current concepts in the pathogenesis of alcoholic liver injury. F.A.S.E.B. J. 15, 1335-1349 
  29. Tuomainen, T. P., K. Nyyssonene, R. Salonen, A. Tervahauta, H. Korpela, and T. Lakka. 1997. Body iron stores are associated with serum insulin and blood glucose concentrations: population study in 1013 eastern finnish men. Diabetes Care 20, 426-428. 
  30. Valerio, L. G. T. Jr, Parks and D. R. Petersen. 1996. alcohol mediates increases in hepatic and serum nonheme iron stores in a rat model for alcohol-induced liver injury. Alcohol Clin. Exp. Res. 20, 1352-1361 
  31. van Hallest, P. L., D. J. J. van, F. W. Asselbers, R. A. M. van, N. J. Veeger, and M. M. Hennenman. 2003. Correlates of endothelial function and their relationship with inflammation in patients with familial hypercholesterolaemia. Clin. Sci. Lond. 104, 627-632 
  32. Volcik, K. A., C. M. Ballantine, F. D. Fuchs, A. R. Sharrett, and E. Boerwinkle. 2008. Relationship of alcohol consumption and type of alcohol beverage consumed with plasma lipid levels: differences between Whites and African Americans of the ARIC study. Ann. Epidemiol. 18, 101-107 
  33. Wakabayashi, I. 2008. Association of alcohol drinking and cigarette smoking with serum lipid levels in healthy middle- aged men. Alcohol & Alcoholism 43, 274-280 
  34. Wannamethee, G. and A. G. Shaper. 1992. Blood: the relationship with alcohol intake, smoking, and body weight. J. Epidemiol. Comm. 146, 197-202 
  35. Wannamethee, S. G, G. D. O. Lowe, G. Shaper, P. H. Whincup, A. Rumlry, M. Waker, and L. Lennon. 2003. The effects of different alcohol drinks on lipids , insulin and haemostatic and inflammatory markers in older men. Thromb. Haemost. 90, 1080-1087 
  36. Whitfield, J. B., G. Zhu, A. C. Heath, L. W. Powell And, and N. G. Martin. 2001. Effects of alcohol consumption on indices of iron stores and of iron stores on alcohol intake markers. Alcohol. Clin. Exp. Res. 25, 1037-1045 
  37. Williams, M. J. A., R. Poulton, and S. Williams. 2002. Relationship of serum ferritin with cardiovascular risk factors and inflammation in young men and women. Atherosclerosis 165, 179-184 
  38. Wilson, J. G., J. H. Lindquist, S. C. Grambow, E. D. Crook, and J. F. Maher. 2003. Potential role of increased iron stores in diabetes. Am. J. Med. Sci. 325, 332-339 
  39. Winterbourn, C. C. 1995. Toxicity iron and hydrogen peroxide: the Fenton reaction. Toxico. Lett. 82, 969-974 
  40. Wolff, S. P. 1993. Diabetes millitus and free radicals: free radicals, transitional metals and oxidative stress in the aetiology of diabetes millitus and complications. Br. Med. Bull. 49, 642-652 
  41. Zilkens, R. R., V. Burke, J. M. Hodgson, A. Barden, and L. J. Beilin. 2005. Red wine and beer elevate blood pressure in normotensive men. Hypertension 45, 874-879 

이 논문을 인용한 문헌 (1)

  1. 이민수, 김명철, 안청좌 2014. "들숨근 훈련과 테이핑 동시적용이 호흡의 근력, 지구력, 폐기능 향상에 미치는 영향" Journal of the Korean Society of Integrative Medicine = 대한통합의학회지, 2(3): 65~73 

원문보기

원문 PDF 다운로드

  • ScienceON :
  • KCI :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

이 논문 조회수 및 차트

  • 상단의 제목을 클릭 시 조회수 및 차트가 조회됩니다.

DOI 인용 스타일

"" 핵심어 질의응답