[논문]한국에서 개 유선종양과 피부종양의 발생현황

김영훈; 안나경; 노인순; 윤병일; 한정희

한국에서 개 유선종양과 피부종양의 발생현황
Retrospective Investigation of Canine Skin and Mammary Tumors in Korea 원문보기

Journal of veterinary clinics = 한국임상수의학회지, v.26 no.6 = no.71, 2009년, pp.556 - 562

김영훈 (강원대학교) , 안나경 (강원대학교) , 노인순 (국립수의과학검역원) , 윤병일 (강원대학교) , 한정희 (강원대학교)

초록
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피부와 유선 종양은 개에서 매우 빈번히 발생하는 종양으로, 종양 발생의 위험은 나이가 증가함에 따라 종양의 발생률은 증가하며, 발병률과 발병부위의 분포는 종양의 종류마다 다르다. 피부와 유선종양의 발생은 공기오염, 식생활 등 환경의 변화와도 관련이 있어 이들 종양들의 발생양상은 그 사회의 환경을 반영할 수 있어 시대와 지역에 따라 다양하게 다르게 나타날 수 있다. 따라서, 그 동안의 많은 보고들에도 불구하고, 피부와 유선종양발생에 대한 자료들은 종양에 대한 수의임상학적 진단과 치료를 위한 중요한 정보를 제공한다. 본 연구에서는 2005년 1월 1일부터 2006년 12월 31일까지 수의과학검역원과 강원대학교에 의뢰된 128증례의 개 피부종양과 240증례의 개 유선종양을 Goldschmidt와 Misdorp의 형태학적 기준에 의해 조직병리학적으로 진단하여, 종별, 성별 및 부위별로 각각 분류하여 국내에서 이들 종양의 발생양상을 체계적으로 분석하였다. 피부종양에서는 피부상피세포종양, 샘종양 및 간질종양이 각각 14.1%, 41.4%와 44.5%였다. Cutaneous histiocytoma가 피부종양에서 가장 빈번하게 관찰되어 전체 피부종양의 25.0%를 차지하였으며, 기름샘종 (sebaceous gland adenoma; 15.6%), 기저세포종(basal cell tumor; 8.6%), 항문둘레샘종 (perianal gland adenoma; 6.3%)와 지방종 (lipoma; 6.3%)순으로 높았다. 그 외에 비만세포종, 모낭세포종과 중층편평상피암 등이 관찰되었다. 이러한 피부종양들은 품종, 성과 나이 또는 부위에 따라 유사하거나 다른 양상을 나타내었다. 유선종양의 경우 양성과 악성이 201/240, 39/240으로 양성발생률이 현저히 높았으며, 양성혼합종 (benign mixed tumor)이 검사한 품종 모두에서 가장 높은 발생률 (35.0%)을 나타내었다. Complex adenoma는 Maltese와 Poodle에서 특히 높았으며, 악성종양에서는 simple carcinoma와 complex carcinoma가 각각 6.7%로, 악성 중 41.0%를 차지하여 가장 높은 발생률을 나타내었다. 본 연구결과는 최근 우리나라에서 여러 품종의 반려견에서 발생한 피부와 유선종양의 발생양상을 조직병리학적으로 진단 분석한 것으로, 임상수의사들이 지속적으로 증가추세에 있는 개의 피부와 유선종양을 진단하고 치료하는데 유용하게 활용될 수 있기를 기대한다.

Abstract ▼ AI-Helper

Skin tumors and mammary gland tumors have been shown to be the most common neoplasia in most of the strains of dogs. The risk for tumor development increases significantly with age and the prevalence and distribution are various according to individual tumors. The aim of this study is to classify histopathologically the skin and mammary gland tumors for recent two years, 2005 and 2006. A total of 128 skin and 240 mammary gland samples of dogs were selected that were submitted to National Veterinary Research and Quarantine Service and Kangwon National University from January 1, 2005 to December 31, 2006. The excised tissue were fixed in 10 percent neutral buffered formalin and processed routinely to paraffin wax. Sections were cut at $3{\mu}m$, stained with haematoxylin and eosin. The slides were examined based on the morphological criteria of M. H. Goldschmidt and W. Misdorp under a light microscope. The age of the dogs ranged from 1 to 19 years with a median of 8.7 years. The mean age of the skin and mammary gland tumors was 7.4 and 9.3 years. 47 (12.8%) were males and 259 (70.4%) were female with a male to female ratio of 0.18. Yorkshire terrier and maltese were more susceptible breeds, accounting for 44.3% of skin and mammary gland tumors. In skin tumors, epithelial, adnexal, and mesenchymal origin tumors were 18 (14.1%), 53 (41.4%), and 57 cases (44.5%), repectively. Among the epithelial, adenexal, and mesenchymal origin tumors, basal cell tumor (8.6%), sebaceous adenoma (15.6%), and histiocytoma (25.0%) were predominant in the incidence rate, respectively. In case of mammary gland tumors, 201 (83.8%) were benign and 39 (16.3%) were malignant with a benign to malignant ratio of 5.15. The most frequent mammary gland tumor was benign mixed tumor (35.0%) followed by mammary adenoma-complex type (31.7%).

주제어

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문제 정의

Basal cell tumor followed the sebaceous gland adenoma in the frequency in the skin tumors examined in this study. This tumor was the most common in the epidermal cell skin tumors in this study, which has been usually found in the previous studies (1,2,8,12,18,20,23).

대상 데이터

For the study, a total of 128 skin and 240 mammary gland samples were respectively selected that had been submitted to National Veterinary Research and Quarantine Service and Kangwon National University from January 1, 2005 to December 31, 2006. The examined samples consisted of 47 male and 259 female cases and the age range of the dogs was from 1 year to 19 years.
For the study, a total of 128 skin and 240 mammary gland samples were respectively selected that had been submitted to National Veterinary Research and Quarantine Service and Kangwon National University from January 1, 2005 to December 31, 2006. The examined samples consisted of 47 male and 259 female cases and the age range of the dogs was from 1 year to 19 years. Dividing the cases based on age, < 5 years old, 6 to 10 years old, 11 to 15 years old, and above 16 years were 51, 39, 34, and 2 cases for skin tumors and 29, 129, 73 and 5 cases for mammary tumors, respectively (Table 1).

성능/효과

5%), respectively. Among all of the skin tumors, cutaneous histiocytoma was found the most frequent as 32 cases (25.0%), followed by sebaceous gland adenoma (20 cases, 15.6%), basal cell tumor (11 cases, 8.6%), perianal gland adenoma and lipoma (8 cases for each, 6.3%), fibroma (7 cases, 5.0%), pilomatricoma (6 cases, 4.7%), mast cell tumor and trichoblastoma (5 cases for each, 3.9%) and squamous cell carcinoma and papilloma (3 cases for each, 2.3%) (Table 2).
5 years. As other benign tumors, adenoma including complex and simple type, duct papilloma, and fibroadenoma respectively accounted for 31.6% (76 cases), 13.8% (38 cases), 0.4% (1 case), and 0.8% (2 cases) of mammary tumors (Table 5). In Maltese and Poodle breeds, adenoma, in particular complex type, was more common than benign mixed tumor (Table 6).
In Maltese and Poodle breeds, adenoma, in particular complex type, was more common than benign mixed tumor (Table 6). In malignant mammary tumors, carcinomas of simple and complex type were evident in 16 cases out of 39 malignant tumors for each, accounting for 6.7% of total number of mammary gland tumors and 41.0% of malignant. Carcinosarcoma and mucinous carcinoma were respectively diagnosed in 6 cases and 1 case, accounting for 2.
Yorkshire terrier (30 skin tumors and 54 mammary tumors), Maltese (13 skin tumors and 65 mammary tumors), Shihtzu (26 skin tumors and 24 mammary tumors), Poodle (9 skin tumors and 40 mammary tumors), Cocker spaniel (7 skin tumors and mammary tumors), Schanuzer (9 skin tumors and 3 mammary tumors), Mixed (20 skin tumors and 27 mammary tumors) and other strains (14 skin tumors and 20 mammary tumors) were applied for the study. In the tumors examined, 44 and 56 cases of skin tumors and 3 and 203 cases of mammary tumors were respectively from male and female dogs and other 28 and 34 cases of skin and mammary tumors were unknown in gender.
In particular, sebaceous gland adenoma was found distinguishably high in female of this breed. Perianal gland tumor was found in 8 cases (6.3% in skin tumors), accounting for 15.1% of total number of adnexal skin tumors (Table 2). This tumor was generally developed in the relatively old male dogs; its incidence in male was 2.

참고문헌 (23)

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