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NTIS 바로가기Korean journal of microbiology = 미생물학회지, v.45 no.2, 2009년, pp.185 - 192
Chungkookjang fermenting Bacillus subtilis 028-1 strain suppressed the growth of Staphylococcus sp. LS2, Saccharomyces cerevisiae, and Candida albicans. B. subtilis 028-1 strain produced antibiotic effectively in the medium of 2% soybean meal and 1% maltose as a disaccharide, when the shaking was co...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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Bacillus 속 세균의 정체기에는 무엇이 유도되는가? | Bacillus 속 세균을 배양하면 한 가지 이상의 필수영양소 성분이 고갈되고, 이는 균 생장을 정체기로 들어가게 한다. 이 시기에 포자 형성, competence화, 세포 외부로의 분해효소 생산, 그리고 항생물질 생산에 관련된 유전자 무리들의 발현이 유도된다. 이러한 다양한 반응은 영양 stress에 대한 생존 전략이며 항생물질의 생산은 생산균주로 하여금 제한된 영양분이 존재하는 환경에서의 경쟁력을 강화하기 위함으로 보여진다. | |
Bacillus subtilis가 생산하는 항생물질의 주종인 peptide의 특징은 무엇인가? | Bacillus subtilis가 생산하는 항생물질의 주종인 peptide들은 구조적으로 매우 단단하며 소수성이고 환상구조로 되어있으며, D형 아미노산을 포함하고 있어서 peptidase나 protease에 저항성을 나타낸다. | |
ribosome에 의하지 않는 lipopeptide 항생물질들은 어떤 구조를 가지는가? | 또한 ribosome에 의하지 않는 lipopeptide 항생물질들은 peptide에 덧붙여서 β-hydroxyl 또는 β-amino fatty acid가 모여진 구조를 가지며(17), non-ribosomal peptide synthetase (NRPS)라고 불리는 큰 효소에 의해 독특하게 합성되는데, 이들이 세포 내의 특정 목표에 정확하게 작용하는 것이 알려지면서 새로운 약품의 제조에 기대를 모으고 있다(41). |
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