Effects of Dietary Supplementation with a Compound Composed of Caffeine, Capsaicin, Sesamine, L-Carnitine, Banaba and Lotus on Human Autonomic Nervous System Activity and Lipid Oxidation원문보기
This study was conducted to determine if supplementation with a compound composed of caffeine (50 mg), capsaicin (75 mg), sesamine (30 mg), L-carnitine (300 mg), banaba (50 mg) and lotus (10 mg) enhanced human autonomic nervous activities (ANS) associated with thermogenic sympathetic activity and fa...
This study was conducted to determine if supplementation with a compound composed of caffeine (50 mg), capsaicin (75 mg), sesamine (30 mg), L-carnitine (300 mg), banaba (50 mg) and lotus (10 mg) enhanced human autonomic nervous activities (ANS) associated with thermogenic sympathetic activity and fat utilization. Ten healthy college males (21.2$\pm$1.0 yr) volunteered for this experiment. Autonomic nervous activities associated with energy metabolism were examined at 30 min intervals for a total of 120-min while at rest and every 5-min during exercise at 50% of the ventilation threshold before and after intake of the compound or placebo with 100 ml of water for 10 days. In addition, heart rate variability power spectral analysis was used to assess human autonomic nervous activities. The results indicated that there were no significant differences in heart rate during rest and exercise among trials. Furthermore, the autonomic nervous activity tended to increase after 10-days of consumption of the test compounds during the experimental period, but the differences did not reach statistical significance. However, before and after the compound test trial there was a significantly higher respiratory gas exchange ratio (rest 0: 0.83$\pm$0.01 vs. rest 3: 0.89$\pm$0.02, p<0.05), carbohydrate oxidation (CHO) rate (rest 0: 44.57$\pm$5.83 vs. rest 2: 63.86$\pm$5.91%, p<0.05) and a lower fat oxidation rate (rest 0: 55.43$\pm$5.83 vs. rest 2: 36.14$\pm$5.91%, p<0.05. In conclusion, the results of the present study suggested that the compound composed of caffeine, capsaicin, sesamine, L-carnitine, banaba and lotus components that was evaluated in this study did not induce a significant increase in human autonomic nervous activities or lipolysis, even though the individual components have been reported to induce increased fat oxidation.
This study was conducted to determine if supplementation with a compound composed of caffeine (50 mg), capsaicin (75 mg), sesamine (30 mg), L-carnitine (300 mg), banaba (50 mg) and lotus (10 mg) enhanced human autonomic nervous activities (ANS) associated with thermogenic sympathetic activity and fat utilization. Ten healthy college males (21.2$\pm$1.0 yr) volunteered for this experiment. Autonomic nervous activities associated with energy metabolism were examined at 30 min intervals for a total of 120-min while at rest and every 5-min during exercise at 50% of the ventilation threshold before and after intake of the compound or placebo with 100 ml of water for 10 days. In addition, heart rate variability power spectral analysis was used to assess human autonomic nervous activities. The results indicated that there were no significant differences in heart rate during rest and exercise among trials. Furthermore, the autonomic nervous activity tended to increase after 10-days of consumption of the test compounds during the experimental period, but the differences did not reach statistical significance. However, before and after the compound test trial there was a significantly higher respiratory gas exchange ratio (rest 0: 0.83$\pm$0.01 vs. rest 3: 0.89$\pm$0.02, p<0.05), carbohydrate oxidation (CHO) rate (rest 0: 44.57$\pm$5.83 vs. rest 2: 63.86$\pm$5.91%, p<0.05) and a lower fat oxidation rate (rest 0: 55.43$\pm$5.83 vs. rest 2: 36.14$\pm$5.91%, p<0.05. In conclusion, the results of the present study suggested that the compound composed of caffeine, capsaicin, sesamine, L-carnitine, banaba and lotus components that was evaluated in this study did not induce a significant increase in human autonomic nervous activities or lipolysis, even though the individual components have been reported to induce increased fat oxidation.
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제안 방법
2. Changes in VLF of ANS in healthy males after consumption of the test tablets at rest for a total of 120-min and for 5-min during exercise as determined using heart rate variability power spectral analysis. There were no significant differences among test trials.
3. Changes in the LF of ANS in healthy males after consumption of test tablets at rest for 120-min and for 5-min during exercise as determined using heart rate variability power spectral analysis. There were no significant differences among test trials.
In this study, we evaluated the effects of a combination of caffeine, capsaicin, sesamine, L-carnitine, banaba and lotus components on ANS activity and energy metabolism in healthy males during resting and exercise periods. Specifically, we evaluated the effects of test tablets containing the aforementioned compounds to determine if they induced an increase in cardiac ANS activity associated with energy metabolism that led to fat oxidation.
Subjects came to the laboratory at 9:00 am after eating a traditional Japanese breakfast that consisted of 70% carbohydrates, 20% protein and 10% fat at least 2 hr before arriving at the laboratory on four different occasions. The ANS activity and energy metabolism were measured as baseline data prior to ingestion of the compound which consisted of caffeine (50 mg), capsaicin (75 mg), sesamine (30 mg), L-carnitine (300 mg), banaba (50 mg) and lotus (10 mg), or placebo.
Therefore, in this study, HRV power spectral analysis was used to evaluate energy metabolism and ANS activity, particularly thermogenic-sympathetic function in response to treatment with tablets that contained of a combination of components that could be taken as a convenient nutritional supplement.
To evaluate the ANS activity, we analyzed the VLF, LF, HI, and total power by integrating the spectra of each respective bandwidth. The mean heart rate of each 256-s segment was also calculated with the standard error.
대상 데이터
Ten healthy male [mean (SE) 21.2 (1.0) yr, 172.8 (2.4) cm, 62.2 (2.0) kg and % fat 14.6 (1.0) (estimated by bio-impedance method)] students from K University volunteered for this experiment. All experimental procedures were explained in detail to each subject, who then signed a statement of informed consent.
데이터처리
Statistical differences between treatments were assessed using two-way analysis of variance (ANOVA) with repeated measurements for time, treatment and time×treatment as well as one-way ANOVA to evaluate the effects of the test tablet after 10 days.
성능/효과
However, the test tablets administered in the present study did not enhance the RQ and substrate oxidation. Although each individual component of the test tablets has been reported the induce an increase in dietary fat oxidation, the results of the present study showed that tablets containing a mixture of these compounds had no effect on metabolism. Further research should be conducted to provide a more in-depth comprehension of this mechanism.
In conclusion, we demonstrated that oral administration of the compound for 10-days did not induce any changes in the ANS activity and lipolysis activation in human subjects. It should be considered the consumption of the compound dietary supplementations for weight control and/or energy homeostasis.
The results indicate that the RQ values increased significantly before and after consumption of the compound [rest 0, 0.83 (0.38) vs. rest 2, 0.88 (0.38); rest 0, 0.83 (0.38) vs. rest 3, 0.88 (0.43), p<0.05].
Nevertheless, to the best of our knowledge no studies have been conducted to date to evaluate the effects of compound administered to subjects in the present study in humans. Therefore, this study provides useful results, even though there were no significant differences observed in the cardiac ANS activity and substrate oxidation among groups.
후속연구
Although each individual component of the test tablets has been reported the induce an increase in dietary fat oxidation, the results of the present study showed that tablets containing a mixture of these compounds had no effect on metabolism. Further research should be conducted to provide a more in-depth comprehension of this mechanism.
It is important to note that the results of this study were derived from a small number of subjects using non-invasive measures; therefore, interpretation of the results must be carefully considered until a larger scale study confirms the present findings. Nevertheless, to the best of our knowledge no studies have been conducted to date to evaluate the effects of compound administered to subjects in the present study in humans.
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