To control degradation rate of biodegradable poly(lactide)s (PLA), the stereochemical PLAs with different ratios of d-lactide and l-lactide units were synthesized by the ring open polymerization and the their degradation kinetics were measured by a Langmuir film balance. The alkaline (pH=11) degradation of poly(l-lactide) (l-PLA) monolayer showed the faster rate at a surface pressure of 4 mN/m in the ranges from to 0 to 7 mN/m. However, the enzymatic degradation of l-PLA with Proteinase K did not occur until 4 mN/m. Above a constant surface pressure of 4 mN/m, the degradation rate was increased with a constant surface pressure. These behaviors might be attributed to the difference in the contacted area with degradation medium: alkaline ions need small contact area with l-PLA while enzymes require much bigger one to be activated due to different medium sizes. The stereochmical PLA monolayers showed that the alkaline degradation was increased with their optical impurities while the enzymatic one was inversed. These results could be explained by the decrease of crystallinity with the optical impurity and the inactivity of enzyme to d-LA unit.
Ryou J. H., Ha C. S., Kim J. W., Lee W. K., 2003, Control of Enzymatic Degradation of Microbial Polyesters by Plasma Modification, Macromol. Biosci., 3, 44-50.
Lee W. K., Ryou J. H., Ha C. S., 2003, Retardation of enzymatic degradation of microbial polyesters ususing surface chemistry: effect of addition of non-degradable polymers, Surf. Sci., 542, 235-243.
Lee W. K., Norwak R., Gardella J. A., 2002, The Hydrolytic Degradation of Polyester Blend Monolayers at the Air/liquid Interface: Effects of a Slowly Degrading Component, Langmuir, 18, 2309-2312
민성기, 문명준, 이원기, 2006, 모델 시스템을 이용한 Poly(1-lactide)의 분해거동, 한국환경과학회지, 15(2), 177-184
Kikkawa Y., Yamashita K., Hiraishi T., Kanesato M., Doi Y., 2005, Dynamic Adsorption Behavior of Poly(3-hydroxybutyrate) Depolymerase onto polyester Surface Investigated by QCM and AFM, Biomacromolecules, 6(4), 2084-2090.
Reeve M. S., McCarthy S. P., Downey M. J., Gross R. A., 1994, Polylactide stereochemistry: effect on enzymatic degradability, Macromolecules, 27, 825-831.
Wiggins J, S., Hassan M. K., Mauritz K. A., Storey R. F., 2006, Hydrolytic degradation of poly(d,1-lactide) as a function of end group: Carboxylic acid vs. hydroxyl, Polymer, 47(6), 1960-1969
Hocking P. J., Marchessault R. H., Timmins M. R., Lenz R Z., Fuller R C., 1996, Enzymatic Degradation of Single Crystals of Bacterial and Synthetic Poly($\beta$-hydroxybutyrate), Macromolecules, 29, 2472-2478
이 논문을 인용한 문헌 (4)
Jang, Seong-Ho ; Park, Sang-Bo ; Lee, Won-Ki 2010. "Control of Enzymatic Degradability of Biodegradable Polylactide by Blending with Non-degradable Polymers" 한국환경과학회지 = Journal of the environmental sciences, 19(9): 1161~1167