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논문 상세정보

Abstract

Objective: This study was to investigate the anti-tumor effect, safety, safety, mechanism and metabolizing enzyme of Agrimonia pilosa LEDEB (APL) in female C57B/L mouse tumor (in vivo). Method: First, to evaluate the antitumor activity of APL, we divided the mice into four groups: normal, control, APL50 (50mg/kg), and APL100 (100mg/kg). LLC-obtained American Type Culture Collection was used. LLC had been inoculated to induce tumors. To measure the anti-tumor effect of APL, we calibrated tumor size and weight. To analyze the mechanism of anti-tumor in APL, we used western blotting and to observe metabolizing enzyme in APL we used to real-time PCR. Result: APL50 and APL100 significantly inhibited tumor growth from 12 days after medicine injected. APL did not induce caspase-dependent apoptosis in LLC-bearing mouse tumor. In APL100, it decreased 41% and 71% in CYP2D22 and CYP3A11, respectively. Conclusion: These results suggest that APL has some anti-tumor effects in female C57B/L mouse tumor. APL should be used carefully with other drugs related with CYP2D22 and CYP3A11.

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이 논문을 인용한 문헌 (1)

  1. Ryu, Hee Kyoung ; Goo, Bon Hyuk ; Suk, Kyung Hwan ; Lee, Ju Hyeon ; Ryu, Soo Hyeong ; Lee, Su Yeon ; Kim, Min Jeong ; Park, Yeon Cheol ; Baek, Yong Hyeon ; Park, Dong Suk ; Seo, Byung Kwan 2014. "The Current Research Methodology of Pharmacopucture for the Treatment of Animal Cancer Models in Korea" The acupuncture = 대한침구의학회지, 31(4): 81~97 

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