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논문 상세정보

복분자 딸기(Rubus coreanum) 에탄올 및 열수추출물의 항돌연변이 활성과 암세포 성장 억제 효과

Antimutagenic and Cytotoxic Activity of Ethanol and Water Extracts from Rubus coreanum

Abstract

The antimutagenic and cytotoxic activities of ethanol and water extracts from Rubus coreanum were investigated in this study. Their antimutagenic activities were measured by the Ames test and their cytotoxic activities were evaluated by the growth inhibition of cancer cells via the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) assay and the sulforhodamine B (SRB) assay. In the results, the inhibition rates of the ethanol and water extracts toward mutagenicity induced by 4-NQO were 95.0% and 93.6% at 5 mg/plate, respectively, while their inhibition rates against mutagenicity induced by sodium azide were 27.2% and 40.8%, respectively. According to MTT assay, the cytotoxicity values of the ethanol extract against Hep3B and HeLa cells were 67.2% and 68.5%, respectively, and the values for the water extract were 65.8% and 66.4%, respectively. In the SRB assay, the ethanol and water extracts inhibited over 60% of cancer cell growth. In conclusion, both the ethanol and water extracts of Rubus coreanum offer potentially good antimutagenic and anticancer effects.

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이 논문을 인용한 문헌 (9)

  1. Hong, Seul-Gi ; Jeong, Dong-Myong ; Kim, Ki-Young ; Hwang, Eun-Hee 2010. "The Composition of the Root of Ixeris dentata var. albiflora Nakai. and Cell Viability and DPPH Radical Scavenging Activities of its Extract" 韓國營養學會誌 = The Korean journal of nutrition., 43(2): 105~113 
  2. Lee, Kyoung-In ; Kim, Su-Min ; Kim, Sun-Min ; Pyo, Byoung-Sik 2011. "Comparison of Fatty Acids and Antibacterial Activity against Pathogen of Acne in Different Parts of Ripened Black Raspberry (Rubus coreanus Miquel)" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 40(3): 466~469 
  3. Seo, Yong-Chang ; Choi, Woon-Yong ; Kim, Ji-Seon ; Cho, Jeong-Sub ; Kim, Young-Ock ; Kim, Jin-Chul ; Lee, Hyeon-Yong 2011. "Enhancement of Anticancer Activities from Lithospermum erythrorhizon Extracts by Ultra High Pressure Process" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 19(2): 103~110 
  4. Kim, Se-Ryoung ; Won, Ji-Hye ; Kim, Mee-Ra 2011. "Antimicrobial Activity against Food Hazardous Microorganisms and Antimutagenicity against Salmonella serotype Typhimurium TA100 of an Ethanol Extract from Sanguisorba officinalis L." 한국식품조리과학회지 = Korean Journal of Food & Cookery Science, 27(4): 17~26 
  5. Choi, Mi-Ran ; Lee, Min-Young ; Hong, Ji-Eun ; Lee, Jae-Yong ; Chun, Jang-Woo ; Kim, Tae-Hwan ; Shin, Hyun-Kyung ; Kim, Eun-Ji 2012. "The Aqueous Extract of Rubus coreanus Miquel Improves Scopolamine-Induced Memory Impairment in ICR Mice" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 41(2): 192~196 
  6. Jeon, Yeon-Hee ; Sun, Xiaoqing ; Kim, Mee-Ra 2012. "Antimicrobial Activity of the Ethanol Extract from Rubus coreanum against Microorganisms Related with Foodborne Illness" 한국식품조리과학회지 = Korean Journal of Food & Cookery Science, 28(1): 9~15 
  7. Choi, Mi-Ran ; Lee, Min-Young ; Kim, Jeong-Eun ; Hong, Ji-Eun ; Jang, Kuen-Hye ; Lee, Jae-Yong ; Chun, Jang-Woo ; Kim, Tae-Hwan ; Shin, Hyun-Kyung ; Kim, Eun-Ji 2012. "Rubus coreanus Miquel Improves on Impairment of Memory in Senescence-Accelerated Mouse (SAM)" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 41(9): 1253~1258 
  8. Lee, Gee-Dong 2013. "Monitoring on preparation properties of Bokbunja (Rubus coreanus Miquel) granule" 한국식품저장유통학회지 = Korean journal of food preservation, 20(4): 532~538 
  9. Song, You-Na ; Lee, Heon-Ok ; Noh, Geon-Min ; Kim, Haeng-ran ; Choe, Jeong-Sook ; Om, Ae-Son 2015. "Review on Anti-Cancer and Anti-Imflammatory Activity from Rubus coreanus Miquel" Culinary science & hospitality research = 한국조리학회지, 21(5): 160~170 

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