$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

고련피 추출물의 항암활성

Anti-cancer Activities of Extract from the Bark of Melia azedarach L. var. japonica Makino

Abstract

In the present study, the anti-cancer activity of 80% ethanol extracts from 120 kinds of medicinal herbs and native plants were investigated. Among them, the barks of Melia azedarach L. var. japonica Makino showed the highest cytotoxicity in HCT-15 human colon cancer cell. With this result, we carried out hollow fiber (HF) assay and anti-metastasis study to confirm the anti-cancer effects of M. azedarach var. japonica. In MTT assay, M. azedarach var. japonica.inhibited the proliferation of HCT-15 cells in dose-dependent manner. HF assay was carried out using A549 human adenocarcinoma cell, HCT-15 and SK-Hep1 human liver cancer cell via intraperitoneal (IP) and subcutaneous (SC) site. As a results, SK-Hep1 implanted in IP site showed the highest cytotoxicity. The result from metastatic model using B16/BL6 mouse corresponded to that of HF assay. These results suggest that the ethanol extract from M. azedarach var. japonica. might have a potent anti-cancer activity and advanced study is needed for the development of novel natural anti-cancer drug.

저자의 다른 논문

참고문헌 (26)

  1. Baguley, B.C. and Nash, R. 1981. Antitumour activity of substituted 9-anilinoacridines-comparison of in vivo and in vitro testing systems. Eur. J. Cancer 17:671-679 
  2. Boyd, M.R. 1989. Status of the NCI preclinical antitumor drug discovery screen. Principles and Practice of Oncology 3:1-12 
  3. Bridges, E.M., Bibby, M.C. and Burchill, S.A. 2006. The hollow fiber assay for drug responsiveness in the ewing's sarcoma family of tumors. J. Pediatr. 149:103-111 
  4. Casciari, J.J., Hollingshead, M.G., Alley, M.C., Mayo, J.G. and Malspeis, L. 1994. Growth and chemotherapeutic response of cells in a hollow-fiber in vitro solid tumor model. J. Natl. Cancer Inst. 86:1846-1852 
  5. Cespedes, C.L., Alarcon, J., Aranda, E., Becerra, J. and Silva, M. 2001. Insect growth regulator and insecticidal activity of beta-dihydroagarofurans from Maytenus spp. (Celastraceae). Z. Naturforsch C. 56:603-613 
  6. Cha, S.M. 1977. Potential anticancer medicinal plants. A statistical evaluation of their frequencies of appearance in oriental medicine formularies. Kor. J. Pharmacogn. 8:1-15 
  7. Denizot, F. and Lang, R. 1986. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J. Immunol. Methods 89:271-277 
  8. Geran, R.I., Greenberg, N.H., Macdonald, M.M. and Abbott, B.J. 1977. Modified protocol for the testing of new synthetics in the L1210 lymphoid leukemia murine model in the DR&D program, DCT, NCI. Natl. Cancer Inst. Monogr. 45:151-153 
  9. Holbeck, S.L. 2004. Update on NCI in vitro drug screen utilities. Eur. J. Cancer 40:785-793 
  10. Hollingshead, M.C., Alley, M.C., Camalier, R.F., Abbot, B.J. and Mayo, J.G. 1995. In vivo cultivation of tumor cells in hollow fibers. Life Sci. 57:131-141 
  11. Hong, M.H. 1972. Statistical studies on the formularies of oriental medicine(1) prescription frequency and their origin distribution of herb drugs. Kor. J. Pharmacogn. 3:57-64 
  12. Hwang, W.I., Lee, S.D. and Oh, S.K. 1982. A study on the pharmacological activities of Korean medicinal herbs mamly on the antitumor activities (in Korean). Kor. Biochem. J. 15:205-219 
  13. Hwang, W.I. and Oh, S.K. 1984. Effects of petroleum ether extract of ginseng root on same enzyme activity in human colon cancer cells. Kor. J. Ginseng Sci. 8:153-166 
  14. Itokawa, H., Qiao, Z.S., Hirobe, C. and Takeya, K. 1995. Cytotoxic limonoids and tetranortriterpenoids from Melia azedarach. Chem. Pharm. Bull. 43:1171-1175 
  15. Keshri, G., Lakshmi, V. and Singh, M.M. 2003. Pregnancy interceptive activity of Melia azedarach Linn. in adult female Sprague-Dawley rats. Contraception 68:303-306 
  16. Khan, M.R., Kihara, M. and Omoloso, A.D. 2001. Antimicrobial activity of Horsfieldia helwigii and Melia azedarach. Fitoterapia 72:423-427 
  17. Kwon, H.C., Lee, B.G., Kim, S.H., Jung, C.M. and Hong, S.Y. 1999. Inducible nitric oxide synthase inhibitors from Melia azedarach var. japonica. Arch. Pharm. Res. 22:410-413 
  18. Lee, B.G., Kim, S.H., Zee, O.P., Lee, K.R. and Lee, H.Y. 2000. Suppression of inducible nitric oxide synthase expression in RAW 264. 7 macrophages by two beta-carboline alkaloids extracted from Melia azedarach. Eur. J. Pharmacol. 406:301-309 
  19. Lee, J.Y., Hwang, W.I. and Lim, S.T. 1998. Effects of Platycodon grandiflorum DC. extract on the growth of cancer cell lines. Kor. J. Food Sci. Technol. 30:13-21 
  20. Miyazaki, T. and Nishijima, M. 1981. Studies on fungal polysaccharides. XXVII. Structural examination of a water-soluble, antitumor polysaccharide of Ganoderma lucidum. Chem. Pharm. Bull. 29:3611-3616 
  21. Ofulla, A.V., Chege, G.M., Rukunga, G.M., Kiarie, F.K. and Githure, J.I. 1995. In vitro antimalarial activity of extracts of Albizia gummifera, Aspilia mossambicensis, Melia azedarach and Azadirachta indica against Plasmodium falciparum. Afr. J. Health Sci. 2:309-311 
  22. Plowman, J., Camalier, R., Alley, M., Sausville, E. and Schepartz, S. 1999. US NCI testing procedures. In: Fiebig H-H, Burger AM, editors. Contributions in oncology:relevance of tumour models for anticancer drug development. Basel: Karger pp. 121-135 
  23. Son, H.S. and Hwang, W.I. 1990. A study on the cytotoxic activity of garlic (Allium sativum) extract against cancer cells (in Korean). Kor. J. Nutrition 23:135-147 
  24. Takeya, K., Quio, Z.S., Hirobe, C. and Itokawa, H. 1996a. Cytotoxic trichilin-type limonoids from Melia azedarach. Bioorg. Med. Chem. 4:1355-1359 
  25. Takeya, K., Qiao, Z.S., Hirobe, C. and Itokawa, H. 1996b. Cytotoxic azadirachtin-type limonoids from Melia azedarach. Phytochemistry 42:709-712 
  26. Thayer, P.S., Himmelfarb, P. and Watts, G.L. 1971. Cytotoxicity assays with L1210 cells in vitro: comparison with L1210 in vivo and KB cells in vitro. Cancer Chemother. Rep. 2:21-25 

이 논문을 인용한 문헌 (0)

  1. 이 논문을 인용한 문헌 없음

원문보기

원문 PDF 다운로드

  • ScienceON :
  • KCI :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일