Lee, Haeng-Byung
(Interdisciplinary Program, Department of Agricultural Biotechnology, Seoul National University)
,
Lee, Hyun-Kyung
(Interdisciplinary Program, Department of Agricultural Biotechnology, Seoul National University)
,
Kim, Jun-Ran
(WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University)
,
Ahn, Young-Joon
(WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University)
The antibacterial activity of materials derived from the rhizome of Alpinia officinarum (Zingiberaceae) against Helicobacter pylori ATCC 43504, ATCC 700392, and ATCC 700824 was examined using paper-disc diffusion and agar dilution methods. Results were compared with those following treatment with cu...
The antibacterial activity of materials derived from the rhizome of Alpinia officinarum (Zingiberaceae) against Helicobacter pylori ATCC 43504, ATCC 700392, and ATCC 700824 was examined using paper-disc diffusion and agar dilution methods. Results were compared with those following treatment with currently used antibiotics: amoxicillin, metronidazole, and tetracycline. The bioactive principle was characterized as the diarylheptanoid 5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-phenyl-3-heptanone by spectroscopic analysis. This compound was isolated from A. officinarum leaves as a new anti-H. pylori principle. Against H. pylori ATCC 43504, ATCC 700392, and ATCC 700824, the antibacterial activity of the diarylheptanoid (48, 24, and $24{\mu}g$/mL) was comparable to that of metronidazole (32, 16, and $16{\mu}g$/mL) but less effective than that of either amoxicillin (0.06, 0.06, and $0.03{\mu}g$/mL) or tetracycline (0.5, 1, and $0.5{\mu}g$/mL), based on minimum inhibitory concentrations. A. officinarum rhizome-derived materials, particularly the diarylheptanoid isolated, merit further study as potential antibacterial functional food products or therapeutic products for prevention or eradication from humans from diseases caused by H. pylori.
The antibacterial activity of materials derived from the rhizome of Alpinia officinarum (Zingiberaceae) against Helicobacter pylori ATCC 43504, ATCC 700392, and ATCC 700824 was examined using paper-disc diffusion and agar dilution methods. Results were compared with those following treatment with currently used antibiotics: amoxicillin, metronidazole, and tetracycline. The bioactive principle was characterized as the diarylheptanoid 5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-phenyl-3-heptanone by spectroscopic analysis. This compound was isolated from A. officinarum leaves as a new anti-H. pylori principle. Against H. pylori ATCC 43504, ATCC 700392, and ATCC 700824, the antibacterial activity of the diarylheptanoid (48, 24, and $24{\mu}g$/mL) was comparable to that of metronidazole (32, 16, and $16{\mu}g$/mL) but less effective than that of either amoxicillin (0.06, 0.06, and $0.03{\mu}g$/mL) or tetracycline (0.5, 1, and $0.5{\mu}g$/mL), based on minimum inhibitory concentrations. A. officinarum rhizome-derived materials, particularly the diarylheptanoid isolated, merit further study as potential antibacterial functional food products or therapeutic products for prevention or eradication from humans from diseases caused by H. pylori.
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