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논문 상세정보

Abstract

Fifty percent ethanol extract of Lythrum salicaria Linne root (LSR) was tested in vitro on antioxidant activity, and furthermore was investigated on antioxidative and fibrosis protecting activities in $CCL_4$-induced liver fibrosis rat model. Ratio of hepatic GSH/GSSG (reduced glutathione/oxidized glutathione) as bio-parameter of antioxidant level in $CCL_4$ plus LSR-treated rats for 6 weeks significantly increased from 2.8- to 5.7-fold than that of $CCL_4$-treated rats at p < 0.05. Thiobarbituric acid reactive substances (TBARS) contents in $CCL_4$ plus LSR-treated rats ranged from 1.57- to 2.19-fold of normal rats and were lower than those in $CCL_4$ plus silymarin-treated rats ($1.78{\sim}2.46$-fold of normal rats) (p < 0.05). Amounts of hydroxyproline of liver tissue showing the content of total collagen, a parameter of fibrosis, in $CCL_4$ plus LSR-administrated rat livers were $4.9{\sim}8.8{\mu}g$/mg ($-47{\sim}-71%$, compared with that in $CCL_4$-treated rat livers ($16.6{\mu}g$/mg tissue), which were significantly lower than those in $CCL_4$ plus silymarin-administrated rats being $8.4{\sim}11.7{\mu}g$/mg ($-30{\sim}-50%$). This collagen reducing effect of liver tissue in $CCL_4$ plus LSR-treated rats was supported by histological observation using microscopy assay. From the results, we conclude that the root of L. salicaria have efficient antioxidant potential and effective antifibrotic activities.

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이 논문을 인용한 문헌 (5)

  1. Lee, Seung-Eun ; Park, Chun-Geun ; Kim, Sun-Lim ; Soe, Jin-Sook ; Kim, Geum-Soog ; Lee, Jeong-Hoon ; Park, Chung-Berm ; Kim, Young-Chul 2010. "Chemical Component Contents and Physiological Activity of Lythrum salicaria L. According to Plant Parts and Collected Time" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 18(5): 298~304 
  2. Lee, Seung-Eun ; Kim, Geum-Soog ; Han, Hee-Sun ; Lee, Eun-Suk ; Kim, Young-Ok ; Lee, Jeong-Hoon ; Seong, Nak-Sul ; Lee, Sang-Won ; Kim, Young-Chul 2010. "Biological Activity of Organic Solvent Fractions from Lythrum salicaria L. (Root)" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 18(5): 323~328 
  3. Kim, Hee-Yeon ; Lim, Sang-Hyun ; Park, Min-Hee ; Park, Yu-Hwa ; Ham, Hun-Ju ; Lee, Ki-Yun ; Park, Dong-Sik ; Kim, Kyung-Hee ; Kim, Song-Mun 2010. "Biological Activities in the Leaf Extract of Lythrum salicaria L." 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 18(6): 409~415 
  4. Kim, Hee-Yeon ; Lim, Sang-Hyun ; Kwon, Chang-Ju ; Park, Yu-Hwa ; Lee, Kwang-Jae ; Park, Dong-Sik ; Kim, Kyung-Hee ; Kim, Song-Mun ; Park, Chung-Berm 2011. "Effect of Lythrum salicaria L. Ethanol Extract on Lipid Metabolism and Anti-Obesity in Rat Fed High Fat Diet" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 19(5): 319~324 
  5. Lee, Seung-Eun ; Kim, Geum-Soog ; Lee, Jeong-Hoon ; Kang, Yong-Ku ; Lee, Eun-Suk ; Choi, Je-Hun ; Lee, A-Reum ; Park, Su-Jin ; Noh, Hyung-Jun ; Kim, Seung-Yu 2011. "Effect of Plant Part Extracts of Lythrum salicaria L. on Chronically Alcohol-Administrated Rat" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 19(5): 334~340 

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