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논문 상세정보

Abstract

Oxczaasssaidative stress plays an important role in neuronal cell death, which is associated with neurodegenerative conditions such as Alzheimer's and Parkinson's disease. This study evaluated the neuroprotective effect of Euryale ferox (EF) extracts against glutamate-induced cytotoxicity in hybridoma N18-RE-105 cells. Specifically, neuroprotective effects of methanol and ethanol extracts were evaluated by the MTT reduction assay. The ethanol extracts of EF displayed dose dependent protection against neuronal cell death induced by 20 mM of glutamate. Furthermore, the ethanol extracts of EF was sequentially fractionated with hexane, diethyl ether, ethyl acetate, and water layer according to degree of polarity. The hexane fractions exhibited neuroprotective effect against glutamate-stressed N18-RE-105 cells. Overall, results suggest that EF extracts can potentially be used as chemotherapeutic agents against neuronal diseases.

참고문헌 (20)

  1. Buckman, T.D., Sutphin, M.S., and Mitrovic, B., Oxidative stress in a clonal cell line of neuronal origin: effects of antioxidant enzyme modulation. J. Neurochem., 60, 2046-2058 (1993) 
  2. Choi, SJ., Yoon, K.Y., Cho,i S.G., Kim, D.O., Oh, S., Jun, W.J., Shin, D.H., Cho, S.H., and Heo, H.J., Protective effect of Acanthopanax senticosus on oxidative stress induced PC12 cell death. Food. Sci. Biotechnol., 16, 1035-1040 (2007) 
  3. Claudia, M.F. and Catarina, R., Glutamate toxicity on PC12 cell line involves glutathione (GSH) depletion and oxidative stress. Free. Radic. Biol. Med., 23, 637-647 (1997) 
  4. Das, S., Der, P., Raychaudhuri, U., Maulik, N., and Das, D.K., The effect of Euryale ferox (makhana), an herb of aquatic origin, on myocardial ischemic reperfusion injury. Mol. Cell. Biochem., 289, 55-63 (2006) 
  5. Greenwood, S.M. and Connolly, C.N., Dendritic and mitochondrial changes during glutamate excitotoxicity. Neuropharmacology., 53, 891-898 (2007) 
  6. Hou, R.C.W., Huang, H.M., Tzen, J.T.C., and Jeng, K.C., Protective effects of sesamin and sesamolin on hypoxic neuronal and PC12 cells. J. Neurosci. Res., 74, 123-133 (2003) 
  7. Ito, Y., Oumi, S., Nagasawa, T., and Nishizawa, N., Oxidative stress induces phosphoenolpyruvate carboxykinase expression in H4IIE cells. Biosci. Biotech. Biochem., 70, 2191-2198 (2006) 
  8. Jeon, KI., Park, E.J., Park, H.R., Jeon, Y.J., Cha, S.H., and Lee, S.C., Antioxidant activity of far-infrared radiated rice hull extracts on reactive oxygen species scavenging and oxidative DNA damage in human lymphocytes. J. Med. Food., 9, 42-48 (2006) 
  9. Kazushi, K,, Sayaka, N., Shin, S., Kenichi, Y., and Tatsuya, O., Production of reactive oxygen species (ROS) by various marine fish species during the larval stage. Biosci. Biotechnol. Biochem., 71, 2029-2033 (2007) 
  10. Kodach, L.L., Bos, C.L., Duran, N., Peppelenbosch, M.P., Ferreira, C.V., and Hardwick, J.C.H., Violacein synergistically increases 5- fluorouracil cytotoxicity, induces apoptosis and inhibits Akt-mediated signal transduction in human colorectal cancer cells. Carcinogenesis., 27, 508-516 (2006) 
  11. Lee, S.M., Yoon, M.Y., and Park, H.R., Protective effects of Paeonia lactiflora Pall on hydrogen peroxide-induced apoptosis in PC12 cells. Biosci. Biotech. Biochem., 72, 1272-1277 (2008) 
  12. Lonigro, R., Donnini, D., Fabbro, D., Prerrella, G., Damante, G., Ambesci, I.F.S., and Curcio, F., Thyroid-specific gene expression is differentially influenced by intracellular glutathione level in FRTL-5 cells. Endocrinology., 141, 901-909 (2000) 
  13. Monaghan, D.T., Bridges, R.J., and Cotman, C.W., The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system. Annu. Rev. Pharmacol. Toxicol., 29, 365-402 (1989) 
  14. Penugonda, S., Mare, S., Goldstein, G., Banks, W.A., and Ercal, N., Effects of N-acetylcyteine amide (NACA), a novel thiol antioxidant against glutamate-induced cytotoxicity in neuronal cell line PC12. Brain. Res., 1056, 132-138 (2005) 
  15. Puri, A., Sahai, R., Singh, K.L., Sazena, R.P., Tandon, J.S., and Sazena, K.C., Immunostimulant activity of dry fruits and plant materials used in Indian traditional medical system for mothers after child birth and invalids. J. Ethnopharmacol., 71, 89-92 (2000) 
  16. Row, L.C., Ho, J.C., and Chen, C.M., Cerebrosides and tocopherol trimers from the seeds of Euryale ferox. J. Nat. Prod., 70, 1214-1217 (2007) 
  17. Tan, S., Sagara, Y., Liu, Y., Maher, P., and Schubert, D., The regulation of reactive oxygen species production during programmed cell death. J. Cell. Biol., 141, 1423-1432 (1998) 
  18. Wang, L., Hinoi, E., Takemori, A., Nakamichi, N., and Yoneda, Y., Glutamate inhibits chondral mineralization through apoptotic cell death mediated by retrograde operation of the cystine/glutamate antiporter. J. Biol. Chem., 281, 24553-24565 (2006) 
  19. Wen, J., You, K.R., Lee, S.Y., Song, C.H., and Kim, D.G., Oxidative stress-mediated apoptosis. J. Biol. Chem., 277, 38954-38964 (2002) 
  20. Yoon, M.Y., Lee, H.J., Lee, B.B., Lee, S.M., Kim, J.Y., Kim, Y.S., Park, E.J., and Park, H.R., Protective effect of Schizonepeta tenuifolia briquet extracts on oxidative DNA damage in human leucocytes and on hydrogen peroxide-induced cytotoxicity in PC12 cells. Food. Sci. Biotechnol., 5, 858-862 (2007) 

이 논문을 인용한 문헌 (1)

  1. Kang, Min Gu ; Kim, Young Hwa ; Im, A Rang ; Nam, Byung Soo ; Chae, Sung Wook ; Lee, Mi Young 2014. "Antidepressant-like Effects of Schisandra chinensis Baillon Water Extract on Animal Model Induced by Chronic Mild Stress" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 22(3): 196~202 

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