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KSBB Journal, v.25 no.3, 2010년, pp.223 - 229
박근형 (호서대학교 식품생물공학과) , 조은혜 (호서대학교 식품생물공학과) , 김남찬 (호서대학교 식품생물공학과) , 채희정 (호서대학교 식품생물공학과)
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Fucoidans, polysaccharides that are composed of fucose, uronic acids, galactose and xylose, are one of the main constituents of brown seaweeds. For the past decade algal fucoidans have been extensively studied due to their biological activities including anticoagulant, antiinflammatory, antitumor, c...
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| 핵심어 | 질문 | 논문에서 추출한 답변 |
|---|---|---|
| 후코이단이란 무엇인가? | 이와 관련하여 한국과 일본 및 중국의 동아시아에서 오랜 기간 섭취하여 온 미역과 다시마 등의 갈조류에 함유된 고분자 다당체인 후코이단 (fucoidan)의 여러가지 기능성에 대한 관심이 집중되고 있다 [6]. 후코이단은 특이적으로 갈조류 (미역, 다시마, 톳, 대황, 곰피, 감태 등)의 세포벽 성분인 점질 다당에 함유되어 있는 다당류로서 다시마와 미역포자엽의 건조중량 대비 3～4%의 소량이 함유되어 있다 [7]. 후코이단은 갈조류의 채취시기 및 종에 따라 후코이단의 평균 분자량이 100,000-2,000,000 Da으로 다양하며, 후코이단의 생리활성에 중요한 영향을 미치는 fucose 함량 및 황산기 함량도 차이가 난다 [8]. | |
| 후코이단의 분리정제 방법 중 효소적 방법의 장단점은 무엇인가? | 현재 높은 분자량을 가진 고분자 후코이단을 저분자하기 위하여 분해효소를 이용한 가수분해법이 주로 연구되고 있다 [44]. 효소적 방법은 특정한 결합만을 가수분해시킬 수 있는 장점을 갖고 있으나, 효소 확보의 어려움, 효소반응을 위한 고분자 다당체의 낮은 용해도 그리고 산업화 공정에서 효소사용으로 인한 높은 생산 단가 등 실용화에 제한이 있다. 또한 산처리에 의한 가수분해 방법도 제시되고 있으나, 산처리 후 가혹한 조건에서 다당류의 분해가 일어나기 때문에 황산기 함량이 낮아지고 단당이 대량으로 생산될 가능성이 높은 단점을 가지고 있다. | |
| 후코이단의 원료로 사용되는 물질은 무엇이 있는가? | 후코이단의 원료로서는 미역포자엽, 다시마, 톳, 큰실말 (모즈크), 대황 등의 해조류가 사용되고 있다. 해조류의 종류에 의해 후코이단의 황산기 함량이나 구조가 차이가 나는데 [37-41], 국내에서 생산하는 다시마, 미역포자엽 등은 후코이단과 알긴산으로 불리는 다당을 포함하고 있어 고도의 분리정제 기술을 요하고 있으나, 일본의 큰실말에는 알긴산이 거의 포함되어 있지 않다. |
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