고양이의 귀에서 발생하는 염증성 용종은 중이 또는 귀이두관에서 유래하여 인두 또는 외이도관으로 파급되는 비종양성, 염증성 성장을 말한다. 두 마리의 2세령 암컷 고양이(Russian blue)가 이도 삼출물, 외이의 가피 형성, 머리 또는 귀를 흔드는 증상을 약 2-3주간 나타내었다. 이도에서 외과적으로 적출한 두 개의 종괴를 검사하였다. 병리조직학적으로 이 종괴들은 증식된 섬모상피 또는 비각화중층편평상피로 피복되어 있으며, 부분적인 미란 또는 궤양이 형성되어 있었다. 종괴는 증식된 결합조직과 광범위한 단핵세포 침윤으로 구성되어 있었다. 면역조직화학 염색을 실시한 결과 약 90%의 단핵세포들은 CD3 양성인 T 림프구로 증명되었다. 종괴에 대한 중합효소연쇄반응을 실시하였으나 바이러스 병원체는 모두 음성으로 확인되었다. 따라서 임상 소견 및 병리학적 소견을 토대로 두 종괴는 고양이의 중이에서 유래한 염증성 용종으로 확진되었다.
고양이의 귀에서 발생하는 염증성 용종은 중이 또는 귀이두관에서 유래하여 인두 또는 외이도관으로 파급되는 비종양성, 염증성 성장을 말한다. 두 마리의 2세령 암컷 고양이(Russian blue)가 이도 삼출물, 외이의 가피 형성, 머리 또는 귀를 흔드는 증상을 약 2-3주간 나타내었다. 이도에서 외과적으로 적출한 두 개의 종괴를 검사하였다. 병리조직학적으로 이 종괴들은 증식된 섬모상피 또는 비각화중층편평상피로 피복되어 있으며, 부분적인 미란 또는 궤양이 형성되어 있었다. 종괴는 증식된 결합조직과 광범위한 단핵세포 침윤으로 구성되어 있었다. 면역조직화학 염색을 실시한 결과 약 90%의 단핵세포들은 CD3 양성인 T 림프구로 증명되었다. 종괴에 대한 중합효소연쇄반응을 실시하였으나 바이러스 병원체는 모두 음성으로 확인되었다. 따라서 임상 소견 및 병리학적 소견을 토대로 두 종괴는 고양이의 중이에서 유래한 염증성 용종으로 확진되었다.
Inflammatory polyps in feline ear are nonneoplastic, inflammatory growths that arise from the middle ear or the eustachian tube and extended into the pharynx or external ear canal. Two 2-year-old female Russian blue cats showed 2-3 weeks history of aural discharge, crust formation in external ear, a...
Inflammatory polyps in feline ear are nonneoplastic, inflammatory growths that arise from the middle ear or the eustachian tube and extended into the pharynx or external ear canal. Two 2-year-old female Russian blue cats showed 2-3 weeks history of aural discharge, crust formation in external ear, and head or ear shaking. Two masses were surgically excised from ear canal, and submitted for diagnosis. Histopathologically, these masses were covered with hyperplastic ciliated epithelium or nonkeratinizing squamous epithelium with partial erosion and ulceration. The core of masses was consisted of proliferated connective tissue and massive infiltration of mononuclear cells. Immunohistochemically, about 90% of infiltrated mononuclear cells demonstrated CD3 positive T cell. According to both polymerase chain reaction (PCR) and reverse transcriptase-PCR, tissues samples were negative for feline viral pathogens. Based on the clinical, gross, histopathologic findings, these two cases were diagnosed as inflammatory polyps originated from the middle ear in cats.
Inflammatory polyps in feline ear are nonneoplastic, inflammatory growths that arise from the middle ear or the eustachian tube and extended into the pharynx or external ear canal. Two 2-year-old female Russian blue cats showed 2-3 weeks history of aural discharge, crust formation in external ear, and head or ear shaking. Two masses were surgically excised from ear canal, and submitted for diagnosis. Histopathologically, these masses were covered with hyperplastic ciliated epithelium or nonkeratinizing squamous epithelium with partial erosion and ulceration. The core of masses was consisted of proliferated connective tissue and massive infiltration of mononuclear cells. Immunohistochemically, about 90% of infiltrated mononuclear cells demonstrated CD3 positive T cell. According to both polymerase chain reaction (PCR) and reverse transcriptase-PCR, tissues samples were negative for feline viral pathogens. Based on the clinical, gross, histopathologic findings, these two cases were diagnosed as inflammatory polyps originated from the middle ear in cats.
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가설 설정
H&E, Bar = 100 µm. Insert: Infiltrated lymphocytes are CD3 positive T cells. IHC.
제안 방법
Submitted two biopsy masses were trimmed, embedded in paraffin, sectioned at 3 µm, and stained with hematoxylin and eosin (H&E) for light microscopic examination.
대상 데이터
Two cases of mass were surgically excised in local animal hospital and fixed in 10% buffered formalin. Biopsy samples taken at surgery were submitted to the pathology laboratory at the College of Veterinary Medicine in Jeju National University. According to follow-up information from the owners, there was no recurrence of ear mass in each cat.
이론/모형
Additional paraffin-embedded sections were available for immunohistochemistry (IHC). After mounting on silane coated glass slides, each section was stained by a labeled streptavidin-biotin peroxidase method. For antigen retrieval, sections were incubated with Target Retrieval solution (Dako code S3307) or EDTA.
참고문헌 (16)
Allen HS, Broussard J, Noone K. Nasopharyngeal diseases in cats: A retrospective study of 53 cases (1991-1998). J Am Anim Hosp Assoc 1999; 35: 457-461.
Cook LB, Bergman RL, Bahr A, Boothe HW. Inflammatory polyp in the middle ear with secondary suppurative meningoencephalitis in a cat. Vet Radiol Ultrasound 2003; 44: 648-651.
MacPhail CM, Innocenti CM, Kudnig ST, Veir JK, Lappin MR. Atypical manifestations of feline inflammatory polyps in three cats. J Feline Med Surg 2007; 9: 219-225.
Sykes JE, Studdert, Browning GF. Detection and strain differentiation of feline calicivirus in conjunctival swabs by RT-PCR of the hypervariable region of the capsid protein gene. Arch Virol 1998; 143: 1321-1334.
Suchy A, Bauder B, Gelbmann W, Lohr CV, Teifke JP, Weissenbock H. Diagnosis of feline herpesvirus infection by immunohistochemistry, polymerase chain reaction, and in situ hybridization. J Vet Diagn Invest 2000; 12: 186-191.
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