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Dolichos biflorus Linn. (Fabaceae), commonly known as Horse gram is a medicinal plant, used in folk medicine for treating kidney stones and diabetes mellitus. The purpose of the present study was to investigate the effects of daily oral feeding of various doses of methanolic extract of Dolichos biflorus seeds (DB) for 42 days on blood glucose concentrations and kidney functions in Alloxan-diabetic rats. Plasma glucose levels, body weight, serum creatinine, and urinary albumin levels were monitored on $15^{th}$, $29^{th}$, $43^{rd}$ day. Renal hypertrophy was assessed as the ratio between the kidney weight and body weight of the rats. Plasma glucose concentrations in Alloxan-diabetic rats were significantly reduced by the administration of DB (350 mg/kg) and DB (700 mg/kg) on day 15 and onwards (P < 0.01). After 15 days of Alloxan administration urinary albumin levels (UAE) were over 5 fold higher in diabetic controls as compared to normal controls. Treatment with DB significantly prevented the rise in UAE levels from day 15 to 43 in comparison to diabetic controls (P < 0.01). Renal hypertrophy was significantly higher in diabetic controls as compared to non-diabetic controls. Treatments with DB (350 mg/kg) and DB (700 mg/kg) significantly prevented renal hypertrophy (P < 0.01) as compared to diabetic controls. DB (175 mg/kg) failed to modify renal hypertrophy. Thus the present study indicates that methanolic extract of Dolichos biflorus may be useful in management of hyperglycemia and kidney functions in Alloxan-diabetic rats.

참고문헌 (25)

  1. Bretzel RG. (1997) Prevention and slowing down the progression of the diabetic nephropathy through antihypertensive therapy. J. Diab. Complications 11, 112-122. 
  2. Di Landro D, Catalono C, Lambertini D. (1998) The effect of metabolic control on development and progression of diabetic nephropathy. Nephrol. Dial. Transplant 13, 35-43. 
  3. Duke JA, Ayensd ES. (1985) Medicinal Plants of China, pp. 512, Reference Publication, (Algonac, Michigan), China. 
  4. Eisenberg DM, Kessler RC, Foster C, Norlock FE, Calkins DR, Delbanco TL. (1993) Unconventional al medicine in the United States. Prevalence, costs, and patterns of use. New Engl. J. Med. 328, 246–252. 
  5. Garimella TS, Jolly CI. Narayanan S. (2001) In vitro studies on antilithiatic activity of seeds of Dolichos biflorus Linn. and rhizomes of Bergenia ligulata Wall.Phytother. Res. 15, 351-355. 
  6. Hemadri PK, Sasibhushana RS. (1985) Antifertility, abortifacient and fertility promoting drug from Dandakaranya. Ancient Sci. Life 32, 103. 
  7. Kang SS, Fears R, Noirot S, Mbanya JN, Yudkin J. (1982) Changes in metabolism of rat kidney and liver caused by experimental diabetes by dietarysucrose. J. Diabetol. 22, 285–288. 
  8. Kirtikar KR, Basu BD. (1984) Indian Medicinal Plants, pp. 804, Ed. Bishen S, Mahendra PS. Vol. 1, 2nd edn. Dehra Dun, India. 
  9. Maclennan AH, Wilson DH, Taylor AW. (1996) Prevalence and cost of alternative medicine in Australia. Lancet 347, 569–573. 
  10. Marcantoni C, Ortalda V, Lupo A, Maschio G. (1998) Progression of renal failure in diabetic nephropathy. Nephrol. Dial. Transplant 13, 16-19. 
  11. Mauer SM, Brown DM, Matas AJ, Steeffes MW. (1978) Effects of pancreatic islets transplantation on the increased urinary albumin excretion rates in intact and unephrectomized rats with diabetes mellitus. Diabetes 27, 959–964. 
  12. Mehta SL, Simlot MM. (1982) An acid stable trypsin –chymotrypsin inhibitior from horse gram (Dolichos biflorus). J. Biosci. 4, 295-306. 
  13. Muthu AK, Sethupathy S, Manavalan P, Karar PK. (2005) Hypolipidemic effect of methanolic extract of Dolichos biflorus Linn. in high fat diet fed rats. Indian J. Exp. Biol. 43, 522-525. 
  14. Muthu AK, Sethupathy S, Manavalan P, Karar PK. (2006) Antioxidant potential of methanolic extract of Dolichos biflorus Linn. in high fat diet fed rabbits. Indian J. Pharmacol. 38, 131-132. 
  15. Pant MC, Uddin I, Bhardwaj UR, Tewari RD. (1968) Blood sugar and Total cholesterol lowering effect of Glycine soja, mucuna pruriens (D.C.) and Dolichosbiflorus Linn. Seed diets in normal fasting albino rats. Indian J. Med. Res. 56, 1808-1812. 
  16. Quisumbing E. (1951) Medicinal Plants of Philippines pp. 1, Tech Ball Lp. Rep., Dept. Agri, Nat Resources Manilla, Philippines. 
  17. Rasch R, Mogensen CI. (1980) Urinary excretion of albumin and total protein in normal and streptozotocin diabetic rats. Acta Endocrinol. 95, 376–381. 
  18. Rasch R. (1979) Prevention of diabetic glomerulopathy in streptozotocin diabetic rats by insulin treatment. Kidney size and glomerular volume. Diabetologia. 16,124–128. 
  19. Rasch R. (1980) Prevention of diabetic glomerulopathy in streptozotocin diabetic rats by insulin treatment. Diabetologia 18, 413–416. 
  20. Samiulla DS, Harish MS. (2001) Comparative effect of NR-AG-1 and NR-AG-2 (Polyherbal formulation) against gentamycin-induced nephrotoxicity in rats. J. Natural Rem. 1, 42-44. 
  21. Sassy-Prigent C, Heudes D, Jouquey S, Auberval D, Belair, MF, Michel O, Hamon G, Bariety J, Bruneval P. (1995) Morphometric detection of incipient glomerular lesions in diabetic nephropathy in rats. Protective effects of ACE inhibition. Lab. Invest. 73, 64–71. 
  22. Unnikrishan MC, Kurtan R. (1990) Tumour reducing and anticarcinogenic activity of selected spices. Cancer Lett. 51, 85. 
  23. Upadhayay VP, Pandey K. (1984) Ayurvedic approach to diabetes mellitus and its management by indigenous resources. In: Diabetes Mellitus in Developing Countries, edited by Bajaj J. pp. 375–377, Interprint, New Delhi, India. 
  24. Viberti GC, Hill RD, Jarrett RJ, Argyropoulous A, Mahmud U, Keen H. (1982) Microalbuminuria as a predictor of clinical nephropathy in insulindependentdiabetes mellitus. Lancet 1, 1430–1432. 
  25. Yotsumoto T, Naitoh T, Shikada K, Tanaka S. (1997) Effects of specific antagonists of angiotensin II receptors and captopril on diabetic nephropathy inmice. Jpn. J. Pharmacol. 75, 59–64. 

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