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Abstract

Twenty six compounds (1-26) were isolated from the root barks of Ulmus davidiana var. japonica. The anti-inflammatory activity of the isolated compounds were evaluated agai nst the generation of inflammatory chemical mediators in bone marrow-derived mast cells. Among them, compounds 10, 11, 13, 15 and 19 inhibited not only cyclooxygenase-2 dependent prostaglandin $D_2$ generation but also 5-lipoxygenase dependent leukotrien $C_4$ generation in a concentration-dependent manner. In addition, compounds 11, 12, 13, 15 and 19 also inhibited $\beta$-hexosaminidase release, a marker of mast cell degranulation reaction, from bone marrow-derived mast cell. These results suggest that the anti-inflammatory activity of U. davidiana might in part occur by both the inhibition of eicosanoid generations and the degranulation reaction of mast cells.

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이 논문을 인용한 문헌 (4)

  1. 송정호, 장경환, 임효인, 박완근, 배관호 2011. "느릅나무 자연집단(自然集團)의 시과(翅果), 종자(種子), 발아(發芽) 및 생장특성(生長特性) 변이(變異)" 韓國林學會誌 = Journal of Korean Forest Society, 100(2): 226~231 
  2. Zheng, Ming Shan, Li, Gao, Li, Ying, Seo, Chang-Seob, Lee, Yeun-Kyung, Jung, Jun-Sub, Song, Dong-Keun, Bae, Hong-Beom, Kwak, Sang-Hyun, Chang, Hyun-Wook, Kim, Jae-Ryong, Son, Jong-Keun 2011. "Protective Constituents against Sepsis in Mice from the Root Barks of Ulmus davidiana var. japonica" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 34(9): 1443~1450 
  3. Hosny, Mohammed, Zheng, Ming-Shan, Zhang, Haiyan, Chang, Hyun-Wook, Woo, Mi-Hee, Son, Jong-Keun, Lee, Sunny Kyung-Seon 2014. "(-)-Catechin glycosides from Ulmus davidiana" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 37(6): 698~705 
  4. 이인환, 권다혜, 이선희, 이성도, 김덕원, 이종환, 현숙경, 김철민, 김병우, 강경화, 황혜진, 정경태 2014. "왕느릅나무 껍질 열수 추출물의 마우스에서의 in vivo 면역조절 효과" 생명과학회지 = Journal of life science, 24(10): 1151~1156 

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