$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

고지방 식이 흰쥐에서 오가피 추출물의 항산화 효과 및 지질 개선 효과

Antioxidant Effects and Improvement of Lipid Metabolism of Acanthopanacis cortex Water Extract in Rats Fed High Fat Diet

초록

오가피 추출물이 고지방 식이를 급여한 흰쥐의 체내 지질대사, 심혈관계질환지수 항산화능 및 항산화 효소계에 어떤 영향을 미치는지 알아보고자 하였다. 연구 결과를 요약하면 아래와 같다. 1. 식이 섭취량은 고지방 식이군이 정상 식이군에 비해 유의적 (p<0.05)으로 감소하였으며, 식이 효율은 유의적 (p<0.05)으로 높았다. 최종 체중과 체중 증가량은 고지방 식이군과 정상 식이군 간에 유의적인 차이가 없었다. 2. 혈장의 HDL-콜레스테롤은 고지방 식이군에서 오가피 추출물의 첨가로 증가하였으며 LDL-콜레스테롤은 감소하였다(p<0.05). 중성지방은 고지방 식이군이 정상 식이군에 비해 증가하였으며, 오가피 추출물 섭취로 감소하였다(p<0.05). 간의 총 지질은 군 간에 차이가 없었고, 총콜레스테롤은 정상 식이군에 비해 고지방 식이군에서 유의하게 증가하였으나(p<0.05) 오가피 추출물의 첨가로 유의하게 감소하였으며(p<0.05), 중성지방 농도는 정상 식이군에 비하여 고지방 식이군에서 유의적으로 증가하였다(p<0.05). 3. 심혈관위험지수와 동맥경화지수는 고지방 식이군에 비하여 고지방 식이 오가피 추출물군에서 유의적으로 감소하였다(p<0.05). 4. 혈장과 간의 지질 과산화물 농도는 정상 식이군에서 오가피 추출물 섭취로 유의하게 감소하였다(p<0.05). 혈장의 TAS 값은 고지방 섭취로 감소되었으나, 오가피 추출물 섭취로 유의하게(p<0.05) 증가되었다. 5. 간의 SOD, catalase 및 GST 활성도는 정상 식이군과 고지방 식이군에서 오가피 추출물 첨가군이 오가피 추출물 무첨가군에 비해 유의적으로 증가하였고(p<0.05), glutathione peroxidase 활성도와 glutathione 함량은 고지방 식이군에서 오가피 추출물 첨가로 유의하게(p<0.05) 증가하였다. 이상의 결과에서 고지방 식이를 공급하였을 때 오가피 추출물 섭취는 혈장의 HDL-콜레스테롤 농도는 높이고, 혈장과 간의 총콜레스테롤과 중성지방의 농도는 낮추어 심혈관 위험지수와 동맥경화지수를 효과적으로 감소시키므로 지질 개선 및 고지혈증에 대한 개선 효과가 있을 것으로 보인다. 또한 항산화 효소 활성을 증가시켜 혈장과 간의 지질 과산화물 생성을 억제시키므로 항산화제로서 작용할 수 있음을 시사해 주고 있다. 그러나 지질 개선 및 천연 항산화제로서 작용할 수 있는 오가피의 용량에 대해서는 좀 더 많은 연구가 필요한 것으로 사료된다.

Abstract

The effects of an Acanthopanacis cortex water extract on lipid levels, lipid peroxide, total antioxidant status and antioxidant enzyme activities were evaluated in rats fed one of the following diets for six weeks: normal diet and deionized water (ND), normal diet and Acanthopanacis cortex water extract (NDC), high fat diet and deionized water (HFD), high fat diet and Acanthopanacis cortex water extract (HFDC). The food intakes were significantly lower, but the food efficiency ratios were significantly higher in the high fat diet groups. The level of HDL-cholesterol in the plasma was significantly increased and the levels of LDL-cholesterol and triglyceride in the plasma were significantly decreased by the Acanthopanacis cortex water extract in the high fat diet groups. As a a result, the AI (atherogenic index) and CRF (cardiac risk factor) were significantly lower in the high fat diet groups that were treated with Acanthopanacis cortex water extract. The triglyceride and the total cholesterol of the liver were also significantly upregulated in the high fat diet groups, while the total cholesterol of the liver decreased in response to treatment with Acanthopanacis cortex water extract (HFDC). The plasma and liver concentrations of thiobarbituric acid reactive substances (TBARS) were significantly reduced by the addition of Acanthopanacis cortex water extract to the normal diet groups. The total antioxidant status (TAS) in the plasma was significantly upregulated by adding Acanthopanacis cortex water extract to the high fat diet groups. The activities of SOD, catalase and GST were also significantly higher in the Acanthopanacis cortex water extract groups when compared to the ionized water groups. The activity of GSH-Px and the concentration of GSH in the liver were significantly higher following the addition of Acanthopanacis cortex water extract to the high fat diet groups. Taken together, these results suggest that a supplementation of the diet of rats fed a high fat diet with Acanthopanacis cortex water extract improves lipid metabolism, reduces lipid peroxide and improves the activities of antioxidant enzymes, which may have favorable effects on antioxidant systems by improving the total antioxidant status (TAS).

저자의 다른 논문

참고문헌 (37)

  1. Aebi H (1974) Catalase in vitro. Methods in Enzymology 105: 121-126. 
  2. Arthur JR, Boyne R (1985) Superoxide dismutase and glutathione peroxidase activities in neutrophils from selenium deficient and copper deficient cattle. Life Sci 36: 1569-1575. 
  3. Choi HS, Kim YR, Han JH, Park SH (2008) Effect of Eleutherococcus senticoccus and several oriental medicinal herbs extracts on serum lipid concentrations. Korean J Food and Nutr 21: 210-217. 
  4. Chung CK, Han SS, Lee SY, Oh DH, Choi SY, Kang IJ, Nam SM (1999) Effects of Houttyunia cordata ethanol extracts on serum lipids and antioxidant enzymes in rats fed high fat diet. J Korean Soc Food Sci Nutr 28: 205-211. 
  5. Ciriolo MR, Rossi L, Mavelli I, Rotilio G, Borzatta V, Cristofori M, Barbanti M (1984) The effects of hypolipidernic agents derived from procetofenic acid on the activity of superoxide dismutase and glutathione peroxidase and on malonydialdehyde production of rat liver. Arzneimittelforschung 34: 456-457. 
  6. Ellman GL (1959) Tissue sulfhydryl group. Arch Biochem Biophys 82: 70-72. 
  7. Finley PR, Schifman RB, Williams RJ, Luchit DA (1978) Cholesterol in high-density lipoprotein. Clin Chem 24: 931-933. 
  8. Folch J, Lees M, Sioanestanley GH (1957) A simple method for the isolation and purification of total lipids from animal tissue. J Biol Chem 226: 497-509. 
  9. Friedwald WT, Levy RI, Fedreicson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18: 499-506. 
  10. Habig WH, Pabst MJ, Jakoby WB (1974) Glutathione S-transferase: The first enzymatic step in mercapture acid reaction. Anal Biochem 249: 7130-7139. 
  11. Han EG, Sung IS, Moon HG, Cho SY (1998) Effect of Codonopsis Ianceolata water extract on the levels of lipid in rats fed high fat diet. J Korean Soc Food Sci Nutr 27: 940-944. 
  12. Han YS (2002) A study on the effect of antiinflammatory plant extracts on melanogenesis. Ph D Thesis Ajou University. Suwon. Korea. 
  13. Kim EY, Baik IH, Kim JH, Kim SR, Rhyu MR (2004) Screening of the antioxidant activity of some mediicinal plants. Korean J Food Sci Technol 36: 333-338. 
  14. Kim HJ, HwangBo MH, Lee JW, Im HG, Lee IS (2007) Antioxidant effects of ginseng powder on liver of benzo($\alpha$) pyrene-treated mice. Korean J Food Sci Technol 39: 217-221. 
  15. Kim MH, Jang SY, Lee YS (2006) Effect of dietary and genistein on lipid metabolism and antioxidant activity in hyperlipidemic male rats induced high fat diet. Korean J Nutr 39: 100-108. 
  16. Kim SK, Kim YG, Lee MK, Han JS, Lee JH, Lee HY (2000) Comparison of biological activity according to extracting solvents of four Acanthopanax root bark. Korean J Medicinal Crop Sci 8: 21-28. 
  17. Lee JS, Lee KH, Jeong JR (1999) Effects of extract of Pueraria radix on lipid metabolism in rats fed high fat diet. J Korean Soc Food Sci Nutr 28: 218-224. 
  18. Lovlin R, Cottle W, Pyke I, Kavanagh M, Belcastro AN (1987) The induces of free radical damage related to exercise intensity. European Journal of Applied Physiology & Occupational Physiology 6: 313-316. 
  19. Ministry of Health and Welfare (2006) Report on 2005 National health and nutrition survey (Nutrition survey). 
  20. Muller PH (1977) A fully enzymatic triglyceride determination. J Clin Chem Clin Biochem 15: 457-464. 
  21. Nam SM, Ham SS, Oh DH, Jung ME, Kang JJ, Chung CK (2002) Effects of Eucommmia ulmoides olivon ethanol extract on lipid metabolism and antioxidant enzyme activities of rats fed high fat diet. J Korean Soc Food Sci Nutr 31: 796-801. 
  22. Park JR, Kim SY, Chung EJ, Yoon S, Lee-Kim YC (2005) Effects of freeze-dried green vegetable extract on lipid profiles and antioxidant status in the rat. Korean J Nutr 38: 11-19. 
  23. Peglia ED, Valentine WN (1967) Studies on the quantitative qualitative characterization of erythrocytes glutathione peroxidase. Journal of Laboratory and Clinical Medicine 70: 158-169. 
  24. Richmond W (1976) Use of cholesterol oxidase for assay of total and free cholesterol in serum continuous flow analysis. Clin Chem 22: 1579-1588. 
  25. Rivero A, Monreal JI, Gil MJ (1994) Peroxisome enzyme modification and oxidative stress in rats by hypolipidemic and antinflammatory drugs. Res Esp Fisiol 50: 259-268. 
  26. Rosenfield L (1989) Lipoprotein anlysis. Arch Pathol Lab Med 113: 1101-1110. 
  27. Sarataho EP, Nyyssonen K, Salonen JT (1996) Increased oxidation resistance of atherogenic plasma lipoproteins at high vitamin E levels in non-vitamin E supplemented men. Atherosclerosis 124: 83-94. 
  28. Shin KH, Cho SY, Lee MK, Lee JS, Kim MJ (2004) Effects of Aralia elata, Acanthopanacis cortex and Ulmus davidiana water extracts on plasma biomarkers in streptozotocin-induced diabetic rats. J Korean Soc Food Sci Nutr 33: 1457-1462. 
  29. Shin WT, Lee KS (2004) The effect of Ogapi's ingestion exercise performance and SOD, MDA for 12 weeks. Korean Sport Res 15: 1309-1320. 
  30. Song YO, Chyun JR (2004) Effect of $\beta$-carotene supplementation on lipid peroxides and antioxidative enzyme activities in hyperlipidemic rats. Korean J Nutr 37: 771-779. 
  31. Sung TS, Son GM, Bae MJ, Choi C (1992) Effect of Acanthopanacis cortex boiling extract solutions on fat accumulation in the obese rats induced by high fat dietary. J Korean Soc Food Nutr 21: 9-16. 
  32. Szolomicki S, Samochowiec L, Wojcicki J, Drozdzik M (2000) The influence of active components of Eleutherococcus senticosus on cellular defence and physical fitness in man. Phytotherapy Res 14: 30-35. 
  33. Vagi K (1994) Lipid peroxides and related radicals in clinical medicine In Armstrong D. Eed, Free Radicals in Diagnostic Medicine. New York, Plenum Press. 1-15. 
  34. Vim JE, Chouse RW, Kim YS (1998) Effect of dietary counceling and HMG Co-A reductase inhibitor treatment on serum lipid levels in hyperlipidemic patients. Kor J Lipidology 8: 61-76. 
  35. Yoon JT, Seol IC, Kim DH, Kim SH (2001) An experimental study of antiallergic activity of medicinal acupunture solution of Acanthopanax senticosus. J Korean Acup Moxi Soci 18: 136-149. 
  36. Yun JS, Chung BH, Kim NY, Seong NS, Lee HY, Lee JR, Kim JD (2003) Screening of 94 plant species showing ACE inhibitory activity. Korean J Medicinal Crop Sci 11: 246-251. 
  37. Yun YP, Kang WS, Lee MY (1996) The antithrombotic effects of green tea catechins. J Food Hyg Safety 11: 77-82. 

이 논문을 인용한 문헌 (6)

  1. Seo, Sang-Hee ; Oh, Su-Young ; Lee, Ji-Seon ; Cho, Won-Kyung ; Kim, Tae-Soo ; Ma, Jin-Yeul 2011. "Effects of Soshiho-tang on Hydrogen Peroxide-induced Oxidative Damage in Hepatocytes" 대한한방내과학회지 = The journal of internal Korean medicine, 32(4): 487~496 
  2. Kim, Kyung-Sook ; Lee, Jin-Moo ; Lee, Chang-Hoon ; Jang, Jun-Bock ; Lee, Kyung-Sub 2011. "Effects of Acanthopanacis Cortex Radicis on the Apoptosis in HeLa cell and MCF-7 cell" 大韓韓方婦人科學會誌 = The Journal of Korean obstetrics & gynecology, 24(3): 14~27 
  3. Yu, Seok-Yeong ; Lee, Young-Jun ; Song, Ho-Seong ; Hong, Hee-Do ; Lim, Jeong-Ho ; Choi, Hyeon-Son ; Lee, Boo-Yong ; Kang, Suk-Nam ; Lee, Ok-Hwan 2012. "Antioxidant Effects and Nitrite Scavenging Ability of Extract from Acanthopanax cortex Shoot" 한국식품영양학회지 = The Korean journal of food and nutrition, 25(4): 793~799 
  4. Jin, So-Yeon ; Lee, Eun Ji ; Gil, Ga Young ; Joo, Shin Youn 2014. "Quality Characteristics and Antioxidant Activities of Cookies added Eleutherococcus sessiliflorus Leaf Powder" 東아시아食生活學會誌 = Journal of the East Asian Society of Dietary Life, 24(2): 234~241 
  5. Kim, Dae Hwan ; Choi, Mi-Ran ; Hong, Ji Eun ; Lee, Jae-Yong ; Lee, Soon Im ; Jung, Su Hwan ; Kim, Eun Ji 2014. "Effect of Mixture of Lactobacillus plantarum CECT 7527, 7528, and 7529 on Obesity and Lipid Metabolism in Rats Fed a High-fat Diet" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 43(10): 1484~1490 
  6. Lee, Jin Ho ; Kim, Min Jeong ; Lee, Jae Woong ; Kim, Me Riong ; Lee, In Hee ; Kim, Eun Jee 2015. "A Study on Standardization of Shinbaro Pharmacopuncture Using Herbal Medicines Identification Test and HPLC-DAD" The acupuncture = 대한침구의학회지, 32(2): 1~9 

DOI 인용 스타일