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논문 상세정보


Ulmus davidiana var. japonica is a deciduous tree used in traditional medicine. In this study, we examined the antioxidant and anti-inflammatory activity of extracts and compounds isolated from U. davidiana var. japonica stem barks for development of cosmetic phyto-materials. Phytochemical examination of the stem bark led to the isolation and characterization of three known compounds, (+)-catechin (1), (+)-catechin-7-O-${\beta}$-D-apiofuranoside (2), and procyanidin B3 ((+)-catechin-($4{\alpha}{\to}8$)-(+)-catechin) (3). Their bioactivities including antioxidant (DPPH ree radical scavenging assay) activity, anti-inflammatory (nitric oxide nhibition assay) were evaluated. Most of the crude extracts and isolates indicated significant antioxidant potential compared with BHT and ${\alpha}$-tocopherol as controls. Futhermore, all compounds showed higher inhibitory activities for NO production in Raw 264.7 cells than the L-NMMA using the positive control. Eespecially, (+)-catechin (1) and (+)-catechin-7-O-${\beta}$-D-apiofuranoside (2) which could inhibit more than 90% of the NO production at a concentration of 100 ${\mu}g/m{\ell}$, implying excellent anti-inflammatory activity.

참고문헌 (14)

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  4. Choi, Y. K., C. H. Lee, M. W. Lee, J. S. Kwon, G. S. Song, and Y. S. Kim. 2006. Effect of alcohol insoluble residues from stem and root barks of elm (Ulmus davidiana) on intestinal characteristics in rats. Food Science and Biotechnology 15: 380-384. 
  5. Green. L. C, D. A. Wagner, J. Glogowsky, P. L. Skipper, J. S. Wishnok, and S. R. Tannenbaum. 1982. Analysis of nitrate, nitrite and ($^{15}N$) nitrate in biological fluids. Analytical Biochemistry 126: 131-138. 
  6. Jung, H. J., H. J. Jeon, E. J. Lim, E. K. Ann, Y. S. Song, S. Lee, K. H. Shin, C. J. Lim, and E. H. Park. 2007. Anti-angiogenic activity of the methanol extract and its fractions of Ulmus davidiana var. japonica. Journal of Ethnopharmacology 112: 406-409. 
  7. Kim, Y. C, M. K. Lee, S. H. Sung, and S. H. Kim. 2007. Sesquiterpenes from Ulmus davidiana var. japonica with the inhibitory effects on lip-opolysaccharide-induced nitric oxide production. Fitoterapia 78: 196-199. 
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  9. Lee, J. C, K. Y. Lee, Y. O. Son, K. C. Choi, J. Kim, T. T. Truong, and Y. S. Jang. 2005. Plant-originated glycoprotein, G-120, inhibits the growth of MCF-7 cells and induces their apoptosis. Food and Chemical Toxicology 43: 961-968. 
  10. Lee, M. K., S. H. Sung, H. S. Lee, J. H. Cho, J. H. Kim, and Y. C. Kim. 2001. Lignan and ne-olignan glycosides from Ulmus davidiana var. japonica. Archives of Pharmacal Research 24:198-201 
  11. Lee, S. J. 1996. Korean folk medicine. Monographs series No. 3. Publishing center of Seoul National University, Seoul, South Korea. 
  12. Lee, Y. S., H. J. Park, H. S. Ryu, M. S. Chun, S. H. Kang, and H. S. Kim. 2007. Effects of elm bark (Ulmus davidiana var. japonica) extracts on the modulation of immunocompetence in Mice. Journal of Medicinal Food 10: 118-125. 
  13. Park, S., Y. M. Goo, and D. S. Na. 1996. Isolation and Structure elucidation of a catechin glycoside with phospholipase $A_2$ inhibiting activity from Ulmi cortex. Bulletin of the Korean Chemical Society 17: 101-103. 
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이 논문을 인용한 문헌 (1)

  1. Song, Jeong-Ho ; Jang, Kyung-Hwan ; Lim, Hyo-In ; Park, Wan-Geun ; Bae, Kwan-Ho 2011. "Variation of Samara, Seed, Germination and Growth Characteristics of Ulmus davidiana var. japonica Nakai Populations" 韓國林學會誌 = Journal of Korean Forest Society, 100(2): 226~231 


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