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제안 방법
- Here, we examined the ability of minocycline to promote motor recovery and reduce neuropathic pain in a rat model of SCI. Additionally we also evaluated whether minocycline attenuates microglial and astrocyte activation post SCI.
- number of experimental rats. Moreover, although we did not quantify the resulting lesion size secondary to SCI, we expect these measurements to be included in any subsequent investigations that quantify the extent of minocyclines neuroprotective effect. Despite these limitations, our results strongly suggest that minocycline exerts a significant neuroprotective effect after SCI, and may also promote post-SCI motor recovery
- The locomotor activity of the rats was assessed via semiquantitative method both before the operation, and at 1, 2, 4, 7, 10, 14, 20 and 28 days after surgery; Testing was performed by two trained observers under blind conditions and using BBB scales. The BBB locomotor rating has previously been described qualitatively with a 21-point scale by Basso et al*.
대상 데이터
- Fifteen male Sprague-Dawley rats (Orient Bio, Seoul, Korea) with body weights between 250-350 g were used. The rats were divided into three groups: sham control (n=5), hemisection control (n=5), and hemisection with minocycline (Hemi+Mino, n=5).
- The animals were anesthetized with a mixture of Tiletamine+Zo-lazepam (27.78 ㎎/㎏) and Xylazine (0.647 ㎎/㎏), before being mounted on a frame. A 3 cm midline incision was made on the back so the deep back muscles could be retracted to expose the lower thoracic vertebrae.
데이터처리
- Fifty percent probabilitythresholds of mechanical paw withdrawal were calculated75. Statistical analysis was performed by one-way ANOVA using SPSS (12.0 program).
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