계통발생 및 염기서열분석시 한우 송아지에서 중증의 급성 소 바이러스성 설사 바이러스 발생은 BVDV-2a에 속한 것으로 나타났고, BVDV-2 균주 890과는 독성 마커가 동일하였으며, 독성이 높은 것으로 분류되었다. 이들 BVDV 발생은 어린 송아지(20-40일령)에 주로 감염되었고, 임상증상으로 출혈성 설사, 침울, 식욕감퇴, 허약을 특징으로 하였다. 한우 송아지에서 고독성 BVDV-2의 발견은 역학조사, 진단 및 예방접종 전략에 중요한 영향을 내포한다.
Phylogenetic and nucleotide analysis revealed that severe acute bovine viral diarrhea virus (BVDV) outbreaks from Korean indigenous calves belonged to BVDV-2a, and were identical to those of the highly pathogenic BVDV-2 strain 890, with identical virulence markers and classified as highly virulent. These outbreaks affected young calves (20 and 40 day-old) and were characterized by hemorrhagic diarrhea, depression, anorexia, and weakness. The identification of the highly virulent BVDV-2 isolates among Korean indigenous calves may have important implications for epidemiological studies, diagnostic and immunization strategies.
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