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NTIS 바로가기大韓韓醫學會誌 = Journal of Korean Oriental Medicine, v.32 no.4, 2011년, pp.48 - 67
박영철 (대구가톨릭대학교 GLP 센터) , 박해모 (상지대학교 한의과대학 예방의학교실) , 이선동 (상지대학교 한의과대학 예방의학교실)
Objectives: There has been a lot of controversy about whether Korean traditional medicines cause drug-induced hepatotoxicity or not. However, this controversy has not been examined from a scientific approach, especially in terms of toxicology. Thus, this article for traditional Korean medicine-induc...
핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
임상적으로 또는 경험적으로 간독성을 유발하는 한약으로는 무엇이 있는가? | 임상적으로 또는 경험적으로 간독성을 유발하는 한약으로는 창이자, 천련자, 황단, 연분, 마황, 반하, 황금, 곡기생, 감초, 백선피, 황금, 현호색과 백굴채 등이 알려지고 있으나 정확한 기전은 명확하지 않다. 탕제에 의한 간독성의 대표적인 것은 소시호탕이다. | |
약인성 간독성이란 무엇인가? | 한약 및 양약을 비롯하여 모든 외인성 화학물질에 의해 유발되는 간손상을 약인성 간독성(drug-induced hepatotoxicity)이라고 한다. 미국의 경우에 약물에 의한 부작용이 전체 환자 중 9%에서 유발되는데 이중 약인성 간독성이 가장 많이 발생한다1). | |
소시호탕에 의한 간독성이 면역-매개 간염 또는 독성간염으로 추정이 애매한 이유는 무엇인가? | 소시호탕에 의한 간독성이 긴 잠복기를 가진다는 것은 면역학적인 과민반응(hypersenstivity reaction)에 의한 면역-매개 간염으로 추정된다. 그러나 과민반응일 경우에는 호산성백혈구(eosinophile)의 조직 침윤이 나타나지만 본 환례에서는 단핵구(mononuclear cell)의 염증성 침윤(inflammatory infiltration)이 확인되었다. 따라서 소시호탕에 의한 간독성은 면역-매개 간염 또는 독성간염으로 추정이 다소 애매한 측면이 있다. |
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