Red ginseng (RG, the extract of Panax ginseng Meyer) has various biological and psychological activities and may also alleviate fatigue-related disorders. The present study was undertaken to evaluate what kind of fatigue red ginseng alleviate. Animals were orally administered with 50, 100, 200, 400 ...
Red ginseng (RG, the extract of Panax ginseng Meyer) has various biological and psychological activities and may also alleviate fatigue-related disorders. The present study was undertaken to evaluate what kind of fatigue red ginseng alleviate. Animals were orally administered with 50, 100, 200, 400 mg/kg of RG for 7 days. Before experiments were performed. Physiological stress (swimming, rotarod, and wire test) are behavioral parameters used to represent physical fatigue. Restraint stress and electric field test to a certain degree, induce psychological fatigue in animals. Plasma concentration of lactate and corticosterone (CORT) were also measured after these behavioral assays. RG supplementation (100 mg/kg) increased movement duration and rearing frequency of restrainted mice in comparison with control. 100 and 200 mg/kg of RG increased swimming time in cold water ($8{\pm}4^{\circ}C$) while at 100 mg/kg, RG increased electric field crossing over frequencies. 50, 100 and 200 mg/kg RG prolonged running time on the rotarod and at 100 mg/kg, it increased balancing time on the wire. RG at those doses also reduced falling frequencies. RG supplementation decreased plasma CORT levels, which was increased by stress. Lactate levels were not significantly altered. These results suggest that RG supplementation can alleviate more the damages induced by psychological than physical fatigue.
Red ginseng (RG, the extract of Panax ginseng Meyer) has various biological and psychological activities and may also alleviate fatigue-related disorders. The present study was undertaken to evaluate what kind of fatigue red ginseng alleviate. Animals were orally administered with 50, 100, 200, 400 mg/kg of RG for 7 days. Before experiments were performed. Physiological stress (swimming, rotarod, and wire test) are behavioral parameters used to represent physical fatigue. Restraint stress and electric field test to a certain degree, induce psychological fatigue in animals. Plasma concentration of lactate and corticosterone (CORT) were also measured after these behavioral assays. RG supplementation (100 mg/kg) increased movement duration and rearing frequency of restrainted mice in comparison with control. 100 and 200 mg/kg of RG increased swimming time in cold water ($8{\pm}4^{\circ}C$) while at 100 mg/kg, RG increased electric field crossing over frequencies. 50, 100 and 200 mg/kg RG prolonged running time on the rotarod and at 100 mg/kg, it increased balancing time on the wire. RG at those doses also reduced falling frequencies. RG supplementation decreased plasma CORT levels, which was increased by stress. Lactate levels were not significantly altered. These results suggest that RG supplementation can alleviate more the damages induced by psychological than physical fatigue.
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제안 방법
The electric field test was conducted to evaluate overcoming of psychological stress. RG supplementation significantly increased crossing frequency over an electric field (Fig.
The electroshock test was performed in a Plexiglas box (42×27×15 cm) with a stainless steel grid floor.
The plasma CORT level was measured by a modified method [19] using HPLC system composed of SI-2 3001 pum, SI-2 3002 UV-Visible detector, SI-2 3004 column oven, separation (Shiseido, Tokyo, Japan), and column Capcell Pak C8 MG 120 (5 μm, 1.5 mm∅×250 mm).
They were housed in animal room which was maintained at temperature (22±2°C) and humidity (55±5%) under a 12/12-h light/dark cycle with lights on from 7:00 AM.
대상 데이터
The mice were forced to swim in cold water maintained at 8±2℃. The apparatus is a circular water tank (diameter, 150 cm; height, 50 cm) made of stainless steel. The pool was filled with water to a depth of 15 cm.
The observation apparatus consisted of nine plastic boxes (42×42) with a field bordered by 42-cm-high sidewalls.
데이터처리
Data were expressed as the mean±SEM. For statistical evaluation of data, one-way ANOVA was used. When statistically significant differences were found, NewmanKeul's test was used as a post-hoc test to determine the statistical differences between groups.
When statistically significant differences were found, NewmanKeul's test was used as a post-hoc test to determine the statistical differences between groups.
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