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NTIS 바로가기대한자기공명의과학회지 = Journal of the Korean society of magnetic resonance in medicine, v.15 no.2, 2011년, pp.110 - 122
엄민희 (연세대학교 의과대학 BK21 연세의과학사업단) , 박범희 (연세대학교 의과대학 BK21 연세의과학사업단) , 박해정 (연세대학교 의과대학 BK21 연세의과학사업단)
Purpose : The purpose of this study is to establish the method generating human brain anatomical connectivity from Korean children and evaluating the network topological properties using small-world network analysis. Materials and Methods : Using diffusion tensor images (DTI) and parcellation maps o...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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뇌연결망의 분석은 어떤 방법으로 가능해졌는가? | 이 연결망을 파악하는 것은 뇌인지과정과 뇌기능 이해의 고양이라는 신경과학의 목표를 달성하는데 중요 하다. 뇌연결망의 분석은 최근 비약적으로 발전된 기능적 자기공명뇌영상(functional Magnetic Resonance Imaging, fMRI), 확산텐서영상(Diffusion Tensor Imaging, DTI) 등의 뇌영상기법으로 가능해졌다(3-9). | |
기본상태신경망은 무엇을 나타낸 것인가? | 뇌의 연결망 지도 작성은 뇌파나 뇌자도, 기능자기공명뇌영상을 바탕으로 뉴런 간 활성수준의 시간적 동기화로 정의되는 기능 연결성 측면에서 꾸준히 이루어지고 있다(3-8). 특히, 휴식상태에서 뇌활성화를 보이는 영역들의 상관 관계를 나타낸, 이른바“기본상태신경망”이라는 연결망이 발견되었는데(5), 이 기본상태신경망은 뇌기능 고유의 구조적 특징을 반영한다고 알려져왔다(10). 기능자기공명뇌영상을 이용한 연구에서 휴식상태 기능 연결성은 영역 내 군집도가 높고 영역 간의 평균이동거리가 짧은, 매우 효율적인 작은세상연결망 (small world network)의 형태로 관측되었다(3-8). | |
확산텐서영상에 기반하여 한국 아동 집단의 해부학적 뇌연결성 지도를 확립하고 뇌신경망의 효율성을 평가하는 기법을 개발하고자 한 본 연구의 결과와 결론은? | 뇌신경망의 군집정도(clustering coefficient), 평균이동거리(characteristic path length), 전체/부분 연결망 효율성(global/local efficiency) 등 연결망 속성을 계산한 후 시각화 하였다. 결과 : 연결망 측면에서 한국 아동 집단의 뇌연결성이 작은세상속성을 가짐을 밝혔다. 또한 해부학적 뇌연결망 지도를 얻었는데 대뇌 반구 내의 연결성이 높게 나타남과 뇌간과 운동/감각 영역간에 많은 신경 연결이 집중되어 있음을 확인하였다. 결론 : 한국 아동 집단의 해부학적 뇌연결망 지도를 작성하는 방법론을 제시하여 뇌를 연결성 측면에서 이해하고 발달 장애와 성인 뇌신경망의 효율성을 평가할 수 있는 기본 도구를 확립하게되었다. |
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