[논문]Synthesis and Antiviral Evaluation of 7-O-Arylmethylquercetin Derivatives against SARS-associated Coronavirus (SCV) and Hepatitis C Virus (HCV)

Park, Hye Ri; Yoon, Hyunjun; Kim, Mi Kyoung; Lee, Sung Dae; Chong, Youhoon

doi:10.1007/s12272-012-0108-9

Synthesis and Antiviral Evaluation of 7-O-Arylmethylquercetin Derivatives against SARS-associated Coronavirus (SCV) and Hepatitis C Virus (HCV) 원문보기

Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, v.35 no.1, 2012년, pp.77 - 85

Park, Hye Ri (Department of Bioscience and Biotechnology, Bio) , Yoon, Hyunjun (Department of Bioscience and Biotechnology, Bio) , Kim, Mi Kyoung (Department of Bioscience and Biotechnology, Bio) , Lee, Sung Dae (Swine Science Division, National Institute of Animal Science, RDA) , Chong, Youhoon (Department of Bioscience and Biotechnology, Bio)

Abstract ▼ AI-Helper

Aryl diketoacid (ADK) is well known for antiviral activity which can be enhanced by introduction of an aromatic arylmethyl substituent. A natural flavonoid quercetin has a 3,5-dihydroxychromone pharmacophore which is in bioisosteric relationship with the 1,3-diketoacid moiety of the ADK. Thus, it was of our interest to test the antiviral activity of the quercetin derivatives with an arylmethyl group attached. In this study, we prepared a series of the 7-O-arylmethylquercetin derivatives with various aromatic substituents and evaluated their antiviral activity against the SARS-associated coronavirus (SARS-CoV, SCV) as well as hepatitis C virus (HCV). Single difference in the aromatic substituent fine-tuned the biological activity of the 7-O-arylmethylquercetin derivatives to result in two different classes of derivatives selectively active against SCV and HCV.

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Synthesis and Antiviral Evaluation of 7-O-Arylmethylquercetin Derivatives against SARS-associated Coronavirus (SCV) and Hepatitis C Virus (HCV) 원문보기

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Synthesis and Antiviral Evaluation of 7-O-Arylmethylquercetin Derivatives against SARS-associated Coronavirus (SCV) and Hepatitis C Virus (HCV) 원문보기

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