[논문]사람면역결핍바이러스 감염과 연관된 말초신경병증

이민환; 임영민; 변소영; 김지민; 김광국

사람면역결핍바이러스 감염과 연관된 말초신경병증
Peripheral Neuropathy Associated with Human Immunodeficiency Virus Infection 원문보기

대한임상신경생리학회지 = Korean journal of clinical neurophysiology, v.14 no.1, 2012년, pp.29 - 35

이민환 (울산대학교 의과대학 신경과학교실) , 임영민 (울산대학교 의과대학 신경과학교실) , 변소영 (울산대학교 의과대학 신경과학교실) , 김지민 (울산대학교 의과대학 신경과학교실) , 김광국 (울산대학교 의과대학 신경과학교실)

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Background: Peripheral neuropathy is the most frequent neurological complication in human immunodeficiency virus (HIV) infection, related with diverse etiologies including inflammation, opportunistic infection and side effects of medications. The purpose of the present study was to evaluate characteristics of HIV associated neuropathy according to the stage of HIV infection. Methods: In reviewing the medical records of HIV patients who underwent electrodiagnostic studies between 1997 and 2011, total 11 patients (all males; median age, 47 years; range, 28-71 years) with comorbid neuropathy were enrolled. Stage of HIV infection was categorized according to the Centers for Disease Control and Prevention (CDC) criteria. Classification of peripheral neuropathy was based on clinical and electrophysiological features. Results: Distal symmetric polyneuropathy was observed in 8 patients (72.7%), inflammatory demyelinating polyneuropathy in 2 patients (18.1%), and polyradiculopathy in 1 patient (9.1%). Median CD4+ T cell count was $123/mm^3$ (range, $8-540/mm^3$) and 7 patients (60%) had the most advanced HIV disease stage (CDC-C3). There was no neuropathy caused by CMV infection. Conclusions: Distal symmetric polyneuropathy was the most common type of neuropathy in HIV infection, but various forms of neuropathy such as inflammatory demyelinating polyneuropathy and polyradiculopathy were also present. HIV associated neuropathy is more frequently associated with advancing immunosuppression, although it can occur in all stages of HIV infection.

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참고문헌 (24)

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사람면역결핍바이러스 감염과 연관된 말초신경병증
Peripheral Neuropathy Associated with Human Immunodeficiency Virus Infection 원문보기

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사람면역결핍바이러스 감염과 연관된 말초신경병증 Peripheral Neuropathy Associated with Human Immunodeficiency Virus Infection 원문보기

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사람면역결핍바이러스 감염과 연관된 말초신경병증
Peripheral Neuropathy Associated with Human Immunodeficiency Virus Infection 원문보기