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NTIS 바로가기동의생리병리학회지 = Journal of physiology & pathology in Korean Medicine, v.26 no.3, 2012년, pp.273 - 280
박평범 (우석대학교 한의과대학 병리학교실) , 김민준 (우석대학교 한의과대학 병리학교실) , 신경호 (우석대학교 한의과대학 병리학교실) , 이광규 (우석대학교 한의과대학 병리학교실) , 이창현 (우석대학교 한의과대학 해부학교실) , 이상룡 (우석대학교 한의과대학 경혈학교실) , 하기태 (부산대학교 한의학전문대학원 응용의학부) , 정한솔 (부산대학교 한의학전문대학원 응용의학부)
Scutellaria baicalensis Georgi, which has been known to be able to clear away heat and remove dampness, was used for febrile disease. It is now clear that Advanced glycation end products (AGEs) play major roles in the pathogenesis of diabetic complications such as atherosclerosis. In this study, we ...
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핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
대사성질환의 발병률이 늘고 있는 이유는? | 생활패턴의 서구화로 인한 과도한 지방섭취, 운동부족, 스트레스 증가로 인한 대사성질환의 발병률이 크게 늘어나고 있다. 대사성 질환 가운데 당뇨는 꾸준히 증가하여 국민건강에 심각한 위해가 되고 있다1,2). | |
Hwanggeum에서 추출한 flavonoid 성분들의 효능은? | 이 가운데 주요한 약물인 Hwanggeum(HG)는 性味가 苦辛寒하며, 淸熱燥濕, 瀉火解毒, 止血安胎하는 효능을 지니고 있으며, 여러 염증성 질환에 응용되어 왔다9,10). 또한 많은 연구에서 HG는 항산화, 항균, 항염, 항종양, 항알레르기의 효능을 지니는 것으로 보고되었으며27,28), HG에서 추출한 flavonoid 성분들의 항염, 항암, 항균, 항바이러스, 항혈전의 효능들이 보고되고 있다29). 이에 본 연구에서는 황금탕의 주요 약물인 HG의 물 추출물이 AGE로 유발한 염증반응을 얼마나 효과적으로 차단할 수 있는지 관찰하였다. | |
당뇨로 인한 죽상동맥경화증의 발병은 무엇으로 인해 더욱 심화되는가? | 오랜 기간 당뇨를앓게 되면 심혈관질환, 만성신장질환, 실명을 유도할 수 있는 망막손상, 신경손상, 혈관손상으로 인한 상처치유의 지연 등의 심각한 합병증이 발생하게 되는데 이러한 합병증에는 동맥경화증이 중추적 역할을 담당 하고 있다. 당뇨로 인한 죽상동맥경화증의 발병은 지속되는 고혈당, 고지혈증13,14), 및 동맥의 만성염증반응, 산화와 관련되어지는 당화종말산물의 축적으로 더욱 심화되는 것으로 알려져 있다15,16). |
Hu, F.B., Manson, J.E., Stampfer, M.J., Colditz, G., Liu, S., Solomon, C.G., Willett, W.C. Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med. 345: 790-797, 2001.
Zimmet, P., Alberti, K.G., Shaw, J. Global and societal implications of the diabetes epidemic. Nature. 414: 782-787, 2001.
Kahn, S.E., Hull, R.L., Utzschneider, K.M. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 444: 840-846, 2006.
Kathryn, E., Wellen, Gokhan, S. Hotamisligil. Inflammation, stress, and diabetes. J Clin Invest. 115(5):1111-1119, 2005.
Schmidt, M.I., Saad, M.J.A., Duncan, B.B. Subclinical inflammation and obesity, diabetes and related disorders. Drug Discovery Today: Disease Mechanisms. 3(3):307-312, 2005.
Harja, E., Bu, D.X., Hudson, B., Chang, J.S., Shen, X., Hallam, K., et al. Vascular and inflammatory stress mediate atherosclerosis via RAGE and its ligands in apoE-/-mice. J Clin Invest. 118: 183-191, 2008.
Yamamoto, Y., Kato, I., Doi, T., Yonekura, H., Ohashi, S., Takeuchi, M., Watanabe, T., Yamagishi, S., Sakurai, S., Takasawa, S., Okamoto, H., Yamamoto, H. Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice. J Clin Invest 108: 261-268, 2001.
Jeong, S.H., Lee, K.G., Lee, C.H., Lee, S.R., Kim, J.E., Ha, K.T., Shin, S.W., Jeong, H.S. Effects of Hwanggeum-tang water extract on the expression of pro-inflammatory response elicited by advanced glycation end products in THP-1 cells. Korean J. Oriental Physology & Pathology. 26(2):147-154, 2012.
전국한의과대학본초학교수 공편. 本草學, 서울, 도서출판 영 림사. pp 178-179, 1992.
楊艶, 梁日欣, 楊濱, 王怡薇, 王嵐, 王彦禮. ?芩 等5?中藥提 物的抗脂 質過?化作用?究. 中國實驗方劑學雜誌. 15(9):46-48, 2009.
Mosmann, T. Rapid colorimetric assay for cellular growth and survival application to proliferation and cytotoxic assays. J Immunol Methods. 65: 55-63, 1983.
Wild, S., Roglic, G., Green, A., Sicree, R., King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care, 27(5):1047-1053, 2004.
Ruderman, N., Williamson, J.R., Brownlee, M. Glucose and diabetic vascular disease. FASEB J. 6: 2905-2914, 1992.
Pugliese, G., Tilton, R.G., Williamson, J.R. Glucose-induced metabolic imbalances in the pathogenesis of diabetic vascular disease. Diabete Metab Rev. 7: 35-59, 1991.
Brownlee, M. Biochemistry and molecular cell biology of diabetic complications. Nature. 414: 813-820, 2001.
Brownlee, M., Cerami, A., Vlassara, H. Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. N Engl J Med. 318: 1315-1321, 1988.
Bucala, R., Cerami, A., Vlassara, H. Advanced glycosylation end products in diabetic complications. Diabetes Rev. 3: 258-268, 1995.
Vlassara, H. Recent progress in advanced Nglycation end products and diabetic complications. Diabetes. 46(2):S19-S25, 1997.
Bierhaus, A., Hofmann, M.A., Ziegler, R., Nawroth, P. AGEs and their interaction with AGE-receptors in vascular disease and diabetes mellitus. I. The AGE concept. Cardiovasc Res. 37: 586-600, 1998.
Chappy, O., Dosquet, C., Wautier, M.P., Wautier, J.L. Advanced glycation end products, oxidant stress and vascular lesions. Eur J Clin Invest. 27: 97-108, 1997.
White, M.F. The insulin signaling system and the IRS protein. Diabetologia. 40: S2-S17, 1997.
Saltiel, A.R., Pessin, J.E. Insulin signaling pathway in time and space. Trends Cell Biol. 12: 65-71, 2002.
Yin, M.J., Yamamoto, Y., Gaynor, R.B. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature. 396: 77-80, 1998.
Aguirre, V., Uchida, T., Yenush, L., Davis, R., White, M.F. The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J. Biol. Chem. 275: 9047-9054, 2000.
Ozcan, U., Cao, Q., Yilmaz, E., Lee, A.H., Iwakoshi, N.N., Ozdelen, E., et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science. 306: 457-461, 2004.
Nakatani, Y., Kaneto, H., Kawamori, D., Yoshiuchi, K., Hatazaki, M., Matsuoka, T., et al. Involvement of endoplasmic reticulum stress in insulin resistance and diabetes. J. Biol. Chem. 280: 847-851, 2005.
Martin, J., Dusek, J. The Baikal scullcap (Scutellaria baicalensis Georgi)-a potential source of new drugs. Ceska Slov Farm. 51(6):277-283, 2002.
Broncel, M. Antiatherosclerotic properties of flavones from the roots of Scutellaria baicalensis Georgi. Wiad Lek. 60(5-6):294-297, 2007.
Kowalczyk, E., Krzesinski, P., Kura, M., Niedworok, J., Kowalski, J., Bllaszczyk, J. Pharmacological effects of flavonoids from scutellaria baicalensis. Przegl Lek. 63(2):95-96, 2006.
Ames, N.B., Shigenaga, M.K., Hagen, T.M. Oxidants, antioxidants and the degenerative disease of aging. Proc. Natl. Acad. Sci. 90: 7915-7922, 1993.
Cerutti, P.A., Trump, B.F. Inflammation and oxidative stress in carcinogenesis. Cancer Cells. 3: 1-7, 1991.
Blois, M.S. Antioxidant determination by the use a stable free radicals. Nature. 26: 1191-1204, 1958.
Hou, Y.C., Janczuk, A., Wang, P.G. Current trends in the development of nitric oxide donors. Curr. Pharm. Des. 5(6):417-471, 1999.
Tylor, B.S., Kion, Y.M., Wang, Q.I., Sharpio, R.A., Billiar, T.R., Geller, D.A. Nitric oxide down regulates hepatocyte-inducible nitric oxide synthase gene expression. Arch. Surg. 1(32):1177-1182, 1997.
Xie, Q.W., Kashiwabara, Y., Nathan, C. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J Biol Chem. 269: 4705-4708, 1994.
Hiroki, S., Masao, K., Eriko, T., Michiko, S., Chieko, K., Shingo, Y., et al. Inducible nitric oxide synthase plays a role in LPS-induced hyperglycemia and insulin resistance. Am J Physiol Endocrinol Metab. 282: 386-394, 2002.
Esaki, T., Hayashi, T., Muto, E., Yamada, K., Kuzuya, M., Iguchi, A. Expression of inducible nitric oxide systhase in T lymphocytes and macrophages of cholesterol-fed rabbits. Atherosclerosis. 128: 39-46, 1997.
Schleicher, E.D., Wagner, E., Nerlich, A.G. Increased accumulation of glycoxidation product $N{\varepsilon}$ -(carboxymethyl)lysine in human tissue in diabetes and aging. J Clin Invest. 99: 457-468, 1997.
Maxwell, S.R.J. Prospects for the use of antioxidant therapies. Drugs. 49: 345-361, 1995.
Halliwell, B., Gutteridege, J.M.C. Free radicals in Biology and Medicine, 2nd ed. Oxford, Clarendon Press. pp 416-494, 1989.
Gu, L., Tseng, S.C., Rollins, B.J. Monocyte chemoattractant protein-1. Chem Immunol. 72: 7-29, 1999.
Langenbach, R., Morham, S.G., Tiano, H.F., Loftin, C.D., Ghanayem, B.I., Chulada, P.C., et al. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell. 83: 483-492, 1995.
Inoue, H., Umesono, K., Nishimori, T., Hirata, T., Tanabe, T. Glucocorticoid-mediated suppression of the promotor activity of the cyclooxygenase-2 gene is modulated by expression of its receptor in vascular endothelial cells. Biochem Bioph Res Commun. 254: 292-298, 1999.
Tabatabaie, T., Vasquez-Weldon, A., Moore, D.R., Kotake, Y. Free Radicals and the Pathogenesis of Type 1 Diabetes: beta-Cell Cytokine-Mediated Free Radical Generation Via Cyclooxygenase-2. Diabetes. 52: 1994-1999, 2003.
Skata, N., Uesugi, N., Takebayashi, S., Nagai, R., Jono, T., Horiuchi, S., et al. Glycoxidation and lipid peroxidation of low-density lipoprotein can synergistically enhance atherogenesis. Cardiovasc Res 49: 466-475, 2001.
Imani, F., Horii, Y., Suthanthiran, M., Skolnik, E.Y., Makita, Z., Sharma, V., et al. Advanced glycosylation endproduct-specific receptors on human and rat T-lymphocytes mediate synthesis of interferon- ${\gamma}$ . J Exp Med. 178: 2165-2172, 1993.
Lander, H.M., Tauras, J.M., Ogiste, J.S., Hori, O., Moss, R.A., Schmidt, A.M. Activation of the receptor for advanced glycation end products triggers a p21ras-dependent mitogen-activated protein kinase pathway regulated by oxidant stress. J Biol Chem. 272: 17810-17814, 1997.
Yeh, C.H., Sturgis, L., Haidacher, J., Zhang, X.N., Sherwood, S.J., Bjercke, R.J., et al. Requirement for p38 and p44/p42 mitogen-activated protein kinases in RAGE-mediated nuclear factor- ${\kappa}B$ transcriptional activation and cytokine secretion. Diabetes. 50: 1495-1504, 2001.
Baeuerle, P.A., Baltimore, D. NF- ${\kappa}B$ : ten years after. Cell. 87: 13-20, 1996.
Barnes, P.J., Karin, M. Nuclear Factor- ${\kappa}B$ -a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med. 336: 1066-1071, 1997.
Jacobs, M.D., Harrison, S.C. Structure of an $I{\kappa}B{\alpha}/NF-{\kappa}B$ Complex. Cell. 95(6):749-758, 1998.
Bierhaus, A., Schiekofer, S., Schwaninger, M., Andrassy, M., Humpert, Per, M., Chen, J., et al. Diabetes-Associated Sustained Activation of the Transcription Factor Nuclear Factor-B. Diabete. 50: 2792-2808, 2001.
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