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NTIS 바로가기Development & reproduction = 발생과 생식, v.16 no.2, 2012년, pp.129 - 135
유상미 (중앙대학교 자연과학대학 생명과학과) , 이강석 (중앙대학교 자연과학대학 생명과학과) , 배지현 (중앙대학교 약학대학 약학부)
Previously, we identified that the overexpression of IEX-1 induces apoptosis in ovarian cancer cells. Herein we report a new binding partner of IEX-1, CATHEPSIN B, as a lysosomal enzyme which contributes to the various apoptotic signaling in tumor cells. To investigate how IEX-1 regulates cellular s...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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IEX-1의 발현증가는 무엇과 관련이 있는가? | , 1998). IEX-1의 발현증가는 keratinocytes와 HeLa 세포의 성장률 증가와 관련이 있으며(Arlt et al., 2001; Schilling et al. | |
IEX-1가 세포 생장신호의 억제 효과를 나타내는 것에 대한 보고의 예시로는 무엇이 있는가? | 이와는 다르게, 세포 생장신호의 억제 효과를 나타내는 것이 보고되었다. 예를 들어, IEX-1 단백질은 TNF-α 신호전달 체계억제와 PI3K (phoshatidylinositol 3-kinase)와 AKT의 활성화 억제, 그리고 anti-apoptotic BCL-2 family member인 MCL-1의 발현 억제를 유도하는 것으로 보고되었다(Osawa et al., 2003; Schilling et al. | |
Immediate early gene X-1은 어떻게 알려졌는가? | Immediate early gene X-1(IEX-1, 또는 Dif2, murine orthologs gly96, PRG1)은 세포의 성장과 세포사멸(apoptosis) 을 조절하는 중요한 단백질로 알려져 있으며(Charles et al., 1993; Kumar et al., 2004), 방사선조사(X-, UV-irradiation), stress 혹은 성장인자(epidermal growth factor), inflammatory stimuli(lipopolysaccharide, ceramide) 등의 요인에 의해 초기에 발현이 조절되어지는 것으로 알려져 있다(Kobayashi et al., 1998; Kondratyev et al., 1996). 또한 steroid hormones (1α, 25-dihydroxyvitamin D3), p53의 과다 발현에 의해 IEX-1의 발현양이 감소하는 것으로 알려져 있다(Im et al., 2002; Kobayashi et al. |
Arlt A, Grobe O, Sieke A, Kruse ML, Folsch UR, Schmidt WE, Schafer H (2001). Expression of the NF-kappa B target gene IEX-1 (p22/PRG1) does not prevent cell death but instead triggers apoptosis in Hela cells. Oncogene 20:69-76.
Arlt A, Kruse ML, Breitenbroich M, Gehrz A, Koc B, Minkenberg J, Folsch UR, Schafer H. (2003). The early response gene IEX-1 attenuates NF-kappaB activation in 293 cells, a possible counter-regulatory process leading to enhanced cell death. Oncogene 22: 3343-3351.
Arlt A, Rosenstiel P, Kruse ML, Grohmann F, Minkenberg J, Perkins ND, Folsch UR, Schreiber S, Schafer H (2008). IEX-1 directly interferes with RelA/p65 dependent transactivation and regulation of apoptosis. Biochim Biophys Acta 1783:941-952.
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Kruse ML, Arlt A, Sieke A, Grohmann F, Grossmann M, Minkenberg J, Folsch UR, Schafer H (2005). Immediate early gene X1 (IEX-1) is organized in subnuclear structures and partially co-localizes with promyelocytic leukemia protein in HeLa cells. J Biol Chem 280: 24849-24856.
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Schilling D, Pittelkow MR, Kumar R (2001). IEX-1, an immediate early gene, increases the rate of apoptosis in keratinocytes. Oncogene 20:7992-7997.
Shen L, Guo J, Santos-Berrios C, Wu MX (2006). Distinct domains for anti- and pro-apoptotic activities of IEX-1. J Biol Chem 281:15304-15311.
Stoka V, Turk B, Schendel SL, Kim TH, Cirman T, Snipas SJ, Ellerby LM, Bredesen D, Freeze H, Abrahamson M, Bromme D, Krajewski S, Reed JC, Yin XM, Turk V, Salvesen GS (2001). Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route. J Biol Chem 276:3149-3157.
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Yoon S, Ha HJ, Kim YH, Won M, Park M, Ko JJ, Lee K, Bae J (2009). IEX-1-induced cell death requires BIM and is modulated by MCL-1. Biochem Biophys Res Commun 382:400-404.
Yoon S, Na SY, Kim HM, Lee K, Bae J (2010) Mutural activities of IEX-1 and MCL-1 on the apoptosis of ovarian cancer cells. Develpoment and Reproduction 14:83-89.
Zhang Y, Finegold MJ, Porteu F, Kanteti P, Wu MX (2003). Development of T-cell lymphomas in Emu-IEX-1 mice. Oncogene 22:6845-6851.
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