최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기Journal of ginseng research = 高麗人參學會誌, v.37 no.3, 2013년, pp.324 - 331
Choi, Sun-Hye (Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine and Bio) , Lee, Byung-Hwan (Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine and Bio) , Kim, Hyeon-Joong (Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine and Bio) , Jung, Seok-Won (Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine and Bio) , Hwang, Sung-Hee (Department of Pharmaceutical Engineering, Sangji University) , Nah, Seung-Yeol (Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine and Bio)
Channels formed by the co-assembly of the KCNQ1 subunit and the mink (KCNE1) subunit underline the slowly activating delayed rectifier
* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.
1 Wang Q Curran ME Splawski I Burn TC Millholland JM VanRaay TJ Shen J Timothy KW Vincent GM de Jager T et al. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat Genet 1996 12 17 23 8528244
2 Barhanin J Lesage F Guillemare E Fink M Lazdunski M Romey G K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current. Nature 1996 384 78 80 10.1038/384078a0 8900282
3 Sanguinetti MC Curran ME Zou A Shen J Spector PS Atkinson DL Keating MT Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. Nature 1996 384 80 83 10.1038/384080a0 8900283
4 Pusch M Magrassi R Wollnik B Conti F Activation and inactivation of homomeric KvLQT1 potassium channels. Biophys J 1998 75 785 792 10.1016/S0006-3495(98)77568-X 9675180
5 Seebohm G Scherer CR Busch AE Lerche C Identification of specific pore residues mediating KCNQ1 inactivation. A novel mechanism for long QT syndrome. J Biol Chem 2001 276 13600 13605 11278406
6 Neyroud N Tesson F Denjoy I Leibovici M Donger C Barhanin J Faure S Gary F Coumel P Petit C et al. A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome. Nat Genet 1997 15 186 189 10.1038/ng0297-186 9020846
7 Mall M Bleich M Schurlein M Kuhr J Seydewitz HH Brandis M Greger R Kunzelmann K Cholinergic ion secretion in human colon requires coactivation by cAMP. Am J Physiol 1998 275 6 Pt 1 G1274 G1281 9843763
8 Grahammer F Herling AW Lang HJ Schmitt-Graff A Wittekindt OH Nitschke R Bleich M Barhanin J Warth R The cardiac K + channel KCNQ1 is essential for gastric acid secretion. Gastroenterology 2001 120 1363 1371 10.1053/gast.2001.24053 11313306
9 Snyders DJ Structure and function of cardiac potassium channels. Cardiovasc Res 1999 42 377 390 10.1016/S0008-6363(99)00071-1 10533574
10 Cheng JH Kodama I Two components of delayed rectifier K + current in heart: molecular basis, functional diversity, and contribution to repolarization. Acta Pharmacol Sin 2004 25 137 145 14769199
11 Sanguinetti MC Dysfunction of delayed rectifier potassium channels in an inherited cardiac arrhythmia. Ann N Y Acad Sci 1999 868 406 413 10.1111/j.1749-6632.1999.tb11302.x 10414310
12 Roden DM Balser JR George AL Jr Anderson ME Cardiac ion channels. Annu Rev Physiol 2002 64 431 475 10.1146/annurev.physiol.64.083101.145105 11826275
13 Tristani-Firouzi M Sanguinetti MC Structural determinants and biophysical properties of HERG and KCNQ1 channel gating. J Mol Cell Cardiol 2003 35 27 35 10.1016/S0022-2828(02)00286-9 12623297
14 Robbins J KCNQ potassium channels: physiology, pathophysiology, and pharmacology. Pharmacol Ther 2001 90 1 19 10.1016/S0163-7258(01)00116-4 11448722
15 Nah SY Ginseng: recent advances and trends. Korea J Ginseng Sci 1997 21 1 12
16 Attele AS Wu JA Yuan CS Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol 1999 58 1685 1693 10.1016/S0006-2952(99)00212-9 10571242
17 Chen X Gillis CN Moalli R Vascular effects of ginsenosides in vitro. Br J Pharmacol 1984 82 485 491 10.1111/j.1476-5381.1984.tb10784.x 6587929
18 Chen X Cardiovascular protection by ginsenosides and their nitric oxide releasing action. Clin Exp Pharmacol Physiol 1996 23 728 732 10.1111/j.1440-1681.1996.tb01767.x 8886498
19 Bai CX Sunami A Namiki T Sawanobori T Furukawa T Electrophysiological effects of ginseng and ginsenoside Re in guinea pig ventricular myocytes. Eur J Pharmacol 2003 476 35 44 10.1016/S0014-2999(03)02174-5 12969747
20 Furukawa T Bai CX Kaihara A Ozaki E Kawano T Nakaya Y Awais M Sato M Umezawa Y Kurokawa J Ginsenoside Re, a main phytosterol of Panax ginseng, activates cardiac potassium channels via a nongenomic pathway of sex hormones. Mol Pharmacol 2006 70 1916 1924 10.1124/mol.106.028134 16985185
21 Choi SH Shin TJ Lee BH Chu DH Choe H Pyo MK Hwang SH Kim BR Lee SM Lee JH et al. Ginsenoside Rg3 activates human KCNQ1 K + channel currents through interacting with the K318 and V319 residues: a role of KCNE1 subunit. Eur J Pharmacol 2010 637 138 147 10.1016/j.ejphar.2010.04.001 20399767
23 Hasegawa H Suzuki R Nagaoka T Tezuka Y Kadota S Saiki I Prevention of growth and metastasis of murine melanoma through enhanced natural-killer cytotoxicity by fatty acid-conjugate of protopanaxatriol. Biol Pharm Bull 2002 25 861 866 10.1248/bpb.25.861 12132658
24 Akao T Kanaoka M Kobashi K Appearance of compound K, a major metabolite of ginsenoside Rb1 by intestinal bacteria, in rat plasma after oral administration: measurement of compound K by enzyme immunoassay. Biol Pharm Bull 1998 21 245 249 10.1248/bpb.21.245 9556154
25 Bae EA Park SY Kim DH Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol Pharm Bull 2000 23 1481 1485 10.1248/bpb.23.1481 11145182
26 Tawab MA Bahr U Karas M Wurglics M Schubert-Zsilavecz M Degradation of ginsenosides in humans after oral administration. Drug Metab Dispos 2003 31 1065 1071 10.1124/dmd.31.8.1065 12867496
27 Lee JH Jeong SM Kim JH Lee BH Yoon IS Lee JH Choi SH Kim DH Rhim H Kim SS et al. Characteristics of ginsenoside Rg3-mediated brain Na + current inhibition. Mol Pharmacol 2005 68 1114 1126 10.1124/mol.105.015115 16014805
28 Wakabayashi C Hasegawa H Murata J Saiki I In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration. Oncol Res 1997 9 411 417 9436194
29 Wang CZ Du GJ Zhang Z Wen XD Calway T Zhen Z Musch MW Bissonnette M Chang EB Yuan CS Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancer. Int J Oncol 2012 40 1970 1976 22426808
30 Splawski I Tristani-Firouzi M Lehmann MH Sanguinetti MC Keating MT Mutations in the hminK gene cause long QT syndrome and suppress IKs function. Nat Genet 1997 17 338 340 10.1038/ng1197-338 9354802
31 Seebohm G Pusch M Chen J Sanguinetti MC Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels. Circ Res 2003 93 941 947 10.1161/01.RES.0000102866.67863.2B 14576198
32 Salata JJ Jurkiewicz NK Wang J Evans BE Orme HT Sanguinetti MC A novel benzodiazepine that activates cardiac slow delayed rectifier K + currents. Mol Pharmacol 1998 54 220 230 9658209
33 Lee JH Jeong SM Kim JH Lee BH Yoon IS Lee JH Choi SH Lee SM Park YS Lee JH et al. Effects of ginsenosides and their metabolites on voltage-dependent Ca(2+) channel subtypes. Mol Cells 2006 21 52 62 16511347
34 Kim JH Hong YH Lee JH Kim DH Nam G Jeong SM Lee BH Lee SM Nah SY A role for the carbohydrate portion of ginsenoside Rg3 in Na + channel inhibition. Mol Cells 2005 19 137 142 15750351
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
오픈액세스 학술지에 출판된 논문
※ AI-Helper는 부적절한 답변을 할 수 있습니다.