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NTIS 바로가기한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, v.43 no.2, 2014년, pp.293 - 299
김주희 (이화여자대학교 바이오푸드네트워크) , 김지연 (서울과학기술대학교 식품공학과) , 곽진숙 (주식회사 바이오푸드씨알오) , 백주은 (주식회사 바이오푸드씨알오) , 정세원 (이화여자대학교 바이오푸드네트워크) , 권오란 (이화여자대학교 바이오푸드네트워크)
Although the functional ingredient has been evaluated based on scientific evidence by the Ministry of Food and Drug Safety (MFDS), the levels of scientific evidence and consistency of the results might vary according to the emerging data. Therefore, a periodic re-evaluation may be needed in some fun...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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글루코사민의 섭취는 관절에 어떤 도움을 주는가? | 글루코사민(2-amio-2-deoxy-D-glucose)은 아미노산과 당의 결합물인 아미노당의 하나로 연골을 구성하는 필수성분으로 알려져 있으며(1), 글루코사민의 섭취는 골관절염의 통증을 완화하고 연골을 재생시켜 관절건강에 도움이 된다고 보고되어 2004년「건강기능식품에 관한 법률」시행과 동시에 건강기능식품공전에 글루코사민 함유제품으로 등재되었다(2). 글루코사민은 2004년부터 2006년까지 진행된 식품의약품안전처의 고시형 건강기능식품 재평가 사업에서 기능성 내용이 문헌 검토만으로도 충분하게 과학적 근거가 있음이 확인되었으며, 재평가 사업을 통해 수행된 인체적용시험에서도 기능성이 확인되어 글루코사민 섭취량 1. | |
글루코사민이란 무엇인가? | 글루코사민(2-amio-2-deoxy-D-glucose)은 아미노산과 당의 결합물인 아미노당의 하나로 연골을 구성하는 필수성분으로 알려져 있으며(1), 글루코사민의 섭취는 골관절염의 통증을 완화하고 연골을 재생시켜 관절건강에 도움이 된다고 보고되어 2004년「건강기능식품에 관한 법률」시행과 동시에 건강기능식품공전에 글루코사민 함유제품으로 등재되었다(2). 글루코사민은 2004년부터 2006년까지 진행된 식품의약품안전처의 고시형 건강기능식품 재평가 사업에서 기능성 내용이 문헌 검토만으로도 충분하게 과학적 근거가 있음이 확인되었으며, 재평가 사업을 통해 수행된 인체적용시험에서도 기능성이 확인되어 글루코사민 섭취량 1. | |
근거중심평가방법의 장점은 무엇인가? | 건강기능식품의 기능성은 근거중심평가방법에 의해 평가 시점에서의 모든 연구결과들을 종합하여 평가한다. 체계적 고찰방법이라고도 불리는 이 방법은 많은 양의 연구결과들을 연구자의 편견이나 견해를 최대한 배제하여 좀 더 객관적이고 정확하게 현재까지의 연구결과들을 종합할 수 있다는 장점이 있다. 하지만 체계적 고찰방법에 의해 평가되는 경우에도 평가된 시점 이후 새로운 과학적 증거들이 보고된다면 이를 기반으로 한 재평가가 다시 수행되어야 할 것이다. |
Specific functional food glucosamine. Ministry of Food and Drug Safety, Korea. www.foodnara.go.kr/hfoodi/industry/ (accessed May 2013).
Health Functional Food Code. 2004. Ministry of Food and Drug Safety, Korea.
Park TS. 2006. Report on "Functionality Reevaluation for Fatigue Recovery, Bone Metabolism, Skin Beauty Improvement, and Body Weight Reduction of Health Functional Foods". Korea Food and Drug Administration. No. 06052-053. rnd.mfds.go.kr (accessed May 2013).
Bae SC. 2009. Report on "Effect of glucosamine and chondroitin in osteoarthritis". National Evidence-based Healthcare Collaboration Agency. www.neca.re.kr/center/researcher/ report_list.jsp?boardNoGA (accessed May 2013).
Food and Drug Administration. Guidance compliance regulatory information. www.fda.gov/Food/GuidanceRegulation/ GuidanceDocumentsRegulatoryInformation/LabelingNutriti on/ucm073332.htm (accessed May 2013).
Codex Guidelines for use of nutrition and health claims. CAC/GL 23-1997, Rev. 1-2004.
Korea Food and Drug Administration. Regulation for evaluation on efficacy of health functional food. www.foodnara. go.kr/hfoodi/industry/ (accessed May 2013).
Clegg, DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM, Bradley JD, Bingham CO, Weisman MH, Jackson CG, Lane NE, Cush JJ, Moreland LW, Schumacher R, Oddis CV, Wolfe F, Molitor JA, Yocum DE, Schnitzer TJ, Furst DE, Sawitzke AD, Shi H, Brandt KD, Moskowitz RW, Williamns J. 2006. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 354: 795-808.
Reginster JY, Deroisy R, Rovati LC, Lee RL, Lejeune E, Bruyere O, Giacovelli G, Henrotin Y, Dacre JE, Gossett C. 2001. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet 357: 251-256.
Pavelka K, Gatterova J, Olejarova M, Machacek S, Giacovelli G, Rovati LC. 2002. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med 162: 2113-2123.
Frestedt JL, Walsh M, Kuskowski MA, Zenk JL. 2008. A natural mineral supplement provides relief from knee osteoarthritis symptoms: a randomized controlled pilot trial. Nutr J 7: 9.
Giordano N, Fioravanti A, Papakostas P, Montella A, Giorgi G, Nuti R. 2009. The efficacy and tolerability of glucosamine sulfate in the treatment of knee osteoarthritis: A randomized, double-blind, placebo-controlled trial. Curr Ther Res 70: 185-196.
Herrero-Beaumont G, Ivorra JA, Del Carmen Trabado M, Blanco FJ, Benito P, Martin-Mola E, Paulino J, Marenco JL, Porto A, Laffon A, Araujo D, Figueroa M, Branco J. 2007. Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebocontrolled study using acetaminophen as a side comparator. Arthritis Rheum 56: 555-567.
Houpt JB, McMillan R, Wein C, Paget-Dellio SD. 1999. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. J Rheumatol 26: 2423-2430.
Petersen SG, Saxne T, Heinegard D, Hansen M, Holm L, Koskinen S, Stordal C, Christensen H, Aagaard P, Kjaer M. 2010. Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training. Osteoarthritis Cartilage 18: 34-40.
Noack W, Fischer M, Forster KK, Rovatis LC, Setnikar I. 1994. Glucosamine sulfate in osteoarthritis of the knee. Osteoarthritis Cartilage 2: 51-59.
Braham R, Dawson B, Goodman C. 2003. The effect of glucosamine supplementation on people experiencing regular knee pain. Br J Sports Med 37: 45-49.
Muller-Fassbender H, Bach GL, Haase W, Rovati LC, Setnikar I. 1994. Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee. Osteoarthritis Cartilage 2: 61-69.
Lee DY, Moon HS, Cho KH, Cheon JE. 2001. Effect of glucosamine for knee osteoarthritis. J Korean Knee Soc 13: 130-136.
Marti-Bonmati L, Sanz-Requena R, Rodrigo JL, Alberich- Bayarri A, Carot JM. 2009. Glucosamine sulfate effect on the degenerated patellar cartilage: preliminary findings by pharmacokinetic magnetic resonance modeling. Eur Radiol 19: 1512-1518.
Qiu GX, Gao SN, Giacovelli G, Rovati L, Setnikar I. 1998. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis. Arzneimittelforschung 48: 469-474.
Lopes Vaz A. 1982. Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthrosis of the knee in out-patients. Curr Med Res Opin 8: 145-149.
Pujalte JM, Llavore EP, Ylescupidez F. 1980. Double-blind clinical evaluation of oral glucosamine sulphate in the basic treatment of osteoarthrosis. Curr Med Res Opin 7: 110-114.
Drovanti A, Bignamini AA, Rovati AL. 1980. Therapeutic activity of oral glucosamine sulfate in osteoarthrosis: a placebo- controlled double-blind investigation. Clin Ther 3: 260-272.
Usha PR, Naidu MUR. 2004. Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clin Drug Investig 24: 353-363.
Zenk JL, Helmer TR, Kuskowski MA. 2002. The effects of milk protein concentrate on symptoms of osteoarthritis in adults: an exploratory, randomized, double-blind, placebo- controlled trial. Curr Ther Res 63: 430-442.
Wilkens P, Scheel IB, Grundnes O, Hellum C, Storheim K. 2010. Effect of glucosamine on pain-related disability in patients with chronic low back pain and degenerative lumbar osteoarthritis: a randomized controlled trial. JAMA 304: 45-52.
McAlindon T, Formica M, Valley ML, Lehmer M, Kabbara K. 2004. Effectiveness of glucosamine for symptoms of knee osteoarthritis: results from an internet-based randomized double-blind controlled trial. Am J Med 117: 643-649.
Cibere J, Kopec JA, Thorne A, Singer J, Canvin J, Ronvinson DB, Pope J, Hong P, Grant E, Esdaile JM. 2004. Randomized, double-blind, placebo-controlled glucosamine discontinuation trial in knee osteoarthritis. Arthritis Rheum 51: 738-745.
Hughes R, Carr A. 2002. A randomized, double-blind, placebo- controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee. Rheumatology 41: 279-284.
Rozendaal RM, Koes BW, Osch GJVM, Ultterlinden EJ, Garling EH, Willemsen SP, Ginai AZ, Verhaar JAN, Weinans H, Bierma-Zeinstra SMA. 2008. Effect of glucosamine sulfate on hip osteoarthritis: a randomized trial. Ann Intern Med 148: 268-277.
Rindone JP, Hiller D, Collacott E, Nordhaugen H, Arriola G. 2000. Randomized, controlled trial of glucosamine for treating osteoarthritis of the knee. West J Med 172: 91-94.
Trc T, Bohmova J. 2010. Efficacy and tolerance of enzymatic hydrolysed collagen (EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA). Int Orthop 35: 341-348.
Mehta K, Gala J, Bhasale S, Naik S, Modak M, Thakur H, Deo N, Miller MJS. 2007. Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial [ISRCTN25438351]. BMC Complement Altern Med 7: 34.
Wangroongsub Y, Tanavalee A, Wilairatana V, Ngarmukos S. 2010. Comparable clinical outcomes between glucosamine sulfate-potassium chloride and glucosamine sulfate sodium chloride in patients with mild and moderate knee osteoarthritis: a randomized, double-blind study. J Med Assoc Thai 93: 805-811.
Kawasaki T, Kurosawa H, Ikeda H, Kim S, Owasa A, Takazawa U, Mubota M, Ishijima M. 2008. Additive effects of glucosamine or risedronate for the treatment of osteoarthritis of the knee combined with home exercise: a prospective randomized 18-month trial. J Bone Miner Metab 26: 279-287.
Ng NT, Heesch KC, Brown WJ. 2010. Efficacy of a progressive walking program and glucosamine sulphate supplementation on osteoarthritic symptoms of the hip and knee: a feasibility trial. Arthritis Res Ther 12: R25.
Haflah NH, Jaarin K, Abdullah S, Omar M. 2009. Palm vitamin E and glucosamine sulphate in the treatment of osteoarthritis of the knee. Saudi Med J 30: 1432-1438.
Bennett AN, Crossley KM, Brucner PD, Hinman RS. 2007. Predictors of symptomatic response to glucosamine in knee osteoarthritis: an exploratory study. Br J Sports Med 41: 415-419.
Tao QW, Xu Y, Jin DE, Yan XP. 2009. Clinical efficacy and safety of Gubitong Recipe in treating osteoarthritis of knee joint. Chin J Integr Med 15: 458-461.
Yoshimura M, Sakamoto K, Tsuruta A, Yamamoto T, Ishida K, Yamaguchi H, Nagaoka I. 2009. Evaluation of the effect of glucosamine administration on biomarkers for cartilage and bone metabolism in soccer players. Int J Mol Med 24: 487-494.
Sawitzke AD, Shi H, Finco MF, Dunlop DD, Harris CL, Singer NG, Bradley JD, Silver D, Jackson CG, Lane NE, Oddis CV, Wolfe F, Lisse J, Furst DE, Bingham CO, Reda DJ, Moskowitz RW, Williams JH, Celgg DO. 2010. Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT. Ann Rheum Dis 69: 1459-1464.
Sawitzke AD, Shi H, Finco MF, Dunlop DD, Bingham CO, Harris CL, Singer NG, Bradley JD, Silver D, Jackson CG, Lane NE, Oddis CV, Wolfe F, Lisse J, Furst DE, Reda DJ, Moskowitz RW, Williams JH, Celgg DO. 2008. The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine/chondroitin arthritis intervention trial. Arthritis Rheum 58: 3183-3191.
Christgau S, Henrotin Y, Tanko LB, Rovati LC, Collette J, Bruyere O, Deroisy R, Reginster JY. 2004. Osteoarthritic patients with high cartilage turnover show increased responsiveness to the cartilage protecting effects of glucosamine sulphate. Clin Exp Rheumatol 22: 36-42.
Bruyere O, Honore A, Ethgen O, Rovatis LC, Giacovelli G, Henrotin YE, Seidel L, Reginster JYL. 2003. Correlation between radiographic severity of knee osteoarthritis and future disease progression. Results from a 3-year prospective, placebo-controlled study evaluating the effect of glucosamine sulfate. Osteoarthritis Cartilage 11: 1-5.
Bruyere O, Pavelka K, Rovati LC, Gatterova J, Giacovelli G, Olejarova M, Deroisy R, Reginster JY. 2008. Total joint replacement after glucosamine sulphate treatment in knee osteoarthritis: results of a mean 8-year observation of patients from two previous 3-year, randomised, placebo-controlled trials. Osteoarthritis Cartilage 16: 254-260.
Pavelka K, Bruyere O, Rovati LC, Olejarova M, Giacovelli G, Reginster JY. 2003. Relief in mild-to-moderate pain is not a confounder in joint space narrowing assessment of full extension knee radiographs in recent osteoarthritis structure- modifying drug trials. Osteoarthritis Cartilage 11:730-737.
Bruyere O, Pavelka K, Rovati LC, Deroisy R, Olejarova M, Gatterova J, Giacovelli G, Reginster JY. 2004. Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies. Menopause 11: 138-143.
Rovati LC, Pavelka K, Giacovelli G, Reginster JY. 2006. Assessment of joint space narrowing with conventional standing antero-posterior radiographs: relief in mild-to-moderate pain is not a confounder in recent osteoarthritis structure- modifying drug trials. Osteoarthritis Cartilage 14: A14-A18.
Cibere J, Thorne A, Kopec JA, Singer J, Canvin J, Robinson DB, Pope J, Hong P, Grant E, Lobanok T, Ionescu M, Poole AR, Esdaile JM. 2005. Glucosamine sulfate and cartilage type II collagen degradation in patients with knee osteoarthritis: randomized discontinuation trial results employing biomarkers. J Rheumatol 32: 896-902.
Rozendaal RM, Uitterlinden EJ, van Osch GJ, Garling EH, Willemsen SP, Ginai AZ, Verhaar JA, Weinans H, Koes BW, Bierma-Zeinstra SM. 2009. Effect of glucosamine sulphate on joint space narrowing, pain and function in patients with hip osteoarthritis; subgroup analyses of a randomized controlled trial. Osteoarthritis Cartilage 17: 427-432.
Petersson IF, Boegard T, Saxne T, Silman AJ, Svensson B. 1997. Radiographic osteoarthritis of the knee classified by the Ahlback and Kellgren & Lawrence systems for the tibiofemoral joint in people aged 35-54 years with chronic knee pain. Ann Rheum Dis 56: 493-496.
Henrotin H, Chevalier X, Herrero-Beaumont G, Mcalindon T, Mobasheri A, Pavelka K, Schon C, Weinans H, Biesalki H. 2013. Physiological effects of oral glucosamine on joint health: current status and consensus on future research priorities. BMC Rese Notes 6: 115.
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