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NTIS 바로가기Journal of applied biological chemistry, v.57 no.2, 2014년, pp.179 - 182
이도승 (Jeju Biodiversity Research Institute (JBRI), Jeju Technopark) , 부경환 (Subtropical Horticulture Research Institute, Jeju National University) , 김영천 (Subtropical Horticulture Research Institute, Jeju National University) , 이진만 (Department of Food & Biotechnology, Hoseo University) , 김성철 (Agricultural Research Center for Climate Change, National Institute of Horticultural & Herbal Science, Rural Development Administration) , 이왕식 (College of Applied Life Science(SARI), Jeju National University, Research Institute for Subtropical Agriculture and Biotechnology, Jeju National University) , 류기중 (College of Applied Life Science(SARI), Jeju National University, Research Institute for Subtropical Agriculture and Biotechnology, Jeju National University) , 이동선 (College of Applied Life Science(SARI), Jeju National University, Research Institute for Subtropical Agriculture and Biotechnology, Jeju National University)
In the present study, we investigated the effects of methanol extracts from Alpinia katsumadai Hayata against antiviral potential underlying mechanism in glucosidase inhibition. Syncytium formation in Newcastle disease virus (NDV)-infected baby hamster kidney (BHK) cell originates from the trafficki...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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HIV 감염된 세포에서의 합포체 형성은 어떻게 진행되는가? | Nojirimycin, N-butyldeoxynojirimycin, nectricine 및 castanospermine와 같은 α-glucosidase 저해제는 당단백질 수식의 초기단계를 저해함으로써 인간면역결핍 바이러스(HIV, human immunodeficiency virus)의 복제, 세포융합을 통한 syncytium (합포체) 형성의 저해활성을 나타낸다(Gruters 등, 1987; Johnson 등, 1989; Fischer 등, 1995; Tsujii 등, 1996; Dettenhofer와 Yu, 2001; Papandrou 등, 2002). HIV-1 envelope glycoprotein (Env)으로 알려진 outer membrane gp120와 transmembrane gp41 subunits은 precursor gp160의 절단으로부터 유래된다(Einfeld, 1996). Thelper cell 표면에 위치한 HIV 수용체인 gp41와 gp120은 lymphocytes 표면의 CD4 수용체에 결합하며, 이러한 상호작용을 통하여 거대하고 비기능적인 막융합을 야기시켜 syncytium(합포체)을 형성한다(Papandréou 등, 2002; Quinn, 2008). α-glucosidase inhibitor로써 Deoxynojirimycin와 그 유사체들은 (Papandrou 등, 2002) gp160으로부터 gp41와 gp120으로의 절단 활성을 감소시켜 정상적인 glycan processing을 저해함으로써 감염세포내에서 HIV 수용체의 형성을 방해한다. | |
glucosidase 저해에 민감한 바이러스는? | 그리고 α-glucosidase저해제는 당단백질 혹은 당지질의 수식을 통하여 항당뇨, 항암, 및 항바이러스 활성을 나타낸다(Dennis 등, 1987; Goss 등, 1995; Mehta 등, 1998; van de Laar 등 2005; Lee 등, 2007). 특히, 댕기바이러스, HIV, 간염바이러스 등을 포함한 해로운 바이러스들은 glucosidase 저해에 매우 민감한 것으로 알려졌다(Courageot 등, 2000). 이러한 이유로 인하여, α-glucosidase 저해제는 관련된 많은 질병의 치료제 개발 타켓으로써 뿐만 아니라 작용기작 연구에 이용된다(Courageot 등, 2000). | |
α-glucosidase 저해제에는 어떤 것들이 있는가? | Nojirimycin, N-butyldeoxynojirimycin, nectricine 및 castanospermine와 같은 α-glucosidase 저해제는 당단백질 수식의 초기단계를 저해함으로써 인간면역결핍 바이러스(HIV, human immunodeficiency virus)의 복제, 세포융합을 통한 syncytium (합포체) 형성의 저해활성을 나타낸다(Gruters 등, 1987; Johnson 등, 1989; Fischer 등, 1995; Tsujii 등, 1996; Dettenhofer와 Yu, 2001; Papandrou 등, 2002). HIV-1 envelope glycoprotein (Env)으로 알려진 outer membrane gp120와 transmembrane gp41 subunits은 precursor gp160의 절단으로부터 유래된다(Einfeld, 1996). |
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