[논문]Neuroprotective effects of Eriobotrya japonica and Salvia miltiorrhiza Bunge in in vitro and in vivo models

Bae, Donghyuck; Kim, Yongjae; Kim, Jihye; Kim, Yujin; Oh, Kyonyeo; Jun, Woojin; Kim, Sunoh

doi:10.1080/19768354.2014.903856

Neuroprotective effects of Eriobotrya japonica and Salvia miltiorrhiza Bunge in in vitro and in vivo models 원문보기

Animal cells and systems, v.18 no.2, 2014년, pp.119 - 134

Bae, Donghyuck (Jeollanamdo Institute of Natural Resources Research (JINR)) , Kim, Yongjae (Department of Food and Nutrition, Chonnam National University) , Kim, Jihye (Jeollanamdo Institute of Natural Resources Research (JINR)) , Kim, Yujin (Jeollanamdo Institute of Natural Resources Research (JINR)) , Oh, Kyonyeo (Jeollanamdo Institute of Natural Resources Research (JINR)) , Jun, Woojin (Department of Food and Nutrition, Chonnam National University) , Kim, Sunoh (Jeollanamdo Institute of Natural Resources Research (JINR))

Abstract ▼ AI-Helper

We previously reported that Eriobotrya japonica (EJ) improves the cognitive dysfunction caused by amyloid-${\beta}$ ($A{\beta}$) peptide injection. Here, we further examined the possible neuroprotective effects and the combined ameliorating effects of EJ and Salvia miltiorrhiza Bunge (SM) in various in vitro and in vivo models. We confirmed the combined effects of a mixture of 5% ethanol extract from EJ leaves (EJE) and water extract from SM roots (SMW) on $A{\beta}_{1-42}$-induced toxicity in an in vitro model. Treatment with the mixture (1:1) of EJ and SM (Mix) produced significantly better protection of cells from $A{\beta}$-induced toxicity and more strongly suppressed caspase-3 activity compared to treatment with EJE or SMW alone. Additionally, EJE, SMW, and Mix attenuated $CoCl_2$-induced hypoxic damage and corticosterone-induced impairment in SH-SY5Y cells. To examine the combined effects of EJE and SMW in in vivo models, behavioral performance in the Morris water maze was tested two days after injection of $A{\beta}_{1-42}$. Administration of Mix provided significantly more protection of spatial learning and memory against the impairments induced by $A{\beta}_{1-42}$ injection than did administration of EJE or SMW alone. Additionally, the behavioral deficits that accompanied $A{\beta}$-induced memory impairment were attenuated to a greater extent by the administration of the mixture. Furthermore, acetylcholinesterase (AChE) activity and neuronal apoptosis were significantly more inhibited in rats treated with $A{\beta}$ and the mixture than in rats treated with $A{\beta}_{1-42}$ alone. Thus, the results of this study indicate that the mixture of EJ and SM has combined effects that are neuroprotective against $A{\beta}_{1-42}$-induced neuronal toxicity.

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