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논문 상세정보

Abstract

This study investegated the effect of Liriope platyphylla (LP) on allergic reactions and its mechanism of action. We investigated the effect of LP on Evans Blue (EB) extravasation induced by anti-dinitrophenyl (DNP)-IgE in rats. We tested whether the ethanol extract of LP reduced ear skin thickness and historical changes induced by topical application of 2,4-dinitrofluorobenzene (DNFB) to ears of mice. We evaluated compound 48/80-induced release of histamine in rats peritoneal mast cell (RPMCs). We also investigated the regulatory effect of LP on the level of inflammatory mediators in PMACI-induced human mast cell (HMC-1); cytokine IL-6, IL-8, TNF-${\alpha}$ in HMC-1, MAPKs (ERK, JNK and p38) in HMC-1. The ethanol extract of LP (81.3 mg/100 g body weight) significantly inhibited the PCA reaction compared with the control (P < 0.05). However, LP did not prevent topical applications of DNFB-induced ear skin thickening and histological changes. In RPMCs, histamine release induced by compound 48/80 was significantly attenuated by LP at $100{\mu}g/ml$ (P < 0.05). LP extract ($100{\mu}g/ml$) significantly reduced the PMACI-induced IL-6, IL-8, and TNF-${\alpha}$ secretion via inhibition of ERK phosphorylation in HMC-1. In conclusion, the ethanol extract of LP inhibited mast cell-derived, immediate-type allergic reactions, and the result suggest the potential of LP for preventing allergic inflammatory disorders.

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참고문헌 (40)

  1. Roitt, I., Brostoff, J., Male, D. Immunology 6th eds, U.S.A., Mosby. pp 323-383, 2001. 
  2. Jeong K. Allergy and Oriental Medicine. Seoul, Jeil. p 15, 1993. 
  3. Lee, K., Kim, K.. Recent Treatment of Allergy. Seoul, Hankookeuihaksa. p 36, 2001. 
  4. Pyo, S., Son, E. Immunlology. Seoul, Shinil Books. pp 253-254, 1992. 
  5. Parham, P. Immunology. Seoul, Life Science. pp 351-352, 2011. 
  6. Kim, Y. Basic Pathology. Seoul, Hyunmoonsa. pp 138-140, 438-439, 2005. 
  7. Hack, C.E., Aarden, L.A., Thus, L.G. Role of cytokines in sepsis. Advances in Immunology 66:101-195, 1997. 
  8. Metz, M., Grimbaldeston, M.A., Nakae, S., Piliponsky, A.M., Tsai, M., Galli, S.J. Mast cells in the promotion and limitation of chronic inflammation. Immunological Reviews 217: 304-328, 2007. 
  9. Kim, S.H., Park, H.H., Lee, S., Jun, C.D., Choi, B.J., Kim, S.Y., Kim, S.H., Kim, D.K., Park, J.S., Chae, B.S., Shin, T.Y. The anti-anaphylactic effect of the gall of Rhus javanica is mediated through inhibition of histamine release and inflammatory cytokine secretion. International Immunopharmacology 5(13-14):1820-1829, 2005. 
  10. The Herbology Compilation Committee of College of Oriental Medicine. Herbology. Seoul, Youngrim. pp 645-646, 2004. 
  11. Jang, S. Bonchojoengeui. Seoul, Chunghong. 225, 2009. 
  12. Chu, J. Bonkyoungsozeng 1st. Daejeon, Joomin Publisher. p 167, 2012. 
  13. Lim, J. Herbal Pharmacognosy. Seoul, Shinil Books. p 390, 2012. 
  14. Jang, W. EuihakKyewon. Daejoen, Joomin Publisher. p 228, 2003. 
  15. Roh, S., Choi, H., Kim, D, Seo, Y. Studies of Anti-immflamation of Liriopis Tuber to Autoimmunune Diabetes in NOD mice. Korean Journal of Oriental Physiology & Pathology 22(4):766-770, 2008. 
  16. Park, S., Kim, Y. Effects of Liriopis Tuber on 4-HNE-induced Apoptosis in PC-12 Cells. Korean Journal of Herbology 28(2):33-38, 2013. 
  17. Lee, E., Yang, S., Kim, M., Nam, K., Park, Y. Effects of Root of Liriope Spicata on LPS-induced Lung Injury. Korean Journal of Oriental Physiology & Pathology 25(4):641-649, 2011. 
  18. Lee, Y.C., Lee, J.C., Seo, Y.B., Kook, Y.B. Liriopis tuber inhibit OVA-induced airway inflammation and bronchial hyperresponsiveness in murine model of asthma. Journal of Ethnopharmacology 101(1-3):144-152, 2005. 
  19. Kim, H.K., Lee, J.Y., Han, H.S., Kim, Y.J., Kim, H.J., Kim, Y.S., Kim, H.M., Ko, S.G., An, H.J., Lee, Y.J., Park, W. Immunomodulatory effects of Liriope platyphylla water extract on lipopolysaccharideactivated mouse macrophae. Nutrients 4(12):1887-1897, 2012. 
  20. Kang, Y., Lee, T.. Liriopis Tuber improves stress-induced memorial impairments in rats. Korean Journal of Herbology 28(2):33-38, 2013. 
  21. Kim, E.K., Kim, E.Y., Moon, P.D., Um, J.Y., Kim, H.M., Lee, H.S., Sohn, Y., Park, S.K., Jung, H.S., Sohn, N.W. Lithospermi Radix extract inhibits histamine release and production of inflammatory cytokine in mast cells. Bioscience Biotechnology Biochemistry 71(12):2886–2892, 2007. 
  22. Henz, B.M., Maurer, M., Lipper, U., Worm, M. and Babina, M.. Mast cells as initiators of immunity and host defense. Experimental Dermatology 10(1):1-10, 2001. 
  23. Huh, M.K., Huh, H.W., Choi, J.S., Lee, B.K. Genetic diversity and population structure of Liriope platyphylla (Liliaceae) in Korea. Journal of Life Science 17(3):328-333, 2007. 
  24. Church, M.K., Miller, P. Time courses of the anti-anaphylactic and anti-inflammatory effects of dexamethasone in the rat and mouse. British Journal of Pharmacology 62(4):481-486, 1978. 
  25. Inagaki, N., Nakamura, N., Nagao, M., Musoh, K., Kawasaki, H., Nagai, H. Participation of histamine H1 and H2 receptors in passive cutaneous anaphylaxis-induced scratching behavior in ICR mice. European Journal of Pharmacology 367(2-3):361-371, 1999. 
  26. Paton William, D.M.. Compound 48/80: a potent histamine liberator. British Journal of Pharmacology and Chemotherapy 6(3):499-508, 1951. 
  27. Katz, G., Cohen, S. Experimental evidence for histamine release in allergy. Journal of the American Medical Association 117(21):1782-1783, 1941. 
  28. Artuc, M., Hermes, B., Steckelings, U.M., Grutzkau, A., Henz, B.M. Mast cells and their mediators in cutaneous wound healing-active participants or innocent by standers? Experimental Dermatology 8(1):1-16, 1999. 
  29. Chang, L., Kamata, H., Solinas, G., Luo, J.L., Maeda, S., Venuprasad, K., Liu, Y.C., Karin, M. The E3 ubiquitin ligase itch couples JNK activation to TNF alpha induced cell death by inducing c-FLIP(L) turnover. Cell 124(3):601-613, 2006. 
  30. Dinarello, C.A., Bernheim, H.A., Duff, G.W., Le, H.V., Nagabhushan, T.L., Hamilton N.C., Coceani F.. Mechanisms of fever induced by recombinant human interferon. Journal of Clinical Investigation 74(3):906-913, 1984. 
  31. Erzen, B., Sabovic, M., Sebestjen, M., Keber, I., Poredos, P. Interleukin-6 correlates with endothelial dysfunction in young post-myocardial infarction patients. Cardiology 107(2):111-116, 2006. 
  32. Sehgal, P.B., Greininger, G., Tosato, G. Regulation of the acute phase and immune responses: interleukin-6. The New York Academy of Sciences 557: 1-583, 1989. 
  33. Gabay, C., Kushne, I.. Acute-phase proteins and other systemic responses to inflammation. New England Journal of Medicine 340(6):448-454, 1999. 
  34. Santhanam, U., Avila, C., Romero, R., Viguet, H., Ida, N., Sakurai, S., Sehgal, P.B. Cytokines in normal and abnormal parturition: elevated amniotic fluid interleukin-6 levels in women with premature rupture of membranes associated with intrauterine infection. Cytokine 3(2):155-163, 1991. 
  35. Koch, A.E., Polverini, P.J., Kunkel, S.L., Harlow, L.A., Dipietro, L.A., Elner, V.M., Elner, S.G., Strieter, R.M. Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 258(5089):1798-1801, 1992. 
  36. Salcedo, R., Ponce, M.L., Young, H.A., Wasserman, K., Ward, J.M., Kleinman, H., Oppenheim, J.J., Murphy, W.J. Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression. Blood 96(1):34-40, 2000. 
  37. Goldsby, R.A., Kindt, T.J., Osborne, B.A., Kuby, J. Leukocyte migration and inflammation. Immunology 5th ed. New York, WH Freeman and Company. pp 338-360, 2003. 
  38. Leppa, S., Saffrich, R., Ansorge, W., Bohmann, D. Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation. The EMBO Journal 17(15):4404-4413, 1998. 
  39. Puddicombe, S.M., Davies, D.E. The role of MAP kinases in intracellular signal transduction in bronchial epithelium. Clinical and Experimental Allergy 30(1):7-11, 2000. 
  40. Guise, S., Braguer, D., Carles, G., Delacourte, A., Briand, C. Hyperphosphorylation of tau is mediated by ERK activation during anticancer drug-induced apoptosis in neuroblastoma cells. Journal of Neuroscience Research 63(3):257-267, 2001. 

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