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NTIS 바로가기한국식품위생안전성학회지 = Journal of food hygiene and safety, v.30 no.1, 2015년, pp.98 - 102
최경희 (원광대학교 치의예과) , 김세정 (숙명여자대학교 식품영양학과) , 윤요한 (숙명여자대학교 식품영양학과)
Oleanolic acid and its derivatives are pentacyclic triterpene acids, which are produced in many plants and herbs. These are considered safe and thus, oleanolic acid is now used for cosmetic and pharmaceutical industry. Oleanolic acid affects peptidoglycan in cell wall of bacteria. Hence, the antimic...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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Oleanolic acid가 생장을 억제하는 병원성 세균의 종류는? | Oleanolic acid의 항균활성에 대한 초기의 연구결과는 주로 식중독 세균보다는 일반 병원성 세균에 대한 연구가 주를 이루고 있다. 특히 Streptococcus pneumoniae, Streptococcus mutans, Mycobacterium tuberculosis 등과 같은 병원성 세균의 생장을 억제한다는 연구결과들이 있으며, methicillin-resistant Staphylcoccus aureus (MRSA)나 vancomycin-resistant enterococci (VRE)등과 같은 항생제 내성 세균의 생장을 저해하는 것으로 밝혀졌다1,31-33). | |
Oleanolic acid이 자연계에 존재하는 형태는? | Oleanolic acid는 pentacyclic triterpene으로 유리산이나 triterpenoid saponin의 아글리콘 형태로 자연계에 흔히 존재하면서3), 항산화11,12), 염증반응 억제13), 간 보호14), 위 보호15), 암세포에 대한 독성16), 항 궤양17), 항고지혈증18) 등에 대한 생리활성을 가지고 있다19-21). 따라서 식중독 세균을 제어하기 위해 oleanolic acid를 식품에 적용하면 다양한 생리활성 효능이 있을 수 있다. | |
oleanolic acid의 항균활성이 균주별로 달리 나타나는 이유는? | coli의 생장을 일정기간 저해하였다34). 이러한 상반되는 결과는 oleanolic acid에 대한 E. coli 균주별 저항성의 차이 때문인 것으로 사료된다. Fontanay 등은 이러한 oleanolic acid에 대한 균주별 항균활성 효능의 차이를 측정하기 위해 두 종류의 S. |
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