[논문]복분자딸기(Rubus coreanus Miquel)의 항암 및 항염 효과

송유나; 이헌옥; 노건민; 최정숙; 김행란; 엄애선

doi:10.20878/cshr.2015.21.5.015

복분자딸기(Rubus coreanus Miquel)의 항암 및 항염 효과
Review on Anti-Cancer and Anti-Imflammatory Activity from Rubus coreanus Miquel 원문보기

Culinary science & hospitality research = 한국조리학회지, v.21 no.5 = no.74, 2015년, pp.160 - 170

송유나 (한양대학교 생활과학대학 식품영양학과) , 이헌옥 (한양대학교 생활과학대학 식품영양학과) , 노건민 (농촌진흥청 국립농업과학원 기능성식품과) , 최정숙 (농촌진흥청 국립농업과학원 기능성식품과) , 김행란 (농촌진흥청 국립농업과학원 기능성식품과) , 엄애선 (한양대학교 생활과학대학 식품영양학과)

초록
AI-Helper

최근 암에 의한 사망률이 증가하고, 암 치료를 위한 화학적 항암제의 부작용이 지속적으로 대두됨에 따라 암 예방뿐 아니라, 항암제의 부작용을 감소시키면서 효과는 유지시킬 수 있는 방법이 필요하다. 이를 위해 최근 천연물과 항암제의 병용투여법이 주목 받고 있으며, 보다 안전하고 효과적인 천연물질의 개발이 요구된다. 최근 복분자딸기의 항산화, 항암, 항염 등 다양한 생리활성이 부각되면서 소비가 지속적으로 증가하고 있다. 또한 이러한 생리활성을 활용하여 식품, 주류, 화장품과 의약품과 같은 분야에서 복분자딸기를 이용한 다양한 상품이 개발되고 있다. 따라서 이 고찰은 복분자딸기의 항암 및 항염증 효능에 대한 연구결과와 복분자딸기의 특허동향을 정리하였다. 향후 복분자 딸기의 열매뿐 아니라, 줄기, 잎 등 다양한 부위를 활용한 천연유래 기능성 소재 개발 및 복분자딸기의 다양한 응용가능성을 모색하기 위한 더 많은 연구가 이루어져야 할 것으로 여겨진다.

Abstract ▼ AI-Helper

In accordance to the increasing number of death due to cancer and side effects of chemotherapy, attention has recently focused on combined treatment of natural component and anti-tumor agent. Therefore development of safe and effective functional substances derived from natural materials is required. The emergence of various functional activities of Rubus coreanus Miquel, such as antioxidant, anticancer, anti-inflammatory, etc. is continuously increasing its consumption. To utilize the above activities, many products developed by using Rubus coreanus Miquel extracts in the areas of foods, liquors, and cosmetics and medicines. In this review, anti-cancer, anti-inflammatory activity and patents of Rubus coreanus Miquel are summarized. Further studies are needed to search for development of functional material from natural origin and various application possibility using stem, leaf and fruit of Rubus coreanus Miquel.

주제어

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문제 정의

This study organized the research results of R. coreanus’s medicinal properties, especially its anticancer and anti-inflammation function.

성능/효과

1. R. coreanus extracts displayed anti-cancer effects mostly through cancer cell growth inhibition, DNA damage induction, and cancer cell death process. And unripe fruit extract was shown to be much more effective than fully ripe fruit extract.
2. R. coreanus extract displayed anti-inflammatory effects by decreasing expression of inflammation related genes and inflammation mediated substances in inflammatory response induced macrophage. The ripened level of R.
According to this data, unripe and fully ripe R. coreanus fruit intake not only suppresses inflammatory response related gene expression, but also suppresses occurrence of chronic illnesses, especially cardiovascular related gene, ceruloplasmin, vascular endothelial growth factor(VEGF) A, tissue plasminogen activation(tPA), thrombospondin 1. It revealed effective in preventing thrombosis or various cardiovascular related illnesses.
All the mice were fed unripe or fully ripe fruits and their prostate tumor size significantly decrease in both groups compared to those not fed R. coreanus(p<0.05).
coreanus and ethanol extracts of unripe fruit (EUR) suppresses the growth of androgen-dependent LNCaP cell and androgen-independent DU145 cell. As the result of EUR administration, the expression of the proliferating tumor cell markers and cancer gene like proliferating cell nuclear antigen (PCNA) and cyclin D1 and CDK4, decreased. Its effects were greater in LNCaP, an androgen-dependent prostate cancer cell compared to androgen-independent DU145 cell.
In HeLa cells, of 100, 200, 400, 600, 700 μg/assay R. coreanus extract concentration, 700 μg/assay concentration showed high growth suppression with over 65% (ethanol extracts of Rubus coreanus, ERC 68.5%, hot water extract, HWE 66.4%) and Hep3B also showed high growth suppression with 67.2% and 65.8% in ERC and HWE, respectively.
It was observed that R. coreanus extracts not only induced decrease of breast cancer cell’s activity and membrane permeability but also induced cell death by controlling gene expression contributing to cell death.
The result showed unripe and fully ripe R. coreanus intake significantly suppressed TNF-α production(p<0.05) but IL-1β and IL-6 only decreased with unripe R. coreanus and PGE2 secretion was not affected by either unripe or fully ripe R. coreanus.
coreanus on tumor cell growth suppression. The result was R. coreanus showed greater cancer cell suppression effect than dong qual(Korean angelica root). Furthermore, when water extract of R.
) administered in human origin stomach cancer cells, AGS and Kato3 cells, to investigate growth hindrance and DNA damage. The results showed R. coreanus suppressed growth activity in AGS and Kato3 cells and induced high DNA damage effects. When 100 μg/mL of buthanol fr, ethyl acetate fr.

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