[논문]일부 동물성 한약재의 독성과 안전성등급화 - 봉독, 사독, 반묘와 오공을 중심으로 -

박영철; 이선동

일부 동물성 한약재의 독성과 안전성등급화 - 봉독, 사독, 반묘와 오공을 중심으로 -
Toxicity and safety classification of 4 animal medicines - Focusing on venoms from bee, snake, blister beetle and scolopendrid - 원문보기

대한예방한의학회지 = Journal of Society of Preventive Korean Medicine, v.20 no.1, 2016년, pp.125 - 144

박영철 (대구가톨릭대학교 GLP센터) , 이선동 (상지대학교 한의과대학 예방의학교실)

Abstract ▼ AI-Helper

Objectives : About 13% of the medicines used by traditional korean medicines(TKM), are called animal medicines and are derived from non-herbal sources such as animals and insects. However, the clinical use of these preparations from animal medicines is often based on tradition and belief, rather than on evidence of toxicity and efficacy. As a result, animal medicines containing toxin have caused serious problems from injecting patients with venom. Here, various venoms frequently used as TKM were reviewed in terms of their instinct toxity and tried to estimate their safety classification. Methods : The estimation of safety classification was based on human equivalent dose(HED)-based MOS (margin of safety) and clinical dose applied for patients. Results and Conclusions : Except that of snake venom due to no clinical dose, they were evaluated as class 3 for bee venom, class 4 for cantharidin, toxin from blister beetle, and class 1 for venom from scolopendrid. In conclusion, animal medicines showed a wide range of safety classification from class 1 to class 4. This wide range is estimated to result from extremely limited applications of each venom for patients because of their strong toxicity. However, it should be cautious for application in clinics since animal medicines can produce anaphylactic reactions particularly after veinous administration even with a tiny amount of venom.

주제어

질의응답

핵심어	질문	논문에서 추출한 답변
	봉침요 법은 무엇인가?	최근에는 약침요법을 바탕으로 봉 독요법(또는 봉침요법, Apitherapy, Bee venom therapy)이 개발되어 임상에 응용되고 있다8). 봉침요 법이란 꿀벌(Apis mellifera)의 침으로 인체의 경혈을 자극하고 침액을 인체 내에 주입하여 각종 질병을 치료 하는 것을 말한다. 봉침요법에는 꿀벌의 침을 직접 피 부 표면에 찌르는 발침자법 및 직잡법과 더불어 주사 요법, 이온 전기도입법, 초음파요법, 연고 등을 통해 봉독이 치료에 응용되고 있다9),10).
	1차대사산물은 무엇인가?	한약은 식물성, 동물성 그리고 광물성으로 크게 구분 되지만 일반적으로 사람에게 사용되는 한약은 대부분 식물성 한약이다. 생체를 구성하는 4대 거대분자인 당, 단백질과 핵산을 비롯하여 지질을 1차대사산물이라고 한다. 반면에 식물에서 1 차대사산물로부터 새롭게 합 성되어 생리적 기능을 수행하는 물질을 2차대사산물 또는 식물성천연화학물질(phytochemicals)이라고 한다1).
	식물성천연화학 물질은 의약품, 항생제 등의 개발을 위해 광범위하게 이루어져 왔고 특히 오랜 기간을 걸쳐 이용된 한방 처방에 있어서 약효의 기본적 근원이되는 이유는?	반면에 식물에서 1 차대사산물로부터 새롭게 합 성되어 생리적 기능을 수행하는 물질을 2차대사산물 또는 식물성천연화학물질(phytochemicals)이라고 한다1). 대부분의 식물성천연화학물질은 식물이 자외선과 외부 환경에 대항하여 자신을 보호하려는 목적에서 생 성하는 물질이다. 이러한 특성 때문에 식물성천연화학 물질은 의약품, 항생제 등의 개발을 위해 광범위하게 이루어져 왔고 특히 오랜 기간을 걸쳐 이용된 한방 처방에 있어서 약효의 기본적 근원이 된다.

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저자의 다른 논문 :

표제어: PCR

동의어: Packet Collision Rate

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용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

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