Objectives This study investigated associations between symptom severity and neurocognitive functions in patients with major depressive disorder using comprehensive neuropsychological tests. Methods Ten patients with low depression (LD) and 22 patients with high depression (HD) participated. Symptom severity was determined by both the Beck Depression Inventory and the Hamilton Depression Rating Scale. Additionally, anxiety was measured by the Korean version of the State-Trait Anxiety Inventory (STAI-KYZ). Ten subtests of the Korean-Wechsler Adult Intelligence scale (K-WAIS), Stroop test, the word/design fluency tests were administered to assess cognition. Results The LD and HD groups did not differ in any of cognitive measures but anxiety level. Namely, the HD group obtained significantly higher scores on the state (U = 29.50, p < 0.01) and trait (U = 28.50, p < 0.001) anxiety scales than the LD group. A significant interaction effect between trait anxiety and depression severity was observed on the picture arrangement subtest of the K-WAIS [F (1, 27) = 5.09, p < 0.05]. Conclusions Cognitive deficits observed in patients with major depressive disorder may be related to other factors rather than current symptom severity. Trait anxiety possibly moderates the effect of current symptom severity on social judgment in these patients.
주요 우울 삽화는 뇌에 신경독성(neurotoxicity)으로 작용하는 일종의 외상 사건(traumatic event)이므로 우울 삽화의 경험은 인지기능 저하를 수반할 수 있으며, 삽화가 반복될수록 인지기능 저하가 더 심각할 수 있다. 1) 2) 인지기능의 결함이 개인의 일상생활에서의 기능 및 삶의 질에 부정적 영향을 미치기 때문에 환자가 가지는 인지기능의 결함을 정확하게 이해하는 것은 중요하다.
주요 우울 삽화는 뇌에 신경독성(neurotoxicity)으로 작용하는 일종의 외상 사건(traumatic event)이므로 우울 삽화의 경험은 인지기능 저하를 수반할 수 있으며, 삽화가 반복될수록 인지기능 저하가 더 심각할 수 있다. 1) 2) 인지기능의 결함이 개인의 일상생활에서의 기능 및 삶의 질에 부정적 영향을 미치기 때문에 환자가 가지는 인지기능의 결함을 정확하게 이해하는 것은 중요하다. 3) 주요우울장애(major depressive dis-order, 이하 MDD) 환자의 인지기능을 조사한 선행 연구들은 MDD 환자들이 인지기능의 결함, 특히 기억, 주의력, 집행 기능 및 정신운동속도의 결함을 가지고 있음을 비교적 일관 되게 보고하였다.
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