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Validation of Neurotensin Receptor 1 as a Therapeutic Target for Gastric Cancer

Molecules and cells, v.41 no.6, 2018년, pp.591 - 602  

Akter, Hafeza (Molecular Recognition Research Center, Korea Institute of Science and Technology) ,  Yoon, Jung Hwan (Department of Pathology, College of Medicine, The Catholic University of Korea) ,  Yoo, Young Sook (Molecular Recognition Research Center, Korea Institute of Science and Technology) ,  Kang, Min-Jung (Molecular Recognition Research Center, Korea Institute of Science and Technology)

Abstract AI-Helper 아이콘AI-Helper

Gastric cancer is the fifth most common type of malignancy worldwide, and the survival rate of patients with advanced-stage gastric cancer is low, even after receiving chemotherapy. Here, we validated neurotensin receptor 1 (NTSR1) as a potential therapeutic target in gastric cancer. We compared NTS...

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문제 정의

  • , 2015). Therefore, in this study, we confirmed the effects of NT on gastric cancer-tissue samples. The role of NTSR1 on metastasis in different gastric cancer cells and compared these results to the effects of similar treatment of other cancer-cell lines to determine whether NTSR1, could serve as new gastric cancer-specific therapeutic targets.

가설 설정

  • , 2015). In this study, we tested the hypothesis that NTSR1 plays important roles in gastric cancer progression and could serve as new specific and effective therapeutic target. Here, we validated NTSR1 as a therapeutic target in gastric cancer by measuring NTSR1 mRNA levels in gastric cancer cells and human tissue samples.
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